Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review
Cardiovascular diseases (CVD), with high morbidity and mortality, seriously affect people’s life and social development. Clinically, reperfusion therapy is typically used to treat ischemic cardiomyopathy, such as severe coronary heart disease and acute myocardial infarction. However, reperfusion the...
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| Format: | Article |
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PeerJ Inc.
2023-03-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/14952.pdf |
| _version_ | 1797417586742263808 |
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| author | Cuihua Liu Zunjiang Li Botao Li Wei Liu Shizhong Zhang Kuncheng Qiu Wei Zhu |
| author_facet | Cuihua Liu Zunjiang Li Botao Li Wei Liu Shizhong Zhang Kuncheng Qiu Wei Zhu |
| author_sort | Cuihua Liu |
| collection | DOAJ |
| description | Cardiovascular diseases (CVD), with high morbidity and mortality, seriously affect people’s life and social development. Clinically, reperfusion therapy is typically used to treat ischemic cardiomyopathy, such as severe coronary heart disease and acute myocardial infarction. However, reperfusion therapy can lead to myocardial ischemia reperfusion injury (MIRI), which can affect the prognosis of patients. Studying the mechanisms of MIRI can help us improve the treatment of MIRI. The pathological process of MIRI involves many mechanisms such as ferroptosis and mitophagy. Ferroptosis can exacerbate MIRI, and regulation of mitophagy can alleviate MIRI. Both ferroptosis and mitophagy are closely related to ROS, but there is no clear understanding of the relationship between ferroptosis and mitophagy. In this review, we analyzed the relationship between ferroptosis and mitophagy according to the role of mTOR, NLPR3 and HIF. In addition, simultaneous regulation of mitophagy and ferroptosis may be superior to single therapy for MIRI. We summarized potential drugs that can regulate mitophagy and/or ferroptosis, hoping to provide reference for the development of drugs and methods for MIRI treatment. |
| first_indexed | 2024-03-09T06:21:56Z |
| format | Article |
| id | doaj.art-7cc9f6590010451798e842c19f766e56 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:21:56Z |
| publishDate | 2023-03-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-7cc9f6590010451798e842c19f766e562023-12-03T11:38:20ZengPeerJ Inc.PeerJ2167-83592023-03-0111e1495210.7717/peerj.14952Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-reviewCuihua Liu0Zunjiang Li1Botao Li2Wei Liu3Shizhong Zhang4Kuncheng Qiu5Wei Zhu6Third-Grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, Medical College, China Three Gorges University, Yichang, Hubei Province, ChinaThe Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, ChinaThird-Grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, Medical College, China Three Gorges University, Yichang, Hubei Province, ChinaThird-Grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, Medical College, China Three Gorges University, Yichang, Hubei Province, ChinaThird-Grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, Medical College, China Three Gorges University, Yichang, Hubei Province, ChinaThird-Grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, Medical College, China Three Gorges University, Yichang, Hubei Province, ChinaThe Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, ChinaCardiovascular diseases (CVD), with high morbidity and mortality, seriously affect people’s life and social development. Clinically, reperfusion therapy is typically used to treat ischemic cardiomyopathy, such as severe coronary heart disease and acute myocardial infarction. However, reperfusion therapy can lead to myocardial ischemia reperfusion injury (MIRI), which can affect the prognosis of patients. Studying the mechanisms of MIRI can help us improve the treatment of MIRI. The pathological process of MIRI involves many mechanisms such as ferroptosis and mitophagy. Ferroptosis can exacerbate MIRI, and regulation of mitophagy can alleviate MIRI. Both ferroptosis and mitophagy are closely related to ROS, but there is no clear understanding of the relationship between ferroptosis and mitophagy. In this review, we analyzed the relationship between ferroptosis and mitophagy according to the role of mTOR, NLPR3 and HIF. In addition, simultaneous regulation of mitophagy and ferroptosis may be superior to single therapy for MIRI. We summarized potential drugs that can regulate mitophagy and/or ferroptosis, hoping to provide reference for the development of drugs and methods for MIRI treatment.https://peerj.com/articles/14952.pdfFerroptosisMitophagyRelationshipMyocardial ischemia reperfusion injuryMechanism |
| spellingShingle | Cuihua Liu Zunjiang Li Botao Li Wei Liu Shizhong Zhang Kuncheng Qiu Wei Zhu Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review PeerJ Ferroptosis Mitophagy Relationship Myocardial ischemia reperfusion injury Mechanism |
| title | Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review |
| title_full | Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review |
| title_fullStr | Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review |
| title_full_unstemmed | Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review |
| title_short | Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review |
| title_sort | relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury a mini review |
| topic | Ferroptosis Mitophagy Relationship Myocardial ischemia reperfusion injury Mechanism |
| url | https://peerj.com/articles/14952.pdf |
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