Neuromodulation as a new avenue for resuscitation in hemorrhagic shock
Abstract Hemorrhagic shock (HS), a major cause of early death from trauma, accounts for around 40% of mortality, with 33–56% of these deaths occurring before the patient reaches a medical facility. Intravenous fluid therapy and blood transfusions are the cornerstone of treating HS. However, these op...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-10-01
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| Series: | Bioelectronic Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s42234-019-0033-z |
| _version_ | 1819121015064625152 |
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| author | Keren Powell Kevin Shah Caleb Hao Yi-Chen Wu Aashish John Raj K. Narayan Chunyan Li |
| author_facet | Keren Powell Kevin Shah Caleb Hao Yi-Chen Wu Aashish John Raj K. Narayan Chunyan Li |
| author_sort | Keren Powell |
| collection | DOAJ |
| description | Abstract Hemorrhagic shock (HS), a major cause of early death from trauma, accounts for around 40% of mortality, with 33–56% of these deaths occurring before the patient reaches a medical facility. Intravenous fluid therapy and blood transfusions are the cornerstone of treating HS. However, these options may not be available soon after the injury, resulting in death or a poorer quality of survival. Therefore, new strategies are needed to manage HS patients before they can receive definitive care. Recently, various forms of neuromodulation have been investigated as possible supplementary treatments for HS in the prehospital phase of care. Here, we provide an overview of neuromodulation methods that show promise to treat HS, such as vagus nerve stimulation, electroacupuncture, trigeminal nerve stimulation, and phrenic nerve stimulation and outline their possible mechanisms in the treatment of HS. Although all of these approaches are only validated in the preclinical models of HS and are yet to be translated to clinical settings, they clearly represent a paradigm shift in the way that this deadly condition is managed in the future. |
| first_indexed | 2024-12-22T06:29:50Z |
| format | Article |
| id | doaj.art-7ccc4b6c85da40aa93930c1de42b4469 |
| institution | Directory Open Access Journal |
| issn | 2332-8886 |
| language | English |
| last_indexed | 2024-12-22T06:29:50Z |
| publishDate | 2019-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Bioelectronic Medicine |
| spelling | doaj.art-7ccc4b6c85da40aa93930c1de42b44692022-12-21T18:35:45ZengBMCBioelectronic Medicine2332-88862019-10-01511710.1186/s42234-019-0033-zNeuromodulation as a new avenue for resuscitation in hemorrhagic shockKeren Powell0Kevin Shah1Caleb Hao2Yi-Chen Wu3Aashish John4Raj K. Narayan5Chunyan Li6Translational Brain Research Laboratory, Feinstein Institutes for Medical ResearchDepartment of Neurosurgery, Zucker School of Medicine at Hofstra/NorthwellTranslational Brain Research Laboratory, Feinstein Institutes for Medical ResearchTranslational Brain Research Laboratory, Feinstein Institutes for Medical ResearchTranslational Brain Research Laboratory, Feinstein Institutes for Medical ResearchTranslational Brain Research Laboratory, Feinstein Institutes for Medical ResearchTranslational Brain Research Laboratory, Feinstein Institutes for Medical ResearchAbstract Hemorrhagic shock (HS), a major cause of early death from trauma, accounts for around 40% of mortality, with 33–56% of these deaths occurring before the patient reaches a medical facility. Intravenous fluid therapy and blood transfusions are the cornerstone of treating HS. However, these options may not be available soon after the injury, resulting in death or a poorer quality of survival. Therefore, new strategies are needed to manage HS patients before they can receive definitive care. Recently, various forms of neuromodulation have been investigated as possible supplementary treatments for HS in the prehospital phase of care. Here, we provide an overview of neuromodulation methods that show promise to treat HS, such as vagus nerve stimulation, electroacupuncture, trigeminal nerve stimulation, and phrenic nerve stimulation and outline their possible mechanisms in the treatment of HS. Although all of these approaches are only validated in the preclinical models of HS and are yet to be translated to clinical settings, they clearly represent a paradigm shift in the way that this deadly condition is managed in the future.http://link.springer.com/article/10.1186/s42234-019-0033-zHemorrhagic shockNeuromodulationVagus nerve stimulationTrigeminal nerve stimulationPhrenic nerve stimulationElectroacupuncture |
| spellingShingle | Keren Powell Kevin Shah Caleb Hao Yi-Chen Wu Aashish John Raj K. Narayan Chunyan Li Neuromodulation as a new avenue for resuscitation in hemorrhagic shock Bioelectronic Medicine Hemorrhagic shock Neuromodulation Vagus nerve stimulation Trigeminal nerve stimulation Phrenic nerve stimulation Electroacupuncture |
| title | Neuromodulation as a new avenue for resuscitation in hemorrhagic shock |
| title_full | Neuromodulation as a new avenue for resuscitation in hemorrhagic shock |
| title_fullStr | Neuromodulation as a new avenue for resuscitation in hemorrhagic shock |
| title_full_unstemmed | Neuromodulation as a new avenue for resuscitation in hemorrhagic shock |
| title_short | Neuromodulation as a new avenue for resuscitation in hemorrhagic shock |
| title_sort | neuromodulation as a new avenue for resuscitation in hemorrhagic shock |
| topic | Hemorrhagic shock Neuromodulation Vagus nerve stimulation Trigeminal nerve stimulation Phrenic nerve stimulation Electroacupuncture |
| url | http://link.springer.com/article/10.1186/s42234-019-0033-z |
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