Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson’s Disease

Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson’s Disease

Parkinson’s disease (PD) is a chronic and progressive disorder characterized neuropathologically by loss of dopamine neurons in the substantia nigra, intracellular proteinaceous inclusions, reduction of dopaminergic terminals in the striatum, and increased neuroinflammatory cells. The consequent red...

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Bibliographic Details
Main Authors: Sudhakar R. Subramaniam, Howard J. Federoff
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
Parkinson’s disease
microglia
therapeutics
neuroinflammation
polarization
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2017.00176/full

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