Basophil FcεRI Expression in Chronic Spontaneous Urticaria: A Potential Immunological Predictor of Response to Omalizumab Therapy
Although the efficacy of omalizumab has been clearly demonstrated in the treatment of chronic spontaneous urticaria (CSU), its mechanism of action, which results in improvement in CSU symptoms, is not entirely understood. This study investigated the effect of omalizumab on expression of...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Medical Journals Sweden
2017-03-01
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| Series: | Acta Dermato-Venereologica |
| Subjects: | |
| Online Access: |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2654
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| Summary: | Although the efficacy of omalizumab has been clearly demonstrated in the
treatment of chronic spontaneous urticaria (CSU), its mechanism of
action, which results in improvement in CSU symptoms, is not entirely
understood. This study investigated the effect of omalizumab on
expression of the high-affinity IgE receptor (FcεRI) on blood
basophils from patients with active CSU, and its association with the
clinical response. Patients exhibiting significant clinical
improvement showed a sharp reduction in the levels of basophil FcεRI
after 4 weeks, which was maintained throughout the total duration of
the treatment. Such evolution was not observed in non-responder
patients. Furthermore, non-responders showed significantly lower
baseline levels of FcεRI than responders. Baseline basophil FcεRI
expression was found to be a potential immunological predictor of
response to omalizumab (100% sensitivity and 73.2% specificity). The
results of this study contribute to our knowledge of the therapeutic
benefit and mechanism of action of anti-IgE therapy in CSU. |
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| ISSN: | 0001-5555 1651-2057 |