Adult neurogenesis in crayfish: Identity and regulation of neural progenitors produced by the immune system
Summary: Adult-born neurons are incorporated into brain circuits in the crayfish Procambarus clarkii, as in many vertebrate and invertebrate species. Adult neurogenesis depends on several conserved features, including the presence of neurogenic niches housing progenitor cells and the expansion, migr...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-04-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222002632 |
| _version_ | 1818774463849693184 |
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| author | Jeanne L. Benton Emmy Li Emily Weisbach Yuriko Fukumura Virginia C. Quinan Paula Grazielle Chaves da Silva Alex J. Edwards Barbara S. Beltz |
| author_facet | Jeanne L. Benton Emmy Li Emily Weisbach Yuriko Fukumura Virginia C. Quinan Paula Grazielle Chaves da Silva Alex J. Edwards Barbara S. Beltz |
| author_sort | Jeanne L. Benton |
| collection | DOAJ |
| description | Summary: Adult-born neurons are incorporated into brain circuits in the crayfish Procambarus clarkii, as in many vertebrate and invertebrate species. Adult neurogenesis depends on several conserved features, including the presence of neurogenic niches housing progenitor cells and the expansion, migration, and differentiation of their daughters, the neural precursor cells. However, in contrast to mammalian species, the progenitors initiating the neurogenic lineage in P. clarkii do not undergo long-term self-renewal. A central question is the mode of replenishment of these cells. Experiments have shown that hemocytes generated by the immune system, and not other cell types, are attracted to and incorporated into the niche. The present studies highlight the interdependency of the immune and nervous systems in the generation of adult-born neurons, by demonstrating that hyaline hemocytes are the probable neural progenitor cells, and that serotonin and the cytokine astakine 1 regulate both immune function and adult neurogenesis. |
| first_indexed | 2024-12-18T10:41:33Z |
| format | Article |
| id | doaj.art-7cb78dfa1bac44e1b29b3631267d6f8a |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-18T10:41:33Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-7cb78dfa1bac44e1b29b3631267d6f8a2022-12-21T21:10:37ZengElsevieriScience2589-00422022-04-01254103993Adult neurogenesis in crayfish: Identity and regulation of neural progenitors produced by the immune systemJeanne L. Benton0Emmy Li1Emily Weisbach2Yuriko Fukumura3Virginia C. Quinan4Paula Grazielle Chaves da Silva5Alex J. Edwards6Barbara S. Beltz7Neuroscience Department, Wellesley College, Wellesley, MA 02481, USANeuroscience Department, Wellesley College, Wellesley, MA 02481, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94158, USANeuroscience Department, Wellesley College, Wellesley, MA 02481, USA; Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USANeuroscience Department, Wellesley College, Wellesley, MA 02481, USANeuroscience Department, Wellesley College, Wellesley, MA 02481, USANeuroscience Department, Wellesley College, Wellesley, MA 02481, USANeuroscience Department, Wellesley College, Wellesley, MA 02481, USANeuroscience Department, Wellesley College, Wellesley, MA 02481, USA; Corresponding authorSummary: Adult-born neurons are incorporated into brain circuits in the crayfish Procambarus clarkii, as in many vertebrate and invertebrate species. Adult neurogenesis depends on several conserved features, including the presence of neurogenic niches housing progenitor cells and the expansion, migration, and differentiation of their daughters, the neural precursor cells. However, in contrast to mammalian species, the progenitors initiating the neurogenic lineage in P. clarkii do not undergo long-term self-renewal. A central question is the mode of replenishment of these cells. Experiments have shown that hemocytes generated by the immune system, and not other cell types, are attracted to and incorporated into the niche. The present studies highlight the interdependency of the immune and nervous systems in the generation of adult-born neurons, by demonstrating that hyaline hemocytes are the probable neural progenitor cells, and that serotonin and the cytokine astakine 1 regulate both immune function and adult neurogenesis.http://www.sciencedirect.com/science/article/pii/S2589004222002632Biological sciencesneuroscienceimmunology |
| spellingShingle | Jeanne L. Benton Emmy Li Emily Weisbach Yuriko Fukumura Virginia C. Quinan Paula Grazielle Chaves da Silva Alex J. Edwards Barbara S. Beltz Adult neurogenesis in crayfish: Identity and regulation of neural progenitors produced by the immune system iScience Biological sciences neuroscience immunology |
| title | Adult neurogenesis in crayfish: Identity and regulation of neural progenitors produced by the immune system |
| title_full | Adult neurogenesis in crayfish: Identity and regulation of neural progenitors produced by the immune system |
| title_fullStr | Adult neurogenesis in crayfish: Identity and regulation of neural progenitors produced by the immune system |
| title_full_unstemmed | Adult neurogenesis in crayfish: Identity and regulation of neural progenitors produced by the immune system |
| title_short | Adult neurogenesis in crayfish: Identity and regulation of neural progenitors produced by the immune system |
| title_sort | adult neurogenesis in crayfish identity and regulation of neural progenitors produced by the immune system |
| topic | Biological sciences neuroscience immunology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004222002632 |
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