Basophil FcεRI Expression in Chronic Spontaneous Urticaria: A Potential Immunological Predictor of Response to Omalizumab Therapy
Although the efficacy of omalizumab has been clearly demonstrated in the treatment of chronic spontaneous urticaria (CSU), its mechanism of action, which results in improvement in CSU symptoms, is not entirely understood. This study investigated the effect of omalizumab on expression of...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Medical Journals Sweden
2017-03-01
|
| Series: | Acta Dermato-Venereologica |
| Subjects: | |
| Online Access: |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2654
|
| _version_ | 1819002907410825216 |
|---|---|
| author | Gustavo Deza Marta Bertolín-Colilla Ramon M. Pujol Laia Curto-Barredo Dulce Soto Maribel García Pilar Hernández Ramon Gimeno Ana M. Giménez-Arnau |
| author_facet | Gustavo Deza Marta Bertolín-Colilla Ramon M. Pujol Laia Curto-Barredo Dulce Soto Maribel García Pilar Hernández Ramon Gimeno Ana M. Giménez-Arnau |
| author_sort | Gustavo Deza |
| collection | DOAJ |
| description | Although the efficacy of omalizumab has been clearly demonstrated in the
treatment of chronic spontaneous urticaria (CSU), its mechanism of
action, which results in improvement in CSU symptoms, is not entirely
understood. This study investigated the effect of omalizumab on
expression of the high-affinity IgE receptor (FcεRI) on blood
basophils from patients with active CSU, and its association with the
clinical response. Patients exhibiting significant clinical
improvement showed a sharp reduction in the levels of basophil FcεRI
after 4 weeks, which was maintained throughout the total duration of
the treatment. Such evolution was not observed in non-responder
patients. Furthermore, non-responders showed significantly lower
baseline levels of FcεRI than responders. Baseline basophil FcεRI
expression was found to be a potential immunological predictor of
response to omalizumab (100% sensitivity and 73.2% specificity). The
results of this study contribute to our knowledge of the therapeutic
benefit and mechanism of action of anti-IgE therapy in CSU. |
| first_indexed | 2024-12-20T23:12:34Z |
| format | Article |
| id | doaj.art-7cafcf4b3add440e9ecadaceef0da76d |
| institution | Directory Open Access Journal |
| issn | 0001-5555 1651-2057 |
| language | English |
| last_indexed | 2024-12-20T23:12:34Z |
| publishDate | 2017-03-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj.art-7cafcf4b3add440e9ecadaceef0da76d2022-12-21T19:23:42ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572017-03-0197669870410.2340/00015555-26544934Basophil FcεRI Expression in Chronic Spontaneous Urticaria: A Potential Immunological Predictor of Response to Omalizumab TherapyGustavo Deza0Marta Bertolín-ColillaRamon M. PujolLaia Curto-BarredoDulce SotoMaribel GarcíaPilar HernándezRamon GimenoAna M. Giménez-Arnau Department of Dermatology, Hospital del Mar-Institut Mar d'Investigacions Mèdiques, Universitat Autònoma de Barcelona (UAB), Passeig Marítim, 25-29, ES-08003 Barcelona, Spain. gustavo.deza@gmail.com. Although the efficacy of omalizumab has been clearly demonstrated in the treatment of chronic spontaneous urticaria (CSU), its mechanism of action, which results in improvement in CSU symptoms, is not entirely understood. This study investigated the effect of omalizumab on expression of the high-affinity IgE receptor (FcεRI) on blood basophils from patients with active CSU, and its association with the clinical response. Patients exhibiting significant clinical improvement showed a sharp reduction in the levels of basophil FcεRI after 4 weeks, which was maintained throughout the total duration of the treatment. Such evolution was not observed in non-responder patients. Furthermore, non-responders showed significantly lower baseline levels of FcεRI than responders. Baseline basophil FcεRI expression was found to be a potential immunological predictor of response to omalizumab (100% sensitivity and 73.2% specificity). The results of this study contribute to our knowledge of the therapeutic benefit and mechanism of action of anti-IgE therapy in CSU. https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2654 basophilsdown-regulationFcεRIIgEreceptoromalizumab |
| spellingShingle | Gustavo Deza Marta Bertolín-Colilla Ramon M. Pujol Laia Curto-Barredo Dulce Soto Maribel García Pilar Hernández Ramon Gimeno Ana M. Giménez-Arnau Basophil FcεRI Expression in Chronic Spontaneous Urticaria: A Potential Immunological Predictor of Response to Omalizumab Therapy Acta Dermato-Venereologica basophils down-regulation Fcε RI IgEreceptor omalizumab |
| title | Basophil FcεRI Expression in Chronic Spontaneous
Urticaria: A Potential Immunological Predictor of Response to
Omalizumab Therapy |
| title_full | Basophil FcεRI Expression in Chronic Spontaneous
Urticaria: A Potential Immunological Predictor of Response to
Omalizumab Therapy |
| title_fullStr | Basophil FcεRI Expression in Chronic Spontaneous
Urticaria: A Potential Immunological Predictor of Response to
Omalizumab Therapy |
| title_full_unstemmed | Basophil FcεRI Expression in Chronic Spontaneous
Urticaria: A Potential Immunological Predictor of Response to
Omalizumab Therapy |
| title_short | Basophil FcεRI Expression in Chronic Spontaneous
Urticaria: A Potential Immunological Predictor of Response to
Omalizumab Therapy |
| title_sort | basophil fcεri expression in chronic spontaneous urticaria a potential immunological predictor of response to omalizumab therapy |
| topic | basophils down-regulation Fcε RI IgEreceptor omalizumab |
| url |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2654
|
| work_keys_str_mv | AT gustavodeza basophilfceriexpressioninchronicspontaneousurticariaapotentialimmunologicalpredictorofresponsetoomalizumabtherapy AT martabertolincolilla basophilfceriexpressioninchronicspontaneousurticariaapotentialimmunologicalpredictorofresponsetoomalizumabtherapy AT ramonmpujol basophilfceriexpressioninchronicspontaneousurticariaapotentialimmunologicalpredictorofresponsetoomalizumabtherapy AT laiacurtobarredo basophilfceriexpressioninchronicspontaneousurticariaapotentialimmunologicalpredictorofresponsetoomalizumabtherapy AT dulcesoto basophilfceriexpressioninchronicspontaneousurticariaapotentialimmunologicalpredictorofresponsetoomalizumabtherapy AT maribelgarcia basophilfceriexpressioninchronicspontaneousurticariaapotentialimmunologicalpredictorofresponsetoomalizumabtherapy AT pilarhernandez basophilfceriexpressioninchronicspontaneousurticariaapotentialimmunologicalpredictorofresponsetoomalizumabtherapy AT ramongimeno basophilfceriexpressioninchronicspontaneousurticariaapotentialimmunologicalpredictorofresponsetoomalizumabtherapy AT anamgimenezarnau basophilfceriexpressioninchronicspontaneousurticariaapotentialimmunologicalpredictorofresponsetoomalizumabtherapy |