Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies

Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies

S-palmitoylation is an essential lipid modification catalysed by zDHHC-palmitoyl acyltransferases that regulates the localisation and activity of substrates in every class of protein and tissue investigated to date. In the heart, S-palmitoylation regulates sodium-calcium exchanger (NCX1) inactivatio...

Full description

Bibliographic Details
Main Authors:	Alice Main, Andri Boguslavskyi, Jacqueline Howie, Chien-Wen Kuo, Aileen Rankin, Francis L. Burton, Godfrey L. Smith, Roger Hajjar, George S. Baillie, Kenneth S. Campbell, Michael J. Shattock, William Fuller
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Series:	Frontiers in Physiology
Subjects:	palmitoylation hypertrophy heart failure ZDHHC5 cardiac muscle depalmitoylation
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2022.1023237/full

Similar Items

CellPalmSeq: A curated RNAseq database of palmitoylating and de-palmitoylating enzyme expression in human cell types and laboratory cell lines
by: Angela R. Wild, et al.
Published: (2023-01-01)

The role of s-palmitoylation in neurological diseases: implication for zDHHC family
by: Dan Liao, et al.
Published: (2024-01-01)

Substrate recruitment by zDHHC protein acyltransferases
by: Martin Ian P. Malgapo, et al.
Published: (2021-04-01)

ZDHHC20 mediated S-palmitoylation of fatty acid synthase (FASN) promotes hepatocarcinogenesis
by: Yaqi Mo, et al.
Published: (2024-12-01)

Research progress on S-palmitoylation modification mediated by the ZDHHC family in glioblastoma
by: Beiyan Tang, et al.
Published: (2024-11-01)

Aberrant palmitoylation caused by a ZDHHC21 mutation contributes to pathophysiology of Alzheimer’s disease
by: Wenwen Li, et al.
Published: (2023-06-01)

ZDHHC11 Suppresses Zika Virus Infections by Palmitoylating the Envelope Protein
by: Dingwen Hu, et al.
Published: (2023-01-01)

ZDHHC5-mediated S-palmitoylation of FAK promotes its membrane localization and epithelial-mesenchymal transition in glioma
by: Yang Wang, et al.
Published: (2024-01-01)

The ZDHHC13/ZDHHC17 subfamily: From biological functions to therapeutic targets of diseases
by: Ying Zhang, et al.
Published: (2024-11-01)

ZDHHC16 restrains osteogenic differentiation of bone marrow mesenchymal stem cells by inhibiting phosphorylation of CREB
by: Zhiwei Li, et al.
Published: (2023-01-01)

Editorial: Role of protein palmitoylation in synaptic plasticity and neuronal differentiation, volume II
by: Kevin P. Koster, et al.
Published: (2024-09-01)

Developmental NMDA receptor dysregulation in the infantile neuronal ceroid lipofuscinosis mouse model
by: Kevin P Koster, et al.
Published: (2019-04-01)

Expression of palmitoyl transferases in brain structures of mice genetically predisposed to depressive-like behavior
by: E. M. Kondaurova, et al.
Published: (2018-08-01)

Exploring the expression patterns of palmitoylating and de-palmitoylating enzymes in the mouse brain using the curated RNA-seq database BrainPalmSeq
by: Angela R Wild, et al.
Published: (2022-07-01)

The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment
by: Shaun S Sanders, et al.
Published: (2020-11-01)

A facile assay for zDHHC palmitoyl transferase activation elucidates effects of mutation and modification
by: Naoko Adachi, et al.
Published: (2025-02-01)

Targeted degradation of zDHHC-PATs decreases substrate S-palmitoylation.
by: Mingjie Bai, et al.
Published: (2024-01-01)

In vitro reconstitution of substrate S-acylation by the zDHHC family of protein acyltransferases
by: R. Elliot Murphy, et al.
Published: (2022-04-01)

Palmitoyltransferase ZDHHC6 promotes colon tumorigenesis by targeting PPARγ-driven lipid biosynthesis via regulating lipidome metabolic reprogramming
by: Junqi Shan, et al.
Published: (2024-08-01)

Palmitoylation: A Fatty Regulator of Myocardial Electrophysiology
by: Kobina Essandoh, et al.
Published: (2020-02-01)

Akap5 links synaptic dysfunction to neuroinflammatory signaling in a mouse model of infantile neuronal ceroid lipofuscinosis
by: Kevin P. Koster, et al.
Published: (2024-05-01)

Palmitoyltransferase ZDHHC3 Aggravates Nonalcoholic Steatohepatitis by Targeting S‐Palmitoylated IRHOM2
by: Minxuan Xu, et al.
Published: (2023-10-01)

Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade
by: Laurence Abrami, et al.
Published: (2017-08-01)

Fine‐mapping of ZDHHC2 identifies risk variants for schizophrenia in the Han Chinese population
by: Han Zhang, et al.
Published: (2020-07-01)

Ankyrin-B is lipid-modified by S-palmitoylation to promote dendritic membrane scaffolding of voltage-gated sodium channel NaV1.2 in neurons
by: Julie P. Gupta, et al.
Published: (2023-03-01)

RETRACTED ARTICLE: Palmitoyl transferases act as novel drug targets for pancreatic cancer
by: Zhiqing Lin, et al.
Published: (2023-04-01)

Selenoprotein K Increases Efficiency of DHHC6 Catalyzed Protein Palmitoylation by Stabilizing the Acyl-DHHC6 Intermediate
by: Gregory J. Fredericks, et al.
Published: (2017-12-01)

Propofol enhances stem-like properties of glioma via GABAAR‐dependent Src modulation of ZDHHC5-EZH2 palmitoylation mechanism
by: Xiaoqing Fan, et al.
Published: (2022-08-01)

Open Biology: overview for special issue on dynamics of protein fatty acylation
by: Marilyn D. Resh
Published: (2021-09-01)

<i>Trypanosoma brucei</i> Acyl-Protein Thioesterase-like (TbAPT-L) Is a Lipase with Esterase Activity for Short and Medium-Chain Fatty Acids but Has No Depalmitoylation Activity
by: Robert W. B. Brown, et al.
Published: (2022-10-01)

Palmitoylation of Metazoan Carotenoid Oxygenases
by: Sheetal Uppal, et al.
Published: (2020-04-01)

Decreased neuronal excitability in hypertriglyceridemia hamsters with acute seizures
by: Qiuyue Shen, et al.
Published: (2024-12-01)

Palmitoylation controls the stability of 190 kDa ankyrin-G in dendritic spines and is regulated by ZDHHC8 and lithium
by: Nicolas H. Piguel, et al.
Published: (2023-03-01)

Antioxidant and Anticancer Functions of Protein Acyltransferase DHHC3
by: Chandan Sharma, et al.
Published: (2022-05-01)

ZDHHC9: a promising therapeutic target for triple-negative breast cancer through immune modulation and immune checkpoint blockade resistance
by: Chao Xu, et al.
Published: (2023-10-01)

Maleimide scavenging enhances determination of protein S-palmitoylation state in acyl-exchange methods
by: Charlotte H. Hurst, et al.
Published: (2017-02-01)

Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases
by: Eleftheria Koropouli, et al.
Published: (2023-04-01)

Inhibition of ZDHHC16 promoted osteogenic differentiation and reduced ferroptosis of dental pulp stem cells by CREB
by: Wei Liu, et al.
Published: (2024-03-01)

Palmitoylation of synaptic proteins: roles in functional regulation and pathogenesis of neurodegenerative diseases
by: Jiaying Peng, et al.
Published: (2024-08-01)

S-palmitoylation of MAP kinase is essential for fungal virulence
by: Yuhang Duan, et al.
Published: (2024-12-01)