Efficacy of Potassium Citrate in Treatment of Nephrolithiasis Less Than 7mm Diameter in Children without Any Metabolic or Infectious Risk Factors
Background and purpose: Nephrolithiasis in the pediatric population includes 7% of all kidney stone disorders in all age groups. Potassium citrate is one of medical agents used in treatment of these disorders. This study investigated the role of potassium citrate in treatment of patients with kidney...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2017-09-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
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| Online Access: | http://jmums.mazums.ac.ir/article-1-8484-en.html |
| _version_ | 1828054798520287232 |
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| author | Hamid Mohammadjafari Mehrnoush Kosaryan Zahra Tahernassab |
| author_facet | Hamid Mohammadjafari Mehrnoush Kosaryan Zahra Tahernassab |
| author_sort | Hamid Mohammadjafari |
| collection | DOAJ |
| description | Background and purpose: Nephrolithiasis in the pediatric population includes 7% of all kidney stone disorders in all age groups. Potassium citrate is one of medical agents used in treatment of these disorders. This study investigated the role of potassium citrate in treatment of patients with kidney stones without any metabolic or infectious risk factors.
Materials and methods: A clinical trial was conducted in all patients less than 16 years of age in whom ultrasonography confirmed kidney or urinary tract stones <7mm but had no metabolic or infectious risk factors. Patients were divided into two groups; group I (n=47) were treated with 1-2ml/kg potassium citrate daily and group II (n=33) who received no medication.
Results: A total of 149 patients with nephrolithiasis was assessed of whom 80 included in current study. Improvements in number of stones was seen in 29 (76%) patients in group I and 17 (57%) in group II (P=0.403). Improvements in maximum size of stones were found in 30 (79%) cases in group I and 22 (73%) patients in group II (P=0.791). Total burden of stones showed improvements in 82% of patients in group I and 73% of those in group II (P=0.887). There were no significant differences between the two groups in any of these items.
Conclusion: Potassium citrate can reduce the size and number of stones in most children with renal stones less than 7mm who have no underlying risk factor. But current study found non-pharmacological supportive treatments to yield similar results. |
| first_indexed | 2024-04-10T20:28:39Z |
| format | Article |
| id | doaj.art-7cc933301dfd43bf8032dacc171cdd4d |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T20:28:39Z |
| publishDate | 2017-09-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-7cc933301dfd43bf8032dacc171cdd4d2023-01-25T07:52:00ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792017-09-01271524049Efficacy of Potassium Citrate in Treatment of Nephrolithiasis Less Than 7mm Diameter in Children without Any Metabolic or Infectious Risk FactorsHamid Mohammadjafari0Mehrnoush Kosaryan1Zahra Tahernassab2 Professor, Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran Professor, Thalassemia Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari Iran Faculty of Medicine, Mazandaran University of Medical Sciences, Sari Iran Background and purpose: Nephrolithiasis in the pediatric population includes 7% of all kidney stone disorders in all age groups. Potassium citrate is one of medical agents used in treatment of these disorders. This study investigated the role of potassium citrate in treatment of patients with kidney stones without any metabolic or infectious risk factors. Materials and methods: A clinical trial was conducted in all patients less than 16 years of age in whom ultrasonography confirmed kidney or urinary tract stones <7mm but had no metabolic or infectious risk factors. Patients were divided into two groups; group I (n=47) were treated with 1-2ml/kg potassium citrate daily and group II (n=33) who received no medication. Results: A total of 149 patients with nephrolithiasis was assessed of whom 80 included in current study. Improvements in number of stones was seen in 29 (76%) patients in group I and 17 (57%) in group II (P=0.403). Improvements in maximum size of stones were found in 30 (79%) cases in group I and 22 (73%) patients in group II (P=0.791). Total burden of stones showed improvements in 82% of patients in group I and 73% of those in group II (P=0.887). There were no significant differences between the two groups in any of these items. Conclusion: Potassium citrate can reduce the size and number of stones in most children with renal stones less than 7mm who have no underlying risk factor. But current study found non-pharmacological supportive treatments to yield similar results.http://jmums.mazums.ac.ir/article-1-8484-en.htmlnephrolithiasispotassium citratepolycitrate |
| spellingShingle | Hamid Mohammadjafari Mehrnoush Kosaryan Zahra Tahernassab Efficacy of Potassium Citrate in Treatment of Nephrolithiasis Less Than 7mm Diameter in Children without Any Metabolic or Infectious Risk Factors Journal of Mazandaran University of Medical Sciences nephrolithiasis potassium citrate polycitrate |
| title | Efficacy of Potassium Citrate in Treatment of Nephrolithiasis Less Than 7mm Diameter in Children without Any Metabolic
or Infectious Risk Factors |
| title_full | Efficacy of Potassium Citrate in Treatment of Nephrolithiasis Less Than 7mm Diameter in Children without Any Metabolic
or Infectious Risk Factors |
| title_fullStr | Efficacy of Potassium Citrate in Treatment of Nephrolithiasis Less Than 7mm Diameter in Children without Any Metabolic
or Infectious Risk Factors |
| title_full_unstemmed | Efficacy of Potassium Citrate in Treatment of Nephrolithiasis Less Than 7mm Diameter in Children without Any Metabolic
or Infectious Risk Factors |
| title_short | Efficacy of Potassium Citrate in Treatment of Nephrolithiasis Less Than 7mm Diameter in Children without Any Metabolic
or Infectious Risk Factors |
| title_sort | efficacy of potassium citrate in treatment of nephrolithiasis less than 7mm diameter in children without any metabolic or infectious risk factors |
| topic | nephrolithiasis potassium citrate polycitrate |
| url | http://jmums.mazums.ac.ir/article-1-8484-en.html |
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