Role of Mitofusins and Mitophagy in Life or Death Decisions
Mitochondria entail an incredible dynamism in their morphology, impacting death signaling and selective elimination of the damaged organelles. In turn, by recycling the superfluous or malfunctioning mitochondria, mostly prevalent during aging, mitophagy contributes to maintain a healthy mitochondria...
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2020.572182/full |
| _version_ | 1818548383720144896 |
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| author | Mariana Joaquim Mafalda Escobar-Henriques |
| author_facet | Mariana Joaquim Mafalda Escobar-Henriques |
| author_sort | Mariana Joaquim |
| collection | DOAJ |
| description | Mitochondria entail an incredible dynamism in their morphology, impacting death signaling and selective elimination of the damaged organelles. In turn, by recycling the superfluous or malfunctioning mitochondria, mostly prevalent during aging, mitophagy contributes to maintain a healthy mitochondrial network. Mitofusins locate at the outer mitochondrial membrane and control the plastic behavior of mitochondria, by mediating fusion events. Besides deciding on mitochondrial interconnectivity, mitofusin 2 regulates physical contacts between mitochondria and the endoplasmic reticulum, but also serves as a decisive docking platform for mitophagy and apoptosis effectors. Thus, mitofusins integrate multiple bidirectional inputs from and into mitochondria and ensure proper energetic and metabolic cellular performance. Here, we review the role of mitofusins and mitophagy at the cross-road between life and apoptotic death decisions. Furthermore, we highlight the impact of this interplay on disease, focusing on how mitofusin 2 and mitophagy affect non-alcoholic fatty liver disease. |
| first_indexed | 2024-12-12T08:19:12Z |
| format | Article |
| id | doaj.art-7cb8a5888f0a44eabc749eddde99b0e8 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-12T08:19:12Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-7cb8a5888f0a44eabc749eddde99b0e82022-12-22T00:31:27ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-09-01810.3389/fcell.2020.572182572182Role of Mitofusins and Mitophagy in Life or Death DecisionsMariana JoaquimMafalda Escobar-HenriquesMitochondria entail an incredible dynamism in their morphology, impacting death signaling and selective elimination of the damaged organelles. In turn, by recycling the superfluous or malfunctioning mitochondria, mostly prevalent during aging, mitophagy contributes to maintain a healthy mitochondrial network. Mitofusins locate at the outer mitochondrial membrane and control the plastic behavior of mitochondria, by mediating fusion events. Besides deciding on mitochondrial interconnectivity, mitofusin 2 regulates physical contacts between mitochondria and the endoplasmic reticulum, but also serves as a decisive docking platform for mitophagy and apoptosis effectors. Thus, mitofusins integrate multiple bidirectional inputs from and into mitochondria and ensure proper energetic and metabolic cellular performance. Here, we review the role of mitofusins and mitophagy at the cross-road between life and apoptotic death decisions. Furthermore, we highlight the impact of this interplay on disease, focusing on how mitofusin 2 and mitophagy affect non-alcoholic fatty liver disease.https://www.frontiersin.org/article/10.3389/fcell.2020.572182/fullmitochondriamitofusinsMFN2mitophagyapoptosisNAFLD |
| spellingShingle | Mariana Joaquim Mafalda Escobar-Henriques Role of Mitofusins and Mitophagy in Life or Death Decisions Frontiers in Cell and Developmental Biology mitochondria mitofusins MFN2 mitophagy apoptosis NAFLD |
| title | Role of Mitofusins and Mitophagy in Life or Death Decisions |
| title_full | Role of Mitofusins and Mitophagy in Life or Death Decisions |
| title_fullStr | Role of Mitofusins and Mitophagy in Life or Death Decisions |
| title_full_unstemmed | Role of Mitofusins and Mitophagy in Life or Death Decisions |
| title_short | Role of Mitofusins and Mitophagy in Life or Death Decisions |
| title_sort | role of mitofusins and mitophagy in life or death decisions |
| topic | mitochondria mitofusins MFN2 mitophagy apoptosis NAFLD |
| url | https://www.frontiersin.org/article/10.3389/fcell.2020.572182/full |
| work_keys_str_mv | AT marianajoaquim roleofmitofusinsandmitophagyinlifeordeathdecisions AT mafaldaescobarhenriques roleofmitofusinsandmitophagyinlifeordeathdecisions |