The influenza hemagglutinin stem antibody CR9114: Evidence for a narrow evolutionary path towards universal protection

The influenza hemagglutinin stem antibody CR9114: Evidence for a narrow evolutionary path towards universal protection

Human monoclonal antibodies (hmAbs) that protect against all influenza A and B strains are considered the road to universal influenza vaccines. Based on publicly-available data, we analyze the mechanistic and structural basis of pan-influenza protection by CR9114, a hemagglutinin (HA) stem-reactive...

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Bibliographic Details
Main Authors: Anna L. Beukenhorst, Jacopo Frallicciardi, Clarissa M. Koch, Jaco M. Klap, Angela Phillips, Michael M. Desai, Kanin Wichapong, Gerry A. F. Nicolaes, Wouter Koudstaal, Galit Alter, Jaap Goudsmit
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Virology
Subjects:
broadly neutralizing antibodies
influenza virus
pan-influenza protection
CR9114
correlate of protection
antiviral therapies
Online Access:https://www.frontiersin.org/articles/10.3389/fviro.2022.1049134/full

Internet

https://www.frontiersin.org/articles/10.3389/fviro.2022.1049134/full

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