Changes in the blood fatty-acid profile associated with oxidative-antioxidant disturbances in coronary atherosclerosis
Background: The objective of this work was to study the profile of fatty acids and to search for associations of fatty acids with oxidative-antioxidant parameters and an oxidative-inflammatory biomarker (lipoprotein-associated phospholipase A2) in men with coronary atherosclerosis and coronary heart...
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| Format: | Article |
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Society of Medical Biochemists of Serbia, Belgrade
2020-01-01
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| Series: | Journal of Medical Biochemistry |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2020/1452-82582001046R.pdf |
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| author | Ragino Yuliya I. Shramko Viktoriya S. Stakhneva Ekaterina M. Chernyak Elena I. Morozov Sergey V. Shakhtshneider Elena V. Polonskaya Yana V. Shcherbakova Liliia V. Chernyavskiy Alexander M. |
| author_facet | Ragino Yuliya I. Shramko Viktoriya S. Stakhneva Ekaterina M. Chernyak Elena I. Morozov Sergey V. Shakhtshneider Elena V. Polonskaya Yana V. Shcherbakova Liliia V. Chernyavskiy Alexander M. |
| author_sort | Ragino Yuliya I. |
| collection | DOAJ |
| description | Background: The objective of this work was to study the profile of fatty acids and to search for associations of fatty acids with oxidative-antioxidant parameters and an oxidative-inflammatory biomarker (lipoprotein-associated phospholipase A2) in men with coronary atherosclerosis and coronary heart disease. Methods: Analysis of 20 fatty acids was performed in 60 men with angiographically confirmed coronary atherosclerosis and coronary heart disease and in a control group of men without coronary heart disease. Serum fatty-acid content was evaluated by high-performance gas-liquid chromatography. The blood levels of oxidative stress, total antioxidative defence, and lipoprotein-associated phospholipase 2 were analyzed. Results: In the group of men with coronary atherosclerosis the levels of myristic and palmitic fatty acids were higher by 59% and 22%, respectively. An increase in the weight percentage of monounsaturated fatty acids was noted, such as palmitoleic, oleic, and octadecenic. Significantly lower levels of polyunsaturated fatty acids, such as linolic, eicosadienoic, eicosatrienoic, arachidonic, eicosapentaenoic, glinolenic, docosapentaenoic, and docosahexaenoic were detected in the group with coronary atherosclerosis. The lipoprotein-associated phospholipase A2 level was higher by 48%. Oxidative stress was higher by 17%, and the total antioxidant defence in serum was lower by 45%. We found correlations between fatty acids and oxidative-antioxidative alterations. The relative risk of vulnerable atherosclerotic plaques correlated with increased levels of palmitic, stearic, oleic, and linolic fatty acids. Conclusions: Significant alterations in the profile of fatty acids are associated with oxidative-antioxidative alterations and are accompanied by an increase in free-radical formation, which can probably serve as a risk factor of atherosclerosis. |
| first_indexed | 2024-12-11T20:46:44Z |
| format | Article |
| id | doaj.art-7cc82f2db68c4e9cb5947229c710fca8 |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-12-11T20:46:44Z |
| publishDate | 2020-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
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| series | Journal of Medical Biochemistry |
| spelling | doaj.art-7cc82f2db68c4e9cb5947229c710fca82022-12-22T00:51:21ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662020-01-0139146531452-82582001046RChanges in the blood fatty-acid profile associated with oxidative-antioxidant disturbances in coronary atherosclerosisRagino Yuliya I.0Shramko Viktoriya S.1Stakhneva Ekaterina M.2Chernyak Elena I.3Morozov Sergey V.4Shakhtshneider Elena V.5Polonskaya Yana V.6Shcherbakova Liliia V.7Chernyavskiy Alexander M.8Siberian Branch of Russian Academy of Sciences (IIPM - Branch of IC&G SB RAS), Institute of Internal and Preventive Medicine (branch of Institute of Cytology and Genetics), Novosibirsk, RussiaSiberian Branch of Russian Academy of Sciences (IIPM - Branch of IC&G SB RAS), Institute of Internal and Preventive Medicine (branch of Institute of Cytology and Genetics), Novosibirsk, RussiaSiberian Branch of Russian Academy of Sciences (IIPM - Branch of IC&G SB RAS), Institute of Internal and Preventive Medicine (branch of Institute of Cytology and Genetics), Novosibirsk, RussiaN. N. Vorozhtsov Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences (NIOCH SB RAS), Novosibirsk, RussiaN. N. Vorozhtsov Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences (NIOCH SB RAS), Novosibirsk, RussiaSiberian Branch of Russian Academy of Sciences (IIPM - Branch of IC&G SB RAS), Institute of Internal and Preventive Medicine (branch of Institute of Cytology and Genetics), Novosibirsk, Russia + Novosibirsk State University, Novosibirsk, RussiaSiberian Branch of Russian Academy of Sciences (IIPM - Branch of IC&G SB RAS), Institute of Internal and Preventive Medicine (branch of Institute of Cytology and Genetics), Novosibirsk, RussiaSiberian Branch of Russian Academy of Sciences (IIPM - Branch of IC&G SB RAS), Institute of Internal and Preventive Medicine (branch of Institute of Cytology and Genetics), Novosibirsk, RussiaFederal Publicly Funded Institution Meshalkin National Medical Research Center of the Ministry of Health of the Russian Federation, Novosibirsk, RussiaBackground: The objective of this work was to study the profile of fatty acids and to search for associations of fatty acids with oxidative-antioxidant parameters and an oxidative-inflammatory biomarker (lipoprotein-associated phospholipase A2) in men with coronary atherosclerosis and coronary heart disease. Methods: Analysis of 20 fatty acids was performed in 60 men with angiographically confirmed coronary atherosclerosis and coronary heart disease and in a control group of men without coronary heart disease. Serum fatty-acid content was evaluated by high-performance gas-liquid chromatography. The blood levels of oxidative stress, total antioxidative defence, and lipoprotein-associated phospholipase 2 were analyzed. Results: In the group of men with coronary atherosclerosis the levels of myristic and palmitic fatty acids were higher by 59% and 22%, respectively. An increase in the weight percentage of monounsaturated fatty acids was noted, such as palmitoleic, oleic, and octadecenic. Significantly lower levels of polyunsaturated fatty acids, such as linolic, eicosadienoic, eicosatrienoic, arachidonic, eicosapentaenoic, glinolenic, docosapentaenoic, and docosahexaenoic were detected in the group with coronary atherosclerosis. The lipoprotein-associated phospholipase A2 level was higher by 48%. Oxidative stress was higher by 17%, and the total antioxidant defence in serum was lower by 45%. We found correlations between fatty acids and oxidative-antioxidative alterations. The relative risk of vulnerable atherosclerotic plaques correlated with increased levels of palmitic, stearic, oleic, and linolic fatty acids. Conclusions: Significant alterations in the profile of fatty acids are associated with oxidative-antioxidative alterations and are accompanied by an increase in free-radical formation, which can probably serve as a risk factor of atherosclerosis.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2020/1452-82582001046R.pdfatherosclerosisatherosclerotic plaquefatty acidlipidlipoprotein-associated phospholipase 2oxidative stress |
| spellingShingle | Ragino Yuliya I. Shramko Viktoriya S. Stakhneva Ekaterina M. Chernyak Elena I. Morozov Sergey V. Shakhtshneider Elena V. Polonskaya Yana V. Shcherbakova Liliia V. Chernyavskiy Alexander M. Changes in the blood fatty-acid profile associated with oxidative-antioxidant disturbances in coronary atherosclerosis Journal of Medical Biochemistry atherosclerosis atherosclerotic plaque fatty acid lipid lipoprotein-associated phospholipase 2 oxidative stress |
| title | Changes in the blood fatty-acid profile associated with oxidative-antioxidant disturbances in coronary atherosclerosis |
| title_full | Changes in the blood fatty-acid profile associated with oxidative-antioxidant disturbances in coronary atherosclerosis |
| title_fullStr | Changes in the blood fatty-acid profile associated with oxidative-antioxidant disturbances in coronary atherosclerosis |
| title_full_unstemmed | Changes in the blood fatty-acid profile associated with oxidative-antioxidant disturbances in coronary atherosclerosis |
| title_short | Changes in the blood fatty-acid profile associated with oxidative-antioxidant disturbances in coronary atherosclerosis |
| title_sort | changes in the blood fatty acid profile associated with oxidative antioxidant disturbances in coronary atherosclerosis |
| topic | atherosclerosis atherosclerotic plaque fatty acid lipid lipoprotein-associated phospholipase 2 oxidative stress |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2020/1452-82582001046R.pdf |
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