Effect of Photobiomodulation With Different Wavelengths on Radiodermatitis Treatment
Background:. Approximately 80% of patients submitted to radiotherapy develop radiodermatitis. Photobiomodulation based on light-emitted diode (LED) is one of the therapeutic strategies for treating inflammation. This study aimed to investigate the effect of the photobiomodulation with two wavelength...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2023-02-01
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| Series: | Plastic and Reconstructive Surgery, Global Open |
| Online Access: | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000004809 |
| _version_ | 1797894198179921920 |
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| author | Cristina Pires Camargo, MD, PhD Arturo Forner-Cordero, PhD Bruna Matsumoto Silva, BEng Vinícius Melo de Souza, BEng Higor Souza Cunha, BEng Yasmin de Oliveira Feitosa, BEng Guilherme Arellano Campello, BEng Pedro Henrique Gianjoppe dos Santos, BEng Carolina Logo Rego, BEng Heloisa Carvalho, MD, PhD Rolf Gemperli, MD, PhD |
| author_facet | Cristina Pires Camargo, MD, PhD Arturo Forner-Cordero, PhD Bruna Matsumoto Silva, BEng Vinícius Melo de Souza, BEng Higor Souza Cunha, BEng Yasmin de Oliveira Feitosa, BEng Guilherme Arellano Campello, BEng Pedro Henrique Gianjoppe dos Santos, BEng Carolina Logo Rego, BEng Heloisa Carvalho, MD, PhD Rolf Gemperli, MD, PhD |
| author_sort | Cristina Pires Camargo, MD, PhD |
| collection | DOAJ |
| description | Background:. Approximately 80% of patients submitted to radiotherapy develop radiodermatitis. Photobiomodulation based on light-emitted diode (LED) is one of the therapeutic strategies for treating inflammation. This study aimed to investigate the effect of the photobiomodulation with two wavelengths, in an acute radiodermatitis animal model.
Methods:. Twenty rats were submitted to one radiotherapy session. After 15 days, the rats that developed radiodermatitis were divided into control groups, LED-630 nm, LED-850 nm, and LED-630 + 850 nm. The treatment regimen was one session lasting 10 minutes on alternate days for 21 days. We analyzed macroscopy aspects (RTOG scale), vascular density, dermal appendages, VEGF-a, TNF-alpha, MMP-9, and MMP-9 genic expression level.
Results:. All LED groups revealed a two-point reduction on the radiodermatitis severity grade compared with the baseline classification. Dermal appendage and vascular analysis showed a higher counting in all LED groups compared to control. This study showed dermal appendages twice in the 630/850 nm group compared with the control group. The 630/850 nm group showed six times more arterioles than the control group. Regarding genic expression, this study showed a 10-fold decrease between LED-630 nm versus LED-630 + 850 nm (P = 0.02) interleukin-10 expression and a 12-fold decrease between control versus LED-630 nm (P = 0.006) and LED-850 nm (P = 0.002) in TNF-alpha.
Conclusion:. LED (630 nm, 850 nm, and 630 nm + 850 nm) showed benefit in the treatment of radiodermatitis, and the association of the 630 nm + 850 nm and 630 nm parameters demonstrated the best macroscopic and microscopic results. |
| first_indexed | 2024-04-10T07:05:03Z |
| format | Article |
| id | doaj.art-7cb1f5d238e24eec8e867b4f9d854fc9 |
| institution | Directory Open Access Journal |
| issn | 2169-7574 |
| language | English |
| last_indexed | 2024-04-10T07:05:03Z |
| publishDate | 2023-02-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Plastic and Reconstructive Surgery, Global Open |
| spelling | doaj.art-7cb1f5d238e24eec8e867b4f9d854fc92023-02-27T09:02:01ZengWolters KluwerPlastic and Reconstructive Surgery, Global Open2169-75742023-02-01112e480910.1097/GOX.0000000000004809202302000-00002Effect of Photobiomodulation With Different Wavelengths on Radiodermatitis TreatmentCristina Pires Camargo, MD, PhD0Arturo Forner-Cordero, PhD1Bruna Matsumoto Silva, BEng2Vinícius Melo de Souza, BEng3Higor Souza Cunha, BEng4Yasmin de Oliveira Feitosa, BEng5Guilherme Arellano Campello, BEng6Pedro Henrique Gianjoppe dos Santos, BEng7Carolina Logo Rego, BEng8Heloisa Carvalho, MD, PhD9Rolf Gemperli, MD, PhD10From the * Microsurgery and Plastic Surgery Laboratory (LIM-04), School of Medicine, Universidade de São Paulo, São Paulo, Brazil† Biomechatronics Laboratory, Department of Mechatronics, Escola Politécnica da USP, Universidade de São Paulo, São Paulo, Brazil‡ Escola Politécnica, Universidade de São Paulo, São Paulo, Brazil‡ Escola Politécnica, Universidade de São Paulo, São Paulo, Brazil‡ Escola Politécnica, Universidade de São Paulo, São Paulo, Brazil‡ Escola Politécnica, Universidade de São Paulo, São Paulo, Brazil‡ Escola Politécnica, Universidade de São Paulo, São Paulo, Brazil‡ Escola Politécnica, Universidade de São Paulo, São Paulo, Brazil‡ Escola Politécnica, Universidade de São Paulo, São Paulo, Brazil§ Universidade de São Paulo, São Paulo, Brazil.From the * Microsurgery and Plastic Surgery Laboratory (LIM-04), School of Medicine, Universidade de São Paulo, São Paulo, BrazilBackground:. Approximately 80% of patients submitted to radiotherapy develop radiodermatitis. Photobiomodulation based on light-emitted diode (LED) is one of the therapeutic strategies for treating inflammation. This study aimed to investigate the effect of the photobiomodulation with two wavelengths, in an acute radiodermatitis animal model. Methods:. Twenty rats were submitted to one radiotherapy session. After 15 days, the rats that developed radiodermatitis were divided into control groups, LED-630 nm, LED-850 nm, and LED-630 + 850 nm. The treatment regimen was one session lasting 10 minutes on alternate days for 21 days. We analyzed macroscopy aspects (RTOG scale), vascular density, dermal appendages, VEGF-a, TNF-alpha, MMP-9, and MMP-9 genic expression level. Results:. All LED groups revealed a two-point reduction on the radiodermatitis severity grade compared with the baseline classification. Dermal appendage and vascular analysis showed a higher counting in all LED groups compared to control. This study showed dermal appendages twice in the 630/850 nm group compared with the control group. The 630/850 nm group showed six times more arterioles than the control group. Regarding genic expression, this study showed a 10-fold decrease between LED-630 nm versus LED-630 + 850 nm (P = 0.02) interleukin-10 expression and a 12-fold decrease between control versus LED-630 nm (P = 0.006) and LED-850 nm (P = 0.002) in TNF-alpha. Conclusion:. LED (630 nm, 850 nm, and 630 nm + 850 nm) showed benefit in the treatment of radiodermatitis, and the association of the 630 nm + 850 nm and 630 nm parameters demonstrated the best macroscopic and microscopic results.http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000004809 |
| spellingShingle | Cristina Pires Camargo, MD, PhD Arturo Forner-Cordero, PhD Bruna Matsumoto Silva, BEng Vinícius Melo de Souza, BEng Higor Souza Cunha, BEng Yasmin de Oliveira Feitosa, BEng Guilherme Arellano Campello, BEng Pedro Henrique Gianjoppe dos Santos, BEng Carolina Logo Rego, BEng Heloisa Carvalho, MD, PhD Rolf Gemperli, MD, PhD Effect of Photobiomodulation With Different Wavelengths on Radiodermatitis Treatment Plastic and Reconstructive Surgery, Global Open |
| title | Effect of Photobiomodulation With Different Wavelengths on Radiodermatitis Treatment |
| title_full | Effect of Photobiomodulation With Different Wavelengths on Radiodermatitis Treatment |
| title_fullStr | Effect of Photobiomodulation With Different Wavelengths on Radiodermatitis Treatment |
| title_full_unstemmed | Effect of Photobiomodulation With Different Wavelengths on Radiodermatitis Treatment |
| title_short | Effect of Photobiomodulation With Different Wavelengths on Radiodermatitis Treatment |
| title_sort | effect of photobiomodulation with different wavelengths on radiodermatitis treatment |
| url | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000004809 |
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