Early Depression Independently of Other Neuropsychiatric Conditions, Influences Disability and Mortality after Stroke (Research Study—Part of PROPOLIS Study)
Post-stroke depression (PSD) is the most frequent neuropsychiatric consequence of stroke. The nature of the relationship between PSD and mortality still remains unknown. One hypothesis is that PSD could be more frequent in those patients who are more vulnerable to physical disability, a mediator var...
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| Format: | Article |
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MDPI AG
2020-11-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/8/11/509 |
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| author | Katarzyna Kowalska Łukasz Krzywoszański Jakub Droś Paulina Pasińska Aleksander Wilk Aleksandra Klimkowicz-Mrowiec |
| author_facet | Katarzyna Kowalska Łukasz Krzywoszański Jakub Droś Paulina Pasińska Aleksander Wilk Aleksandra Klimkowicz-Mrowiec |
| author_sort | Katarzyna Kowalska |
| collection | DOAJ |
| description | Post-stroke depression (PSD) is the most frequent neuropsychiatric consequence of stroke. The nature of the relationship between PSD and mortality still remains unknown. One hypothesis is that PSD could be more frequent in those patients who are more vulnerable to physical disability, a mediator variable for higher level of physical damage related to higher risk of mortality. Therefore, the authors’ objective was to explore the assumption that PSD increases disability after stroke, and secondly, that mortality is higher among patients with PSD regardless of stroke severity and other neuropsychiatric conditions. We included 524 consecutive patients with acute stroke or transient ischemic attack, who were screened for depression between 7–10 days after stroke onset. Physical impairment and death were the outcomes measures at evaluation check points three and 12 months post-stroke. PSD independently increased the level of disability three (OR = 1.94, 95% CI 1.31–2.87, <i>p</i> = 0.001), and 12 months post-stroke (OR = 1.61, 95% CI 1.14–2.48, <i>p</i> = 0.009). PSD was also an independent risk factor for death three (OR = 5.68, 95% CI 1.58–20.37, <i>p</i> = 0.008) and 12 months after stroke (OR = 4.53, 95% CI 2.06–9.94, <i>p</i> = 0.001). Our study shows the negative impact of early PSD on the level of disability and survival rates during first year after stroke and supports the assumption that depression may act as an independent mediator for disability leading to death in patients who are more vulnerable for brain injury. |
| first_indexed | 2024-03-10T14:46:50Z |
| format | Article |
| id | doaj.art-7cb99d5b5a3945e5a3a728541a026d11 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T14:46:50Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-7cb99d5b5a3945e5a3a728541a026d112023-11-20T21:17:15ZengMDPI AGBiomedicines2227-90592020-11-0181150910.3390/biomedicines8110509Early Depression Independently of Other Neuropsychiatric Conditions, Influences Disability and Mortality after Stroke (Research Study—Part of PROPOLIS Study)Katarzyna Kowalska0Łukasz Krzywoszański1Jakub Droś2Paulina Pasińska3Aleksander Wilk4Aleksandra Klimkowicz-Mrowiec5Department of Neurology, Faculty of Medicine, Jagiellonian University Medical College, 31-008 Kraków, PolandInstitute of Psychology, Pedagogical University of Krakow, 30-084 Kraków, PolandDoctoral School in Medical and Health Sciences, Jagiellonian University Medical College, 31-008 Kraków, PolandDepartment of Medical Didactics, Faculty of Medicine, Jagiellonian University Medical College, 31-008 Kraków, PolandDepartment of Neurosurgery, University Hospital, 30-688 Kraków, PolandDepartment of Neurology, Faculty of Medicine, Jagiellonian University Medical College, 31-008 Kraków, PolandPost-stroke depression (PSD) is the most frequent neuropsychiatric consequence of stroke. The nature of the relationship between PSD and mortality still remains unknown. One hypothesis is that PSD could be more frequent in those patients who are more vulnerable to physical disability, a mediator variable for higher level of physical damage related to higher risk of mortality. Therefore, the authors’ objective was to explore the assumption that PSD increases disability after stroke, and secondly, that mortality is higher among patients with PSD regardless of stroke severity and other neuropsychiatric conditions. We included 524 consecutive patients with acute stroke or transient ischemic attack, who were screened for depression between 7–10 days after stroke onset. Physical impairment and death were the outcomes measures at evaluation check points three and 12 months post-stroke. PSD independently increased the level of disability three (OR = 1.94, 95% CI 1.31–2.87, <i>p</i> = 0.001), and 12 months post-stroke (OR = 1.61, 95% CI 1.14–2.48, <i>p</i> = 0.009). PSD was also an independent risk factor for death three (OR = 5.68, 95% CI 1.58–20.37, <i>p</i> = 0.008) and 12 months after stroke (OR = 4.53, 95% CI 2.06–9.94, <i>p</i> = 0.001). Our study shows the negative impact of early PSD on the level of disability and survival rates during first year after stroke and supports the assumption that depression may act as an independent mediator for disability leading to death in patients who are more vulnerable for brain injury.https://www.mdpi.com/2227-9059/8/11/509post-stroke depressiondisability levelmortality |
| spellingShingle | Katarzyna Kowalska Łukasz Krzywoszański Jakub Droś Paulina Pasińska Aleksander Wilk Aleksandra Klimkowicz-Mrowiec Early Depression Independently of Other Neuropsychiatric Conditions, Influences Disability and Mortality after Stroke (Research Study—Part of PROPOLIS Study) Biomedicines post-stroke depression disability level mortality |
| title | Early Depression Independently of Other Neuropsychiatric Conditions, Influences Disability and Mortality after Stroke (Research Study—Part of PROPOLIS Study) |
| title_full | Early Depression Independently of Other Neuropsychiatric Conditions, Influences Disability and Mortality after Stroke (Research Study—Part of PROPOLIS Study) |
| title_fullStr | Early Depression Independently of Other Neuropsychiatric Conditions, Influences Disability and Mortality after Stroke (Research Study—Part of PROPOLIS Study) |
| title_full_unstemmed | Early Depression Independently of Other Neuropsychiatric Conditions, Influences Disability and Mortality after Stroke (Research Study—Part of PROPOLIS Study) |
| title_short | Early Depression Independently of Other Neuropsychiatric Conditions, Influences Disability and Mortality after Stroke (Research Study—Part of PROPOLIS Study) |
| title_sort | early depression independently of other neuropsychiatric conditions influences disability and mortality after stroke research study part of propolis study |
| topic | post-stroke depression disability level mortality |
| url | https://www.mdpi.com/2227-9059/8/11/509 |
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