Medicinal plants with potential neuroprotective activity studied in transgenic strains of Caenorhabditis elegans. Systematic review 2010-2021
Context: Treatments for neurodegenerative diseases generate multiple adverse effects and do not reverse the progressive damage of the disease. It is a priority to find alternatives from medicinal plants as a source of molecules with neuroprotective potential. Caenorhabditis elegans as an in vivo scr...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
GarVal Editorial Ltda.
2022-09-01
|
| Series: | Journal of Pharmacy & Pharmacognosy Research |
| Subjects: | |
| Online Access: | https://jppres.com/jppres/pdf/vol10/jppres22.1379_10.5.812.pdf |
| _version_ | 1828237837740277760 |
|---|---|
| author | Yenny Y. Lozano Sara E. Giraldo Harold S. Castro Ruth M. Sánchez |
| author_facet | Yenny Y. Lozano Sara E. Giraldo Harold S. Castro Ruth M. Sánchez |
| author_sort | Yenny Y. Lozano |
| collection | DOAJ |
| description | Context: Treatments for neurodegenerative diseases generate multiple adverse effects and do not reverse the progressive damage of the disease. It is a priority to find alternatives from medicinal plants as a source of molecules with neuroprotective potential. Caenorhabditis elegans as an in vivo screening model allows evaluating and selecting molecules with neuroprotective activity.
Aims: To carry out a systematic review between the years 2010-2021, on traditionally used plant resources with potential neuroprotective activity evaluated in C. elegans.
Methods: The review was carried out in 4 stages according to the PRISMA methodology. 1. Research question approach and objectives to define the thematic axes and create the search algorithm. 2. Search of ScienceDirect, Scopus, PubMed, Web of Science, Ebsco, Taylor and Francis and Scielo databases, 3. Selection of articles according to inclusion and exclusion criteria. 4. Organization of information relevant to the review.
Results: The search yielded 122 articles, defining 12 base articles for the construction of the review. The extracts in dichloromethane, butanol, ethanolic and aqueous stand out; as well as iridoid and flavonoid type biocompounds. Antioxidant activity was the most cited. Among the neuroprotective effects in C. elegans transgenic strains, the increase in the percentage of survival of nematodes, reduction of paralysis, inhibition of protein aggregation and regulation of genes associated with stress stand out.
Conclusions: The identification of bioactive molecules and extracts obtained from medicinal plants of traditional use with neuroprotective potential, is favored by the use of C. elegans as a model for the study of neurodegenerative diseases. |
| first_indexed | 2024-04-12T20:54:47Z |
| format | Article |
| id | doaj.art-7cca85597ae74c499d00e572cbea3911 |
| institution | Directory Open Access Journal |
| issn | 0719-4250 |
| language | English |
| last_indexed | 2024-04-12T20:54:47Z |
| publishDate | 2022-09-01 |
| publisher | GarVal Editorial Ltda. |
| record_format | Article |
| series | Journal of Pharmacy & Pharmacognosy Research |
| spelling | doaj.art-7cca85597ae74c499d00e572cbea39112022-12-22T03:17:01ZengGarVal Editorial Ltda.Journal of Pharmacy & Pharmacognosy Research0719-42502022-09-01105812836https://doi.org/10.56499/jppres22.1379_10.5.812Medicinal plants with potential neuroprotective activity studied in transgenic strains of Caenorhabditis elegans. Systematic review 2010-2021Yenny Y. Lozano0Sara E. Giraldo1Harold S. Castro2Ruth M. Sánchez 3Universidad de La Salle, Bogotá, D.C., ColombiaUniversidad de La Salle, Bogotá, D.C., ColombiaUniversidad de La Salle, Bogotá, D.C., ColombiaUniversidad Colegio Mayor de Cundinamarca, Bogotá, D.C., ColombiaContext: Treatments for neurodegenerative diseases generate multiple adverse effects and do not reverse the progressive damage of the disease. It is a priority to find alternatives from medicinal plants as a source of molecules with neuroprotective potential. Caenorhabditis elegans as an in vivo screening model allows evaluating and selecting molecules with neuroprotective activity. Aims: To carry out a systematic review between the years 2010-2021, on traditionally used plant resources with potential neuroprotective activity evaluated in C. elegans. Methods: The review was carried out in 4 stages according to the PRISMA methodology. 1. Research question approach and objectives to define the thematic axes and create the search algorithm. 2. Search of ScienceDirect, Scopus, PubMed, Web of Science, Ebsco, Taylor and Francis and Scielo databases, 3. Selection of articles according to inclusion and exclusion criteria. 4. Organization of information relevant to the review. Results: The search yielded 122 articles, defining 12 base articles for the construction of the review. The extracts in dichloromethane, butanol, ethanolic and aqueous stand out; as well as iridoid and flavonoid type biocompounds. Antioxidant activity was the most cited. Among the neuroprotective effects in C. elegans transgenic strains, the increase in the percentage of survival of nematodes, reduction of paralysis, inhibition of protein aggregation and regulation of genes associated with stress stand out. Conclusions: The identification of bioactive molecules and extracts obtained from medicinal plants of traditional use with neuroprotective potential, is favored by the use of C. elegans as a model for the study of neurodegenerative diseases.https://jppres.com/jppres/pdf/vol10/jppres22.1379_10.5.812.pdfcaenorhadbitis elegansalzheimer’s diseaseparkinson’s diseasehuntington’s diseaseneuroprotectionmedicinal plants |
| spellingShingle | Yenny Y. Lozano Sara E. Giraldo Harold S. Castro Ruth M. Sánchez Medicinal plants with potential neuroprotective activity studied in transgenic strains of Caenorhabditis elegans. Systematic review 2010-2021 Journal of Pharmacy & Pharmacognosy Research caenorhadbitis elegans alzheimer’s disease parkinson’s disease huntington’s disease neuroprotection medicinal plants |
| title | Medicinal plants with potential neuroprotective activity studied in transgenic strains of Caenorhabditis elegans. Systematic review 2010-2021 |
| title_full | Medicinal plants with potential neuroprotective activity studied in transgenic strains of Caenorhabditis elegans. Systematic review 2010-2021 |
| title_fullStr | Medicinal plants with potential neuroprotective activity studied in transgenic strains of Caenorhabditis elegans. Systematic review 2010-2021 |
| title_full_unstemmed | Medicinal plants with potential neuroprotective activity studied in transgenic strains of Caenorhabditis elegans. Systematic review 2010-2021 |
| title_short | Medicinal plants with potential neuroprotective activity studied in transgenic strains of Caenorhabditis elegans. Systematic review 2010-2021 |
| title_sort | medicinal plants with potential neuroprotective activity studied in transgenic strains of caenorhabditis elegans systematic review 2010 2021 |
| topic | caenorhadbitis elegans alzheimer’s disease parkinson’s disease huntington’s disease neuroprotection medicinal plants |
| url | https://jppres.com/jppres/pdf/vol10/jppres22.1379_10.5.812.pdf |
| work_keys_str_mv | AT yennyylozano medicinalplantswithpotentialneuroprotectiveactivitystudiedintransgenicstrainsofcaenorhabditiseleganssystematicreview20102021 AT saraegiraldo medicinalplantswithpotentialneuroprotectiveactivitystudiedintransgenicstrainsofcaenorhabditiseleganssystematicreview20102021 AT haroldscastro medicinalplantswithpotentialneuroprotectiveactivitystudiedintransgenicstrainsofcaenorhabditiseleganssystematicreview20102021 AT ruthmsanchez medicinalplantswithpotentialneuroprotectiveactivitystudiedintransgenicstrainsofcaenorhabditiseleganssystematicreview20102021 |