Degenerative osteoarthritis a reversible chronic disease
Osteoarthritis (OA) is the most common chronic musculoskeletal disorder. It can affect any joint and is the most frequent single cause of disability in older adults.OA is a progressive degenerative disease involving the entire joint structure in a vicious circle that includes the capsule-bursa tissu...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | Regenerative Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320420300651 |
| _version_ | 1818610965059469312 |
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| author | V. Di Nicola |
| author_facet | V. Di Nicola |
| author_sort | V. Di Nicola |
| collection | DOAJ |
| description | Osteoarthritis (OA) is the most common chronic musculoskeletal disorder. It can affect any joint and is the most frequent single cause of disability in older adults.OA is a progressive degenerative disease involving the entire joint structure in a vicious circle that includes the capsule-bursa tissue inflammation, synovial fluid modifications, cartilage breakdown and erosions, osteochondral inflammatory damage leading to bone erosion and distortion.Research has identified the initial inflammatory-immunologic process that starts this vicious cycle leading to so-called early OA. Research has also identified the role played in the disease advancement by synoviocytes type A and B, chondrocytes, extracellular matrix, local immune-inflammatory mediators and proteases.This article investigates the joint-resident MSCs that play an essential local homeostatic role and regulate cell turn over and tissue repair. Resident MSCs establish and maintain a local regenerative microenvironment.The understanding of OA physiopathology clarifies the core mechanisms by which minimally invasive interventions might be able to halt and reverse the course of early stage OA. Interventions employing PRP, MSCs and exosomes are considered in this article. |
| first_indexed | 2024-12-16T15:22:48Z |
| format | Article |
| id | doaj.art-7cbadd63ff4c481180a2ab6d5f535b0f |
| institution | Directory Open Access Journal |
| issn | 2352-3204 |
| language | English |
| last_indexed | 2024-12-16T15:22:48Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj.art-7cbadd63ff4c481180a2ab6d5f535b0f2022-12-21T22:26:34ZengElsevierRegenerative Therapy2352-32042020-12-0115149160Degenerative osteoarthritis a reversible chronic diseaseV. Di Nicola0West Sussex Hospitals NHS Foundation Trust, Worthing Hospital, BN112DH, UK; Regenerative Surgery Unit, Villa Aurora Hospital, Foligno, ItalyOsteoarthritis (OA) is the most common chronic musculoskeletal disorder. It can affect any joint and is the most frequent single cause of disability in older adults.OA is a progressive degenerative disease involving the entire joint structure in a vicious circle that includes the capsule-bursa tissue inflammation, synovial fluid modifications, cartilage breakdown and erosions, osteochondral inflammatory damage leading to bone erosion and distortion.Research has identified the initial inflammatory-immunologic process that starts this vicious cycle leading to so-called early OA. Research has also identified the role played in the disease advancement by synoviocytes type A and B, chondrocytes, extracellular matrix, local immune-inflammatory mediators and proteases.This article investigates the joint-resident MSCs that play an essential local homeostatic role and regulate cell turn over and tissue repair. Resident MSCs establish and maintain a local regenerative microenvironment.The understanding of OA physiopathology clarifies the core mechanisms by which minimally invasive interventions might be able to halt and reverse the course of early stage OA. Interventions employing PRP, MSCs and exosomes are considered in this article.http://www.sciencedirect.com/science/article/pii/S2352320420300651Degenerative osteoarthritisMSCsEarly OATissue RegenerationPRP |
| spellingShingle | V. Di Nicola Degenerative osteoarthritis a reversible chronic disease Regenerative Therapy Degenerative osteoarthritis MSCs Early OA Tissue Regeneration PRP |
| title | Degenerative osteoarthritis a reversible chronic disease |
| title_full | Degenerative osteoarthritis a reversible chronic disease |
| title_fullStr | Degenerative osteoarthritis a reversible chronic disease |
| title_full_unstemmed | Degenerative osteoarthritis a reversible chronic disease |
| title_short | Degenerative osteoarthritis a reversible chronic disease |
| title_sort | degenerative osteoarthritis a reversible chronic disease |
| topic | Degenerative osteoarthritis MSCs Early OA Tissue Regeneration PRP |
| url | http://www.sciencedirect.com/science/article/pii/S2352320420300651 |
| work_keys_str_mv | AT vdinicola degenerativeosteoarthritisareversiblechronicdisease |