KR-31378, a Potassium-Channel Opener, Induces the Protection of Retinal Ganglion Cells in Rat Retinal Ischemic Models
KR-31378 is a newly developed KATP-channel opener. To investigate the ability of KR-31378 to protect retinal ganglion cells (RGC), experiments were conducted using two retinal ischemia models. Retinal ischemia was induced by transient high intraocular pressure (IOP) for acute ischemia and by three e...
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| Format: | Article |
| Language: | English |
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Elsevier
2009-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319312320 |
| _version_ | 1818030723822518272 |
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| author | Anho Choi Jun-Sub Choi Yone-Jung Yoon Kyung-A Kim Choun-Ki Joo |
| author_facet | Anho Choi Jun-Sub Choi Yone-Jung Yoon Kyung-A Kim Choun-Ki Joo |
| author_sort | Anho Choi |
| collection | DOAJ |
| description | KR-31378 is a newly developed KATP-channel opener. To investigate the ability of KR-31378 to protect retinal ganglion cells (RGC), experiments were conducted using two retinal ischemia models. Retinal ischemia was induced by transient high intraocular pressure (IOP) for acute ischemia and by three episcleral vein occlusion for chronic retinal ischemia. KR-31378 was injected intraperitoneally and administered orally in the acute and chronic ischemia models, respectively. Under the condition of chronic ischemia, RGC density in the KR-31378–treated group was statistically higher than that in the non-treated group, and IOP was reduced. In the acute retinal ischemia model, 90% of RGC were degenerated after one week in non-treated retina, but, RGC in KR-31378–treated retina were protected from ischemic damage in a dose-dependent manner and showed inhibited glial fibrillary acidic protein (GFAP) expression. Furthermore, the KR-31378 protective effect was inhibited by glibenclamide treatment in acute ischemia. These findings indicate that systemic KR-31378 treatment may protect against ischemic injury–induced ganglion cell loss in glaucoma. Keywords:: KR-31378, retinal ganglion cell, retinal ischemia, intraocular pressure, glaucoma |
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| format | Article |
| id | doaj.art-7cbe122b66c64cecb3a5b79fd8432906 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-10T05:40:07Z |
| publishDate | 2009-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-7cbe122b66c64cecb3a5b79fd84329062022-12-22T02:00:18ZengElsevierJournal of Pharmacological Sciences1347-86132009-01-011094511517KR-31378, a Potassium-Channel Opener, Induces the Protection of Retinal Ganglion Cells in Rat Retinal Ischemic ModelsAnho Choi0Jun-Sub Choi1Yone-Jung Yoon2Kyung-A Kim3Choun-Ki Joo4Department of Ophthalmology and Visual Science, College of Medicine and Korean Eye and Gene Bank Related to Blindness, The Catholic University of Korea, 505 Banpo-dong, Seocho-ku, Seoul 137-040, KoreaDepartment of Ophthalmology and Visual Science, College of Medicine and Korean Eye and Gene Bank Related to Blindness, The Catholic University of Korea, 505 Banpo-dong, Seocho-ku, Seoul 137-040, KoreaDepartment of Ophthalmology and Visual Science, College of Medicine and Korean Eye and Gene Bank Related to Blindness, The Catholic University of Korea, 505 Banpo-dong, Seocho-ku, Seoul 137-040, KoreaDepartment of Ophthalmology and Visual Science, College of Medicine and Korean Eye and Gene Bank Related to Blindness, The Catholic University of Korea, 505 Banpo-dong, Seocho-ku, Seoul 137-040, KoreaDepartment of Ophthalmology and Visual Science, College of Medicine and Korean Eye and Gene Bank Related to Blindness, The Catholic University of Korea, 505 Banpo-dong, Seocho-ku, Seoul 137-040, Korea; Corresponding author. ckjoo@catholic.ac.krKR-31378 is a newly developed KATP-channel opener. To investigate the ability of KR-31378 to protect retinal ganglion cells (RGC), experiments were conducted using two retinal ischemia models. Retinal ischemia was induced by transient high intraocular pressure (IOP) for acute ischemia and by three episcleral vein occlusion for chronic retinal ischemia. KR-31378 was injected intraperitoneally and administered orally in the acute and chronic ischemia models, respectively. Under the condition of chronic ischemia, RGC density in the KR-31378–treated group was statistically higher than that in the non-treated group, and IOP was reduced. In the acute retinal ischemia model, 90% of RGC were degenerated after one week in non-treated retina, but, RGC in KR-31378–treated retina were protected from ischemic damage in a dose-dependent manner and showed inhibited glial fibrillary acidic protein (GFAP) expression. Furthermore, the KR-31378 protective effect was inhibited by glibenclamide treatment in acute ischemia. These findings indicate that systemic KR-31378 treatment may protect against ischemic injury–induced ganglion cell loss in glaucoma. Keywords:: KR-31378, retinal ganglion cell, retinal ischemia, intraocular pressure, glaucomahttp://www.sciencedirect.com/science/article/pii/S1347861319312320 |
| spellingShingle | Anho Choi Jun-Sub Choi Yone-Jung Yoon Kyung-A Kim Choun-Ki Joo KR-31378, a Potassium-Channel Opener, Induces the Protection of Retinal Ganglion Cells in Rat Retinal Ischemic Models Journal of Pharmacological Sciences |
| title | KR-31378, a Potassium-Channel Opener, Induces the Protection of Retinal Ganglion Cells in Rat Retinal Ischemic Models |
| title_full | KR-31378, a Potassium-Channel Opener, Induces the Protection of Retinal Ganglion Cells in Rat Retinal Ischemic Models |
| title_fullStr | KR-31378, a Potassium-Channel Opener, Induces the Protection of Retinal Ganglion Cells in Rat Retinal Ischemic Models |
| title_full_unstemmed | KR-31378, a Potassium-Channel Opener, Induces the Protection of Retinal Ganglion Cells in Rat Retinal Ischemic Models |
| title_short | KR-31378, a Potassium-Channel Opener, Induces the Protection of Retinal Ganglion Cells in Rat Retinal Ischemic Models |
| title_sort | kr 31378 a potassium channel opener induces the protection of retinal ganglion cells in rat retinal ischemic models |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319312320 |
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