Use of low-field NMR for the characterization of gels and biological tissues
The focus of this paper is on the theoretical interpretation of Low Field Nuclear Magnetic Resonance (LF-NMR) data regarding hydrogels architecture and on the most interesting applications of LF-NMR presented by this research group at the 6th IAPC Symposium held in Zagreb (HR) on September 2017. Par...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
International Association of Physical Chemists (IAPC)
2018-03-01
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| Series: | ADMET and DMPK |
| Subjects: | |
| Online Access: | http://pub.iapchem.org/ojs/index.php/admet/article/view/430 |
| _version_ | 1819135196690120704 |
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| author | Michela Abrami Gianluca Chiarappa Rossella Farra Gabriele Grassi Paolo Marizza Mario Grassi |
| author_facet | Michela Abrami Gianluca Chiarappa Rossella Farra Gabriele Grassi Paolo Marizza Mario Grassi |
| author_sort | Michela Abrami |
| collection | DOAJ |
| description | The focus of this paper is on the theoretical interpretation of Low Field Nuclear Magnetic Resonance (LF-NMR) data regarding hydrogels architecture and on the most interesting applications of LF-NMR presented by this research group at the 6th IAPC Symposium held in Zagreb (HR) on September 2017. Particular attention is devoted to the determination of the mesh size distribution of gels polymeric network and the determination of the pore size distribution of microporous systems such as scaffolds, bones, and porous gels. In addition, we report on a very recent application of LF-NMR for monitoring lung functioning in patients suffering from chronic pulmonary diseases like cystic fibrosis. The main findings of this work consist in providing a very simple and accurate approximation of a general theory devoted to evaluating the relation existing among four fundamental polymeric network parameters, i.e. the polymer volume fraction inside the hydrogel, mesh size, hydraulic radius, and the radius of the cylinder ideally embedding each polymeric network chain. Furthermore, we demonstrated the potentiality of LF-NMR in the characterization of different polymeric systems among which the sputum of patients suffering from chronic pulmonary diseases appears the most innovative application for its simplicity, rapidity, effectiveness, and potential impact in the everyday clinic. |
| first_indexed | 2024-12-22T10:15:15Z |
| format | Article |
| id | doaj.art-7cb504f243334c62a13ddf5e333b6751 |
| institution | Directory Open Access Journal |
| issn | 1848-7718 |
| language | English |
| last_indexed | 2024-12-22T10:15:15Z |
| publishDate | 2018-03-01 |
| publisher | International Association of Physical Chemists (IAPC) |
| record_format | Article |
| series | ADMET and DMPK |
| spelling | doaj.art-7cb504f243334c62a13ddf5e333b67512022-12-21T18:29:45ZengInternational Association of Physical Chemists (IAPC)ADMET and DMPK1848-77182018-03-0161344610.5599/admet.6.1.430298Use of low-field NMR for the characterization of gels and biological tissuesMichela Abrami0Gianluca Chiarappa1Rossella Farra2Gabriele Grassi3Paolo Marizza4Mario Grassi5University of Trieste, Dept of Engineering and ArchitectureUniversity of Trieste, Dept of Engineering and ArchitectureUniversity of Trieste, Dept of Engineering and ArchitectureDepartment of Life Sciences, Trieste UniversityDepartment of Micro- and Nanotechnology, Technical University of DenmarkTrieste University - Department of Engineering and ArchiterctureThe focus of this paper is on the theoretical interpretation of Low Field Nuclear Magnetic Resonance (LF-NMR) data regarding hydrogels architecture and on the most interesting applications of LF-NMR presented by this research group at the 6th IAPC Symposium held in Zagreb (HR) on September 2017. Particular attention is devoted to the determination of the mesh size distribution of gels polymeric network and the determination of the pore size distribution of microporous systems such as scaffolds, bones, and porous gels. In addition, we report on a very recent application of LF-NMR for monitoring lung functioning in patients suffering from chronic pulmonary diseases like cystic fibrosis. The main findings of this work consist in providing a very simple and accurate approximation of a general theory devoted to evaluating the relation existing among four fundamental polymeric network parameters, i.e. the polymer volume fraction inside the hydrogel, mesh size, hydraulic radius, and the radius of the cylinder ideally embedding each polymeric network chain. Furthermore, we demonstrated the potentiality of LF-NMR in the characterization of different polymeric systems among which the sputum of patients suffering from chronic pulmonary diseases appears the most innovative application for its simplicity, rapidity, effectiveness, and potential impact in the everyday clinic.http://pub.iapchem.org/ojs/index.php/admet/article/view/430Low Field NMR, biomedical applications |
| spellingShingle | Michela Abrami Gianluca Chiarappa Rossella Farra Gabriele Grassi Paolo Marizza Mario Grassi Use of low-field NMR for the characterization of gels and biological tissues ADMET and DMPK Low Field NMR, biomedical applications |
| title | Use of low-field NMR for the characterization of gels and biological tissues |
| title_full | Use of low-field NMR for the characterization of gels and biological tissues |
| title_fullStr | Use of low-field NMR for the characterization of gels and biological tissues |
| title_full_unstemmed | Use of low-field NMR for the characterization of gels and biological tissues |
| title_short | Use of low-field NMR for the characterization of gels and biological tissues |
| title_sort | use of low field nmr for the characterization of gels and biological tissues |
| topic | Low Field NMR, biomedical applications |
| url | http://pub.iapchem.org/ojs/index.php/admet/article/view/430 |
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