Evaluating transcranial magnetic stimulation (TMS) induced electric fields in pediatric stroke
Transcranial magnetic stimulation (TMS) is an increasingly popular tool for stroke rehabilitation. Consequently, researchers have started to explore the use of TMS in pediatric stroke. However, the application of TMS in a developing brain with pathologies comes with a unique set of challenges. The e...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158221000073 |
| _version_ | 1818916369914134528 |
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| author | Kathleen E. Mantell Ellen N. Sutter Sina Shirinpour Samuel T. Nemanich Daniel H. Lench Bernadette T. Gillick Alexander Opitz |
| author_facet | Kathleen E. Mantell Ellen N. Sutter Sina Shirinpour Samuel T. Nemanich Daniel H. Lench Bernadette T. Gillick Alexander Opitz |
| author_sort | Kathleen E. Mantell |
| collection | DOAJ |
| description | Transcranial magnetic stimulation (TMS) is an increasingly popular tool for stroke rehabilitation. Consequently, researchers have started to explore the use of TMS in pediatric stroke. However, the application of TMS in a developing brain with pathologies comes with a unique set of challenges. The effect of TMS-induced electric fields has not been explored in children with stroke lesions. Here, we used finite element method (FEM) modeling to study how the electric field strength is affected by the presence of a lesion. We created individual realistic head models from MRIs (n = 6) of children with unilateral cerebral palsy due to perinatal stroke. We conducted TMS electric field simulations for coil locations over lesioned and non-lesioned hemispheres. We found that the presence of a lesion can strongly affect the electric field distribution. On the group level, the mean electric field strength did not differ between lesioned and non-lesioned hemispheres but exhibited a greater variability in the lesioned hemisphere. Other factors such as coil-to-cortex distance have a strong influence on the TMS electric field even in the presence of lesions. Our study has important implications for the delivery of TMS in children with brain lesions with respect to TMS dosing and coil placement. |
| first_indexed | 2024-12-20T00:17:05Z |
| format | Article |
| id | doaj.art-7cc8d380e864439bb0cc75cd360c20ce |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-20T00:17:05Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-7cc8d380e864439bb0cc75cd360c20ce2022-12-21T20:00:19ZengElsevierNeuroImage: Clinical2213-15822021-01-0129102563Evaluating transcranial magnetic stimulation (TMS) induced electric fields in pediatric strokeKathleen E. Mantell0Ellen N. Sutter1Sina Shirinpour2Samuel T. Nemanich3Daniel H. Lench4Bernadette T. Gillick5Alexander Opitz6Department of Biomedical Engineering, University of Minnesota, Minneapolis, USADepartment of Rehabilitation Medicine, University of Minnesota, Minneapolis, USADepartment of Biomedical Engineering, University of Minnesota, Minneapolis, USADepartment of Rehabilitation Medicine, University of Minnesota, Minneapolis, USADepartment of Rehabilitation Medicine, University of Minnesota, Minneapolis, USADepartment of Rehabilitation Medicine, University of Minnesota, Minneapolis, USADepartment of Biomedical Engineering, University of Minnesota, Minneapolis, USA; Corresponding author.Transcranial magnetic stimulation (TMS) is an increasingly popular tool for stroke rehabilitation. Consequently, researchers have started to explore the use of TMS in pediatric stroke. However, the application of TMS in a developing brain with pathologies comes with a unique set of challenges. The effect of TMS-induced electric fields has not been explored in children with stroke lesions. Here, we used finite element method (FEM) modeling to study how the electric field strength is affected by the presence of a lesion. We created individual realistic head models from MRIs (n = 6) of children with unilateral cerebral palsy due to perinatal stroke. We conducted TMS electric field simulations for coil locations over lesioned and non-lesioned hemispheres. We found that the presence of a lesion can strongly affect the electric field distribution. On the group level, the mean electric field strength did not differ between lesioned and non-lesioned hemispheres but exhibited a greater variability in the lesioned hemisphere. Other factors such as coil-to-cortex distance have a strong influence on the TMS electric field even in the presence of lesions. Our study has important implications for the delivery of TMS in children with brain lesions with respect to TMS dosing and coil placement.http://www.sciencedirect.com/science/article/pii/S2213158221000073 |
| spellingShingle | Kathleen E. Mantell Ellen N. Sutter Sina Shirinpour Samuel T. Nemanich Daniel H. Lench Bernadette T. Gillick Alexander Opitz Evaluating transcranial magnetic stimulation (TMS) induced electric fields in pediatric stroke NeuroImage: Clinical |
| title | Evaluating transcranial magnetic stimulation (TMS) induced electric fields in pediatric stroke |
| title_full | Evaluating transcranial magnetic stimulation (TMS) induced electric fields in pediatric stroke |
| title_fullStr | Evaluating transcranial magnetic stimulation (TMS) induced electric fields in pediatric stroke |
| title_full_unstemmed | Evaluating transcranial magnetic stimulation (TMS) induced electric fields in pediatric stroke |
| title_short | Evaluating transcranial magnetic stimulation (TMS) induced electric fields in pediatric stroke |
| title_sort | evaluating transcranial magnetic stimulation tms induced electric fields in pediatric stroke |
| url | http://www.sciencedirect.com/science/article/pii/S2213158221000073 |
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