Incorporating anti-infective drugs into peripherally inserted catheters does not reduce infection rates in neonates
PurposeThis study assesses whether peripherally inserted central venous catheters (PICC), impregnated with anti-infective drugs, reduce the rate of infections in neonates compared with unimpregnated catheters.MethodsA retrospective analysis was conducted on electronic patient records of neonates bor...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1255492/full |
| _version_ | 1797365515078860800 |
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| author | Julia Koppitz Julia Koppitz Rudolf Georg Ascherl Ulrich Herbert Thome Ferdinand Pulzer |
| author_facet | Julia Koppitz Julia Koppitz Rudolf Georg Ascherl Ulrich Herbert Thome Ferdinand Pulzer |
| author_sort | Julia Koppitz |
| collection | DOAJ |
| description | PurposeThis study assesses whether peripherally inserted central venous catheters (PICC), impregnated with anti-infective drugs, reduce the rate of infections in neonates compared with unimpregnated catheters.MethodsA retrospective analysis was conducted on electronic patient records of neonates born between August 2014 and May 2020, who had PICCs inserted, either standard (S-PICC) or with anti-infective drugs (A-PICC). Catheter-related bloodstream infections (CRBSI) were diagnosed based on clinical symptoms, laboratory results, and mentioning of infection in the patient record. Data on dwell time, mechanical ventilation, insertion site, maximum C-reactive protein (CRP) concentration, and anti-infective drug use were analyzed.ResultsA total of 223 PICCs were included. The infection rates were A-PICC (18.9%) and S-PICC (12.5%), which were not significantly different (p = 0.257). A-PICCs had significantly longer dwell times than S-PICCs (median 372 vs. 219 h, p = 0.004). The time to infection was not different between the groups (p = 0.3). There were also no significant differences in maximum CRP, insertion site abnormalities, or anti-infective drug use between the groups.ConclusionThis retrospective study did not find a significant reduction in infection rates by using PICCs containing anti-infective drugs in neonates. Current antibiotic impregnations do not seem to be effective in preventing blood stream infections. |
| first_indexed | 2024-03-08T16:51:06Z |
| format | Article |
| id | doaj.art-7cb463830b2047d59dc775a2f53178f5 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-08T16:51:06Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-7cb463830b2047d59dc775a2f53178f52024-01-05T04:37:46ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602024-01-011110.3389/fped.2023.12554921255492Incorporating anti-infective drugs into peripherally inserted catheters does not reduce infection rates in neonatesJulia Koppitz0Julia Koppitz1Rudolf Georg Ascherl2Ulrich Herbert Thome3Ferdinand Pulzer4Neonatologie, Universitätsklinikum Leipzig, Leipzig, GermanyKinder- und Jugendklinik, Universitätsmedizin Rostock, Rostock, GermanyNeonatologie, Universitätsklinikum Leipzig, Leipzig, GermanyNeonatologie, Universitätsklinikum Leipzig, Leipzig, GermanyNeonatologie, Universitätsklinikum Leipzig, Leipzig, GermanyPurposeThis study assesses whether peripherally inserted central venous catheters (PICC), impregnated with anti-infective drugs, reduce the rate of infections in neonates compared with unimpregnated catheters.MethodsA retrospective analysis was conducted on electronic patient records of neonates born between August 2014 and May 2020, who had PICCs inserted, either standard (S-PICC) or with anti-infective drugs (A-PICC). Catheter-related bloodstream infections (CRBSI) were diagnosed based on clinical symptoms, laboratory results, and mentioning of infection in the patient record. Data on dwell time, mechanical ventilation, insertion site, maximum C-reactive protein (CRP) concentration, and anti-infective drug use were analyzed.ResultsA total of 223 PICCs were included. The infection rates were A-PICC (18.9%) and S-PICC (12.5%), which were not significantly different (p = 0.257). A-PICCs had significantly longer dwell times than S-PICCs (median 372 vs. 219 h, p = 0.004). The time to infection was not different between the groups (p = 0.3). There were also no significant differences in maximum CRP, insertion site abnormalities, or anti-infective drug use between the groups.ConclusionThis retrospective study did not find a significant reduction in infection rates by using PICCs containing anti-infective drugs in neonates. Current antibiotic impregnations do not seem to be effective in preventing blood stream infections.https://www.frontiersin.org/articles/10.3389/fped.2023.1255492/fullneonatepretermcentral linecatheter-related infectionsmedicated catheters |
| spellingShingle | Julia Koppitz Julia Koppitz Rudolf Georg Ascherl Ulrich Herbert Thome Ferdinand Pulzer Incorporating anti-infective drugs into peripherally inserted catheters does not reduce infection rates in neonates Frontiers in Pediatrics neonate preterm central line catheter-related infections medicated catheters |
| title | Incorporating anti-infective drugs into peripherally inserted catheters does not reduce infection rates in neonates |
| title_full | Incorporating anti-infective drugs into peripherally inserted catheters does not reduce infection rates in neonates |
| title_fullStr | Incorporating anti-infective drugs into peripherally inserted catheters does not reduce infection rates in neonates |
| title_full_unstemmed | Incorporating anti-infective drugs into peripherally inserted catheters does not reduce infection rates in neonates |
| title_short | Incorporating anti-infective drugs into peripherally inserted catheters does not reduce infection rates in neonates |
| title_sort | incorporating anti infective drugs into peripherally inserted catheters does not reduce infection rates in neonates |
| topic | neonate preterm central line catheter-related infections medicated catheters |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1255492/full |
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