Neuroimaging studies of cannabidiol and potential neurobiological mechanisms relevant for alcohol use disorders: a systematic review
Abstract The underlying neurobiological mechanisms of cannabidiol’s (CBD) management of alcohol use disorder (AUD) remains elusive. Aim We conducted a systematic review of neuroimaging literature investigating the effects of CBD on the brain in healthy participants. We then theorise the potential ne...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-03-01
|
| Series: | Journal of Cannabis Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42238-024-00224-0 |
| _version_ | 1797247073263812608 |
|---|---|
| author | Tristan Hurzeler Joshua Watt Warren Logge Ellen Towers Anastasia Suraev Nicholas Lintzeris Paul Haber Kirsten C. Morley |
| author_facet | Tristan Hurzeler Joshua Watt Warren Logge Ellen Towers Anastasia Suraev Nicholas Lintzeris Paul Haber Kirsten C. Morley |
| author_sort | Tristan Hurzeler |
| collection | DOAJ |
| description | Abstract The underlying neurobiological mechanisms of cannabidiol’s (CBD) management of alcohol use disorder (AUD) remains elusive. Aim We conducted a systematic review of neuroimaging literature investigating the effects of CBD on the brain in healthy participants. We then theorise the potential neurobiological mechanisms by which CBD may ameliorate various symptoms of AUD. Methods This review was conducted according to the PRISMA guidelines. Terms relating to CBD and neuroimaging were used to search original clinical research published in peer-reviewed journals. Results Of 767 studies identified by our search strategy, 16 studies satisfied our eligibility criteria. The results suggest that CBD modulates γ-Aminobutyric acid and glutamate signaling in the basal ganglia and dorso-medial prefrontal cortex. Furthermore, CBD regulates activity in regions associated with mesocorticolimbic reward pathways; salience, limbic and fronto-striatal networks which are implicated in reward anticipation; emotion regulation; salience processing; and executive functioning. Conclusion CBD appears to modulate neurotransmitter systems and functional connections in brain regions implicated in AUD, suggesting CBD may be used to manage AUD symptomatology. |
| first_indexed | 2024-04-24T19:52:53Z |
| format | Article |
| id | doaj.art-7cb8a5756ed24de38f3868e6be8b8c6b |
| institution | Directory Open Access Journal |
| issn | 2522-5782 |
| language | English |
| last_indexed | 2024-04-24T19:52:53Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cannabis Research |
| spelling | doaj.art-7cb8a5756ed24de38f3868e6be8b8c6b2024-03-24T12:32:32ZengBMCJournal of Cannabis Research2522-57822024-03-016112110.1186/s42238-024-00224-0Neuroimaging studies of cannabidiol and potential neurobiological mechanisms relevant for alcohol use disorders: a systematic reviewTristan Hurzeler0Joshua Watt1Warren Logge2Ellen Towers3Anastasia Suraev4Nicholas Lintzeris5Paul Haber6Kirsten C. Morley7Faculty of Medicine and Health, University of SydneyTranslational Research in Alcohol, Edith Collins Centre, Sydney Local Health DistrictFaculty of Medicine and Health, University of SydneyFaculty of Medicine and Health, University of SydneyLambert Initiative for Cannabinoid Therapeutics, University of SydneyFaculty of Medicine and Health, University of SydneyFaculty of Medicine and Health, University of SydneyFaculty of Medicine and Health, University of SydneyAbstract The underlying neurobiological mechanisms of cannabidiol’s (CBD) management of alcohol use disorder (AUD) remains elusive. Aim We conducted a systematic review of neuroimaging literature investigating the effects of CBD on the brain in healthy participants. We then theorise the potential neurobiological mechanisms by which CBD may ameliorate various symptoms of AUD. Methods This review was conducted according to the PRISMA guidelines. Terms relating to CBD and neuroimaging were used to search original clinical research published in peer-reviewed journals. Results Of 767 studies identified by our search strategy, 16 studies satisfied our eligibility criteria. The results suggest that CBD modulates γ-Aminobutyric acid and glutamate signaling in the basal ganglia and dorso-medial prefrontal cortex. Furthermore, CBD regulates activity in regions associated with mesocorticolimbic reward pathways; salience, limbic and fronto-striatal networks which are implicated in reward anticipation; emotion regulation; salience processing; and executive functioning. Conclusion CBD appears to modulate neurotransmitter systems and functional connections in brain regions implicated in AUD, suggesting CBD may be used to manage AUD symptomatology.https://doi.org/10.1186/s42238-024-00224-0CannabidiolNeuroimagingPETAlcohol use disorderPharmacotherapy |
| spellingShingle | Tristan Hurzeler Joshua Watt Warren Logge Ellen Towers Anastasia Suraev Nicholas Lintzeris Paul Haber Kirsten C. Morley Neuroimaging studies of cannabidiol and potential neurobiological mechanisms relevant for alcohol use disorders: a systematic review Journal of Cannabis Research Cannabidiol Neuroimaging PET Alcohol use disorder Pharmacotherapy |
| title | Neuroimaging studies of cannabidiol and potential neurobiological mechanisms relevant for alcohol use disorders: a systematic review |
| title_full | Neuroimaging studies of cannabidiol and potential neurobiological mechanisms relevant for alcohol use disorders: a systematic review |
| title_fullStr | Neuroimaging studies of cannabidiol and potential neurobiological mechanisms relevant for alcohol use disorders: a systematic review |
| title_full_unstemmed | Neuroimaging studies of cannabidiol and potential neurobiological mechanisms relevant for alcohol use disorders: a systematic review |
| title_short | Neuroimaging studies of cannabidiol and potential neurobiological mechanisms relevant for alcohol use disorders: a systematic review |
| title_sort | neuroimaging studies of cannabidiol and potential neurobiological mechanisms relevant for alcohol use disorders a systematic review |
| topic | Cannabidiol Neuroimaging PET Alcohol use disorder Pharmacotherapy |
| url | https://doi.org/10.1186/s42238-024-00224-0 |
| work_keys_str_mv | AT tristanhurzeler neuroimagingstudiesofcannabidiolandpotentialneurobiologicalmechanismsrelevantforalcoholusedisordersasystematicreview AT joshuawatt neuroimagingstudiesofcannabidiolandpotentialneurobiologicalmechanismsrelevantforalcoholusedisordersasystematicreview AT warrenlogge neuroimagingstudiesofcannabidiolandpotentialneurobiologicalmechanismsrelevantforalcoholusedisordersasystematicreview AT ellentowers neuroimagingstudiesofcannabidiolandpotentialneurobiologicalmechanismsrelevantforalcoholusedisordersasystematicreview AT anastasiasuraev neuroimagingstudiesofcannabidiolandpotentialneurobiologicalmechanismsrelevantforalcoholusedisordersasystematicreview AT nicholaslintzeris neuroimagingstudiesofcannabidiolandpotentialneurobiologicalmechanismsrelevantforalcoholusedisordersasystematicreview AT paulhaber neuroimagingstudiesofcannabidiolandpotentialneurobiologicalmechanismsrelevantforalcoholusedisordersasystematicreview AT kirstencmorley neuroimagingstudiesofcannabidiolandpotentialneurobiologicalmechanismsrelevantforalcoholusedisordersasystematicreview |