Cigarette smoke extract enhances neutrophil elastase-induced IL-8 production via proteinase-activated receptor-2 upregulation in human bronchial epithelial cells
Lung disease: How cigarette smoking enhances lung inflammation A study of the effect of cigarette smoke extract (CSE) on lung lining cells clarifies the interaction between CSE and an enzyme implicated in causing chronic obstructive pulmonary disease (COPD). The enzyme elastase is released by neutro...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-07-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-018-0114-1 |
| _version_ | 1818730666960879616 |
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| author | Kyoung-Hee Lee Jinwoo Lee Jiyeong Jeong Jisu Woo Chang-Hoon Lee Chul-Gyu Yoo |
| author_facet | Kyoung-Hee Lee Jinwoo Lee Jiyeong Jeong Jisu Woo Chang-Hoon Lee Chul-Gyu Yoo |
| author_sort | Kyoung-Hee Lee |
| collection | DOAJ |
| description | Lung disease: How cigarette smoking enhances lung inflammation A study of the effect of cigarette smoke extract (CSE) on lung lining cells clarifies the interaction between CSE and an enzyme implicated in causing chronic obstructive pulmonary disease (COPD). The enzyme elastase is released by neutrophils and is known to induce inflammation, which causes lung irritation in COPD. Chul-Gyu Yoo and colleagues at Seoul National University in South Korea exposed cultured human lung cells to CSE. This exposure activated specific molecular signaling processes by which the elastase enzyme-induced inflammation was enhanced. Of particular note was an increase in the levels of a cell surface receptor protein in CSE-treated cells. This protein was increased in lungs of smokers and COPD patients. The research helps to understand the role of cigarette smoking in the pathogenesis of COPD. |
| first_indexed | 2024-12-17T23:05:25Z |
| format | Article |
| id | doaj.art-7cb17fe0ed5d48ecb4c3d44625a030e2 |
| institution | Directory Open Access Journal |
| issn | 1226-3613 2092-6413 |
| language | English |
| last_indexed | 2024-12-17T23:05:25Z |
| publishDate | 2018-07-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-7cb17fe0ed5d48ecb4c3d44625a030e22022-12-21T21:29:17ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132018-07-015071910.1038/s12276-018-0114-1Cigarette smoke extract enhances neutrophil elastase-induced IL-8 production via proteinase-activated receptor-2 upregulation in human bronchial epithelial cellsKyoung-Hee Lee0Jinwoo Lee1Jiyeong Jeong2Jisu Woo3Chang-Hoon Lee4Chul-Gyu Yoo5Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University HospitalDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University HospitalDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University HospitalDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University HospitalDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University HospitalDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University HospitalLung disease: How cigarette smoking enhances lung inflammation A study of the effect of cigarette smoke extract (CSE) on lung lining cells clarifies the interaction between CSE and an enzyme implicated in causing chronic obstructive pulmonary disease (COPD). The enzyme elastase is released by neutrophils and is known to induce inflammation, which causes lung irritation in COPD. Chul-Gyu Yoo and colleagues at Seoul National University in South Korea exposed cultured human lung cells to CSE. This exposure activated specific molecular signaling processes by which the elastase enzyme-induced inflammation was enhanced. Of particular note was an increase in the levels of a cell surface receptor protein in CSE-treated cells. This protein was increased in lungs of smokers and COPD patients. The research helps to understand the role of cigarette smoking in the pathogenesis of COPD.https://doi.org/10.1038/s12276-018-0114-1 |
| spellingShingle | Kyoung-Hee Lee Jinwoo Lee Jiyeong Jeong Jisu Woo Chang-Hoon Lee Chul-Gyu Yoo Cigarette smoke extract enhances neutrophil elastase-induced IL-8 production via proteinase-activated receptor-2 upregulation in human bronchial epithelial cells Experimental and Molecular Medicine |
| title | Cigarette smoke extract enhances neutrophil elastase-induced IL-8 production via proteinase-activated receptor-2 upregulation in human bronchial epithelial cells |
| title_full | Cigarette smoke extract enhances neutrophil elastase-induced IL-8 production via proteinase-activated receptor-2 upregulation in human bronchial epithelial cells |
| title_fullStr | Cigarette smoke extract enhances neutrophil elastase-induced IL-8 production via proteinase-activated receptor-2 upregulation in human bronchial epithelial cells |
| title_full_unstemmed | Cigarette smoke extract enhances neutrophil elastase-induced IL-8 production via proteinase-activated receptor-2 upregulation in human bronchial epithelial cells |
| title_short | Cigarette smoke extract enhances neutrophil elastase-induced IL-8 production via proteinase-activated receptor-2 upregulation in human bronchial epithelial cells |
| title_sort | cigarette smoke extract enhances neutrophil elastase induced il 8 production via proteinase activated receptor 2 upregulation in human bronchial epithelial cells |
| url | https://doi.org/10.1038/s12276-018-0114-1 |
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