Synthesis of Hafnium(IV) Polyaminoacetates
The interaction of hafnium(IV) salts (oxide-dichloride, chloride, and bromide) with nitrilotriacetic acid (NTA), diethylenetriamminepentaacetic acid (DTPA), 1,2-diaminocyclohexanetetraacetic acid (CDTA), 1,3-dipropylmino-2-hydroxy <i>N</i>,<i>N</i>,<i>N</i>′,<i...
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2021-06-01
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author | Alexandra T. Shulyak Evgeniy O. Bortnikov Alexey S. Kubasov Nikita A. Selivanov Alexey A. Lipengolts Andrey P. Zhdanov Alexander Yu. Bykov Konstantin Yu. Zhizhin Nikolai T. Kuznetsov |
author_facet | Alexandra T. Shulyak Evgeniy O. Bortnikov Alexey S. Kubasov Nikita A. Selivanov Alexey A. Lipengolts Andrey P. Zhdanov Alexander Yu. Bykov Konstantin Yu. Zhizhin Nikolai T. Kuznetsov |
author_sort | Alexandra T. Shulyak |
collection | DOAJ |
description | The interaction of hafnium(IV) salts (oxide-dichloride, chloride, and bromide) with nitrilotriacetic acid (NTA), diethylenetriamminepentaacetic acid (DTPA), 1,2-diaminocyclohexanetetraacetic acid (CDTA), 1,3-dipropylmino-2-hydroxy <i>N</i>,<i>N</i>,<i>N</i>′,<i>N</i>′-tetraacetic acid (dpta), and <i>N</i>-(2-hydroxyethyl)ethylenediamine triacetic acid (HEDTA) has been studied. The corresponding complexes Na<sub>2</sub>[Hf(NTA)<sub>2</sub>]·3H<sub>2</sub>O (<b>1</b>), Na[HfDTPA]·3H<sub>2</sub>O (<b>2</b>), [HfCDTA(H<sub>2</sub>O)<sub>2</sub>] (<b>3</b>), and Na[Hf<sub>2</sub>(dpta)<sub>2</sub>]·7.5H<sub>2</sub>O·0.5C<sub>2</sub>H<sub>5</sub>OH (<b>4</b>) have been isolated and characterized and their structures have been determined by single crystal X-ray diffraction. Biological studies of [HfCDTA(H<sub>2</sub>O)<sub>2</sub>] have shown that in 5% glucose solution this complex has low toxicity and good contrasting ability. |
first_indexed | 2024-03-10T10:17:39Z |
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language | English |
last_indexed | 2024-03-10T10:17:39Z |
publishDate | 2021-06-01 |
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series | Molecules |
spelling | doaj.art-7cb4395e22bf43de8792102c23ee6b442023-11-22T00:43:31ZengMDPI AGMolecules1420-30492021-06-012612372510.3390/molecules26123725Synthesis of Hafnium(IV) PolyaminoacetatesAlexandra T. Shulyak0Evgeniy O. Bortnikov1Alexey S. Kubasov2Nikita A. Selivanov3Alexey A. Lipengolts4Andrey P. Zhdanov5Alexander Yu. Bykov6Konstantin Yu. Zhizhin7Nikolai T. Kuznetsov8Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskiy pr. 31, 119991 Moscow, RussiaOrganic Chemistry Department, Weizmann Institute of Science, 234 Herzl Street, Rehovot 7610001, IsraelKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskiy pr. 31, 119991 Moscow, RussiaKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskiy pr. 31, 119991 Moscow, RussiaN.N. Blokhin National Medical Research Center of Oncology, Federal State Budgetary Institution, Ministry of Health of the Russian Federation (N.N. Blokhin NMRCO), Kashirskoye Shosse 24, 115478 Moscow, RussiaKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskiy pr. 31, 119991 Moscow, RussiaKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskiy pr. 31, 119991 Moscow, RussiaKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskiy pr. 31, 119991 Moscow, RussiaKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskiy pr. 31, 119991 Moscow, RussiaThe interaction of hafnium(IV) salts (oxide-dichloride, chloride, and bromide) with nitrilotriacetic acid (NTA), diethylenetriamminepentaacetic acid (DTPA), 1,2-diaminocyclohexanetetraacetic acid (CDTA), 1,3-dipropylmino-2-hydroxy <i>N</i>,<i>N</i>,<i>N</i>′,<i>N</i>′-tetraacetic acid (dpta), and <i>N</i>-(2-hydroxyethyl)ethylenediamine triacetic acid (HEDTA) has been studied. The corresponding complexes Na<sub>2</sub>[Hf(NTA)<sub>2</sub>]·3H<sub>2</sub>O (<b>1</b>), Na[HfDTPA]·3H<sub>2</sub>O (<b>2</b>), [HfCDTA(H<sub>2</sub>O)<sub>2</sub>] (<b>3</b>), and Na[Hf<sub>2</sub>(dpta)<sub>2</sub>]·7.5H<sub>2</sub>O·0.5C<sub>2</sub>H<sub>5</sub>OH (<b>4</b>) have been isolated and characterized and their structures have been determined by single crystal X-ray diffraction. Biological studies of [HfCDTA(H<sub>2</sub>O)<sub>2</sub>] have shown that in 5% glucose solution this complex has low toxicity and good contrasting ability.https://www.mdpi.com/1420-3049/26/12/3725hafniumcomplexonatescoordination chemistryDTPAcontrast agentstructure elucidation |
spellingShingle | Alexandra T. Shulyak Evgeniy O. Bortnikov Alexey S. Kubasov Nikita A. Selivanov Alexey A. Lipengolts Andrey P. Zhdanov Alexander Yu. Bykov Konstantin Yu. Zhizhin Nikolai T. Kuznetsov Synthesis of Hafnium(IV) Polyaminoacetates Molecules hafnium complexonates coordination chemistry DTPA contrast agent structure elucidation |
title | Synthesis of Hafnium(IV) Polyaminoacetates |
title_full | Synthesis of Hafnium(IV) Polyaminoacetates |
title_fullStr | Synthesis of Hafnium(IV) Polyaminoacetates |
title_full_unstemmed | Synthesis of Hafnium(IV) Polyaminoacetates |
title_short | Synthesis of Hafnium(IV) Polyaminoacetates |
title_sort | synthesis of hafnium iv polyaminoacetates |
topic | hafnium complexonates coordination chemistry DTPA contrast agent structure elucidation |
url | https://www.mdpi.com/1420-3049/26/12/3725 |
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