The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls
Recent evidence on the association between vitamin D and cognition in mentally healthy individuals is inconsistent. Furthermore, the link between vitamin D and cognitive ability in individuals with bipolar disorder has not been studied yet. Thus, we aimed to investigate the association between 25-hy...
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| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/19/4111 |
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| author | Bernadette Leser Nina Dalkner Adelina Tmava-Berisha Frederike T. Fellendorf Human-Friedrich Unterrainer Tatjana Stross Alexander Maget Martina Platzer Susanne A. Bengesser Alfred Häussl Ina Zwigl Armin Birner Robert Queissner Katharina Stix Linda Wels Elena M. D. Schönthaler Melanie Lenger Andreas R. Schwerdtfeger Sieglinde Zelzer Markus Herrmann Eva Z. Reininghaus |
| author_facet | Bernadette Leser Nina Dalkner Adelina Tmava-Berisha Frederike T. Fellendorf Human-Friedrich Unterrainer Tatjana Stross Alexander Maget Martina Platzer Susanne A. Bengesser Alfred Häussl Ina Zwigl Armin Birner Robert Queissner Katharina Stix Linda Wels Elena M. D. Schönthaler Melanie Lenger Andreas R. Schwerdtfeger Sieglinde Zelzer Markus Herrmann Eva Z. Reininghaus |
| author_sort | Bernadette Leser |
| collection | DOAJ |
| description | Recent evidence on the association between vitamin D and cognition in mentally healthy individuals is inconsistent. Furthermore, the link between vitamin D and cognitive ability in individuals with bipolar disorder has not been studied yet. Thus, we aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D), 24,25 dihydroxyvitamin D (24,25(OH)2D, the vitamin D metabolite ratio (VMR) and cognition in a cohort of euthymic patients with bipolar disorder. Vitamin D metabolites were measured simultaneously by liquid-chromatography tandem mass-spectrometry in serum samples from 86 outpatients with bipolar disorder and 93 healthy controls. Neither the inactive precursor 25(OH)D, nor the primary vitamin D catabolite 24,25(OH)2D, or the vitamin D metabolite ratio were significantly associated with the domains “attention”, “memory”, or “executive function” in individuals with bipolar disorder and healthy controls. Further, no vitamin D deficiency effect or interaction group × vitamin D deficiency was found in the cognitive domain scores. In summary, the present study does not support vitamin D metabolism as a modulating factor of cognitive function in euthymic BD patients. Considering the current study’s cross-sectional design, future research should expand these results in a longitudinal setting and include additional aspects of mental health, such as manic or depressive symptoms, long-term illness course and psychopharmacological treatment. |
| first_indexed | 2024-03-10T21:38:46Z |
| format | Article |
| id | doaj.art-7cbd61a6169446189f3280413e71130f |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T21:38:46Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-7cbd61a6169446189f3280413e71130f2023-11-19T14:50:20ZengMDPI AGNutrients2072-66432023-09-011519411110.3390/nu15194111The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy ControlsBernadette Leser0Nina Dalkner1Adelina Tmava-Berisha2Frederike T. Fellendorf3Human-Friedrich Unterrainer4Tatjana Stross5Alexander Maget6Martina Platzer7Susanne A. Bengesser8Alfred Häussl9Ina Zwigl10Armin Birner11Robert Queissner12Katharina Stix13Linda Wels14Elena M. D. Schönthaler15Melanie Lenger16Andreas R. Schwerdtfeger17Sieglinde Zelzer18Markus Herrmann19Eva Z. Reininghaus20Department of Psychology, University of Graz, 8010 Graz, AustriaDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, AustriaDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, AustriaDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, AustriaFaculty of Psychotherapy Science, Sigmund Freud University, 1020 Vienna, AustriaDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, AustriaDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, AustriaDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, AustriaDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, AustriaDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, AustriaDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, AustriaDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, AustriaDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, AustriaDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, AustriaDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, AustriaDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, AustriaDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, AustriaDepartment of Psychology, University of Graz, 8010 Graz, AustriaClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, AustriaClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, AustriaDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, AustriaRecent evidence on the association between vitamin D and cognition in mentally healthy individuals is inconsistent. Furthermore, the link between vitamin D and cognitive ability in individuals with bipolar disorder has not been studied yet. Thus, we aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D), 24,25 dihydroxyvitamin D (24,25(OH)2D, the vitamin D metabolite ratio (VMR) and cognition in a cohort of euthymic patients with bipolar disorder. Vitamin D metabolites were measured simultaneously by liquid-chromatography tandem mass-spectrometry in serum samples from 86 outpatients with bipolar disorder and 93 healthy controls. Neither the inactive precursor 25(OH)D, nor the primary vitamin D catabolite 24,25(OH)2D, or the vitamin D metabolite ratio were significantly associated with the domains “attention”, “memory”, or “executive function” in individuals with bipolar disorder and healthy controls. Further, no vitamin D deficiency effect or interaction group × vitamin D deficiency was found in the cognitive domain scores. In summary, the present study does not support vitamin D metabolism as a modulating factor of cognitive function in euthymic BD patients. Considering the current study’s cross-sectional design, future research should expand these results in a longitudinal setting and include additional aspects of mental health, such as manic or depressive symptoms, long-term illness course and psychopharmacological treatment.https://www.mdpi.com/2072-6643/15/19/4111bipolar disordervitamin Dfunctional vitamin D deficiency25(OH)D24,25(OH)2DVMR |
| spellingShingle | Bernadette Leser Nina Dalkner Adelina Tmava-Berisha Frederike T. Fellendorf Human-Friedrich Unterrainer Tatjana Stross Alexander Maget Martina Platzer Susanne A. Bengesser Alfred Häussl Ina Zwigl Armin Birner Robert Queissner Katharina Stix Linda Wels Elena M. D. Schönthaler Melanie Lenger Andreas R. Schwerdtfeger Sieglinde Zelzer Markus Herrmann Eva Z. Reininghaus The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls Nutrients bipolar disorder vitamin D functional vitamin D deficiency 25(OH)D 24,25(OH)2D VMR |
| title | The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls |
| title_full | The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls |
| title_fullStr | The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls |
| title_full_unstemmed | The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls |
| title_short | The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls |
| title_sort | influence of vitamin d status on cognitive ability in patients with bipolar disorder and healthy controls |
| topic | bipolar disorder vitamin D functional vitamin D deficiency 25(OH)D 24,25(OH)2D VMR |
| url | https://www.mdpi.com/2072-6643/15/19/4111 |
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