Glycosaminoglycan-Based Cryogels as Scaffolds for Cell Cultivation and Tissue Regeneration
Cryogels are a class of macroporous, interconnective hydrogels polymerized at sub-zero temperatures forming mechanically robust, elastic networks. In this review, latest advances of cryogels containing mainly glycosaminoglycans (GAGs) or composites of GAGs and other natural or synthetic polymers are...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/18/5597 |
| _version_ | 1797518014430576640 |
|---|---|
| author | Annika Wartenberg Jürgen Weisser Matthias Schnabelrauch |
| author_facet | Annika Wartenberg Jürgen Weisser Matthias Schnabelrauch |
| author_sort | Annika Wartenberg |
| collection | DOAJ |
| description | Cryogels are a class of macroporous, interconnective hydrogels polymerized at sub-zero temperatures forming mechanically robust, elastic networks. In this review, latest advances of cryogels containing mainly glycosaminoglycans (GAGs) or composites of GAGs and other natural or synthetic polymers are presented. Cryogels produced in this way correspond to the native extracellular matrix (ECM) in terms of both composition and molecular structure. Due to their specific structural feature and in addition to an excellent biocompatibility, GAG-based cryogels have several advantages over traditional GAG-hydrogels. This includes macroporous, interconnective pore structure, robust, elastic, and shape-memory-like mechanical behavior, as well as injectability for many GAG-based cryogels. After addressing the cryogelation process, the fabrication of GAG-based cryogels and known principles of GAG monomer crosslinking are discussed. Finally, an overview of specific GAG-based cryogels in biomedicine, mainly as polymeric scaffold material in tissue regeneration and tissue engineering-related controlled release of bioactive molecules and cells, is provided. |
| first_indexed | 2024-03-10T07:24:14Z |
| format | Article |
| id | doaj.art-7cb6c1f8059642059f867b42979411c5 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T07:24:14Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-7cb6c1f8059642059f867b42979411c52023-11-22T14:25:32ZengMDPI AGMolecules1420-30492021-09-012618559710.3390/molecules26185597Glycosaminoglycan-Based Cryogels as Scaffolds for Cell Cultivation and Tissue RegenerationAnnika Wartenberg0Jürgen Weisser1Matthias Schnabelrauch2Biomaterials Department, INNOVENT e.V., Pruessingstrasse 27B, 07745 Jena, GermanyBiomaterials Department, INNOVENT e.V., Pruessingstrasse 27B, 07745 Jena, GermanyBiomaterials Department, INNOVENT e.V., Pruessingstrasse 27B, 07745 Jena, GermanyCryogels are a class of macroporous, interconnective hydrogels polymerized at sub-zero temperatures forming mechanically robust, elastic networks. In this review, latest advances of cryogels containing mainly glycosaminoglycans (GAGs) or composites of GAGs and other natural or synthetic polymers are presented. Cryogels produced in this way correspond to the native extracellular matrix (ECM) in terms of both composition and molecular structure. Due to their specific structural feature and in addition to an excellent biocompatibility, GAG-based cryogels have several advantages over traditional GAG-hydrogels. This includes macroporous, interconnective pore structure, robust, elastic, and shape-memory-like mechanical behavior, as well as injectability for many GAG-based cryogels. After addressing the cryogelation process, the fabrication of GAG-based cryogels and known principles of GAG monomer crosslinking are discussed. Finally, an overview of specific GAG-based cryogels in biomedicine, mainly as polymeric scaffold material in tissue regeneration and tissue engineering-related controlled release of bioactive molecules and cells, is provided.https://www.mdpi.com/1420-3049/26/18/5597cryogelscell scaffoldstissue engineeringglycosaminoglycanshyaluronanchondroitin sulfate |
| spellingShingle | Annika Wartenberg Jürgen Weisser Matthias Schnabelrauch Glycosaminoglycan-Based Cryogels as Scaffolds for Cell Cultivation and Tissue Regeneration Molecules cryogels cell scaffolds tissue engineering glycosaminoglycans hyaluronan chondroitin sulfate |
| title | Glycosaminoglycan-Based Cryogels as Scaffolds for Cell Cultivation and Tissue Regeneration |
| title_full | Glycosaminoglycan-Based Cryogels as Scaffolds for Cell Cultivation and Tissue Regeneration |
| title_fullStr | Glycosaminoglycan-Based Cryogels as Scaffolds for Cell Cultivation and Tissue Regeneration |
| title_full_unstemmed | Glycosaminoglycan-Based Cryogels as Scaffolds for Cell Cultivation and Tissue Regeneration |
| title_short | Glycosaminoglycan-Based Cryogels as Scaffolds for Cell Cultivation and Tissue Regeneration |
| title_sort | glycosaminoglycan based cryogels as scaffolds for cell cultivation and tissue regeneration |
| topic | cryogels cell scaffolds tissue engineering glycosaminoglycans hyaluronan chondroitin sulfate |
| url | https://www.mdpi.com/1420-3049/26/18/5597 |
| work_keys_str_mv | AT annikawartenberg glycosaminoglycanbasedcryogelsasscaffoldsforcellcultivationandtissueregeneration AT jurgenweisser glycosaminoglycanbasedcryogelsasscaffoldsforcellcultivationandtissueregeneration AT matthiasschnabelrauch glycosaminoglycanbasedcryogelsasscaffoldsforcellcultivationandtissueregeneration |