Metformin alleviates lung-endothelial hyperpermeability by regulating cofilin-1/PP2AC pathway

Metformin alleviates lung-endothelial hyperpermeability by regulating cofilin-1/PP2AC pathway

Background: Microvascular endothelial hyperpermeability is an earliest pathological hallmark in Acute Lung Injury (ALI), which progressively leads to Acute Respiratory Distress Syndrome (ARDS). Recently, vascular protective and anti-inflammatory effect of metformin, irrespective of glycemic control,...

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Bibliographic Details
Main Authors: M. Rizwan Siddiqui, Narsa M. Reddy, Hafeez M. Faridi, Mohd Shahid, Thomas P. Shanley
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Pharmacology
Subjects:
metformin
PP2A
cofilin-1
vascular endothelial cells
acute lung injury
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1211460/full

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