Recent progress in metabolic reprogramming in gestational diabetes mellitus: a review
Gestational diabetes mellitus is a prevalent metabolic disease that can impact the normal course of pregnancy and delivery, leading to adverse outcomes for both mother and child. Its pathogenesis is complex and involves various factors, such as insulin resistance and β-cell dysfunction. Metabolic re...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1284160/full |
| _version_ | 1797367758411792384 |
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| author | Ya-ping Xie Shu Lin Shu Lin Bao-yuan Xie Hui-fen Zhao |
| author_facet | Ya-ping Xie Shu Lin Shu Lin Bao-yuan Xie Hui-fen Zhao |
| author_sort | Ya-ping Xie |
| collection | DOAJ |
| description | Gestational diabetes mellitus is a prevalent metabolic disease that can impact the normal course of pregnancy and delivery, leading to adverse outcomes for both mother and child. Its pathogenesis is complex and involves various factors, such as insulin resistance and β-cell dysfunction. Metabolic reprogramming, which involves mitochondrial oxidative phosphorylation and glycolysis, is crucial for maintaining human metabolic balance and is involved in the pathogenesis and progression of gestational diabetes mellitus. However, research on the link and metabolic pathways between metabolic reprogramming and gestational diabetes mellitus is limited. Therefore, we reviewed the relationship between metabolic reprogramming and gestational diabetes mellitus to provide new therapeutic strategies for maternal health during pregnancy and reduce the risk of developing gestational diabetes mellitus. |
| first_indexed | 2024-03-08T17:21:50Z |
| format | Article |
| id | doaj.art-7cc4055c18a44f019b6e27247daf290a |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T17:21:50Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-7cc4055c18a44f019b6e27247daf290a2024-01-03T04:32:06ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-01-011410.3389/fendo.2023.12841601284160Recent progress in metabolic reprogramming in gestational diabetes mellitus: a reviewYa-ping Xie0Shu Lin1Shu Lin2Bao-yuan Xie3Hui-fen Zhao4Nursing Department, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, ChinaCentre of Neurological and Metabolic Research, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, ChinaGroup of Neuroendocrinology, Garvan Institute of Medical Research, Sydney, NSW, AustraliaNursing Department, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, ChinaNursing Department, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, ChinaGestational diabetes mellitus is a prevalent metabolic disease that can impact the normal course of pregnancy and delivery, leading to adverse outcomes for both mother and child. Its pathogenesis is complex and involves various factors, such as insulin resistance and β-cell dysfunction. Metabolic reprogramming, which involves mitochondrial oxidative phosphorylation and glycolysis, is crucial for maintaining human metabolic balance and is involved in the pathogenesis and progression of gestational diabetes mellitus. However, research on the link and metabolic pathways between metabolic reprogramming and gestational diabetes mellitus is limited. Therefore, we reviewed the relationship between metabolic reprogramming and gestational diabetes mellitus to provide new therapeutic strategies for maternal health during pregnancy and reduce the risk of developing gestational diabetes mellitus.https://www.frontiersin.org/articles/10.3389/fendo.2023.1284160/fullblood glucosegestational diabetes mellitusmetabolic reprogrammingpathophysiologymitochondrial oxidative phosphorylation |
| spellingShingle | Ya-ping Xie Shu Lin Shu Lin Bao-yuan Xie Hui-fen Zhao Recent progress in metabolic reprogramming in gestational diabetes mellitus: a review Frontiers in Endocrinology blood glucose gestational diabetes mellitus metabolic reprogramming pathophysiology mitochondrial oxidative phosphorylation |
| title | Recent progress in metabolic reprogramming in gestational diabetes mellitus: a review |
| title_full | Recent progress in metabolic reprogramming in gestational diabetes mellitus: a review |
| title_fullStr | Recent progress in metabolic reprogramming in gestational diabetes mellitus: a review |
| title_full_unstemmed | Recent progress in metabolic reprogramming in gestational diabetes mellitus: a review |
| title_short | Recent progress in metabolic reprogramming in gestational diabetes mellitus: a review |
| title_sort | recent progress in metabolic reprogramming in gestational diabetes mellitus a review |
| topic | blood glucose gestational diabetes mellitus metabolic reprogramming pathophysiology mitochondrial oxidative phosphorylation |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1284160/full |
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