Role of melatonin in attenuation of hemodynamic response to intubation and anesthetic requirements: a randomized, controlled, double-blind study
Background: Melatonin has been studied to have anxiolytic, sedative, and analgesic effects. However, there is limited data on the effect of melatonin in the attenuation of hemodynamic response to intubation. We aimed to study whether preanesthetic oral melatonin attenuates hemodynamic responses to i...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Brazilian Journal of Anesthesiology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0104001421003390 |
| _version_ | 1797786575221817344 |
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| author | Rakesh Kumar Kamlesh Kumari Sarita Janweja Rakesh Kumar Manoj Verma Ankur Sharma Bharat Paliwal Rama Kishan |
| author_facet | Rakesh Kumar Kamlesh Kumari Sarita Janweja Rakesh Kumar Manoj Verma Ankur Sharma Bharat Paliwal Rama Kishan |
| author_sort | Rakesh Kumar |
| collection | DOAJ |
| description | Background: Melatonin has been studied to have anxiolytic, sedative, and analgesic effects. However, there is limited data on the effect of melatonin in the attenuation of hemodynamic response to intubation. We aimed to study whether preanesthetic oral melatonin attenuates hemodynamic responses to intubation and anesthetic requirements. Methods: Sixty-four patients scheduled for laparoscopic cholecystectomy were randomized into melatonin or placebo group (n...=...32 each). Melatonin group received two tablets (3...mg each) of melatonin, and the placebo group received two tablets of vitamin D3 120...min before induction. Hemodynamic parameters were recorded during induction and postintubation for 15...minutes. Total induction dose of propofol, total intraoperative fentanyl consumption, and adverse effects of melatonin were also noted. Results: Postintubation rise in heart rate (HR) was less in the melatonin group compared to the placebo group (10.59% vs. 37.08% at 1...min, respectively) (p...<...0.0001). Maximum percentage increase in systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean blood pressure (MBP) was lesser in melatonin group than placebo group (SBP 9.25% vs. 37.73%, DBP 10.58% vs. 35.51%, MBP 9.99% vs. 36.45% at 1 min postintubation. respectively) (p...<...0.0001). Induction dose of propofol (1.42 mg.kg-1 vs. 2.01...mg.kg-1) and the number of patients requiring additional fentanyl intraoperatively (3 vs. 11) were also significantly reduced in the melatonin group. Conclusion: Premedication with 6...mg of oral melatonin resulted in significant attenuation of postintubation rise in HR, SBP, DBP, and MBP. It also reduced the induction dose of propofol, total intraoperative fentanyl consumption without any adverse effects. |
| first_indexed | 2024-03-13T01:10:45Z |
| format | Article |
| id | doaj.art-7ccc89ba3c584667aeb09ce71e898a3f |
| institution | Directory Open Access Journal |
| issn | 0104-0014 |
| language | English |
| last_indexed | 2024-03-13T01:10:45Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Anesthesiology |
| spelling | doaj.art-7ccc89ba3c584667aeb09ce71e898a3f2023-07-06T04:16:55ZengElsevierBrazilian Journal of Anesthesiology0104-00142023-07-01734434440Role of melatonin in attenuation of hemodynamic response to intubation and anesthetic requirements: a randomized, controlled, double-blind studyRakesh Kumar0Kamlesh Kumari1Sarita Janweja2Rakesh Kumar3Manoj Verma4Ankur Sharma5Bharat Paliwal6Rama Kishan7Apex Multispecialty Hospital, Sriganganagar, IndiaAll India Institute of Medical Sciences, Department of Anesthesiology and Critical Care, Jodhpur, India; Corresponding author.Dr. S.N. Medical College, Department of Anesthesiology and Critical Care, Jodhpur, IndiaAll India Institute of Medical Sciences, Department of Anesthesiology and Critical Care, Jodhpur, IndiaDr. S.N. Medical College, Department of Community Medicine, Jodhpur, IndiaAll India Institute of Medical Sciences, Department of Anesthesiology and Critical Care, Jodhpur, IndiaAll India Institute of Medical Sciences, Department of Anesthesiology and Critical Care, Jodhpur, IndiaDr. S.N. Medical College, Department of Orthopedics, Jodhpur, IndiaBackground: Melatonin has been studied to have anxiolytic, sedative, and analgesic effects. However, there is limited data on the effect of melatonin in the attenuation of hemodynamic response to intubation. We aimed to study whether preanesthetic oral melatonin attenuates hemodynamic responses to intubation and anesthetic requirements. Methods: Sixty-four patients scheduled for laparoscopic cholecystectomy were randomized into melatonin or placebo group (n...=...32 each). Melatonin group received two tablets (3...mg each) of melatonin, and the placebo group received two tablets of vitamin D3 120...min before induction. Hemodynamic parameters were recorded during induction and postintubation for 15...minutes. Total induction dose of propofol, total intraoperative fentanyl consumption, and adverse effects of melatonin were also noted. Results: Postintubation rise in heart rate (HR) was less in the melatonin group compared to the placebo group (10.59% vs. 37.08% at 1...min, respectively) (p...<...0.0001). Maximum percentage increase in systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean blood pressure (MBP) was lesser in melatonin group than placebo group (SBP 9.25% vs. 37.73%, DBP 10.58% vs. 35.51%, MBP 9.99% vs. 36.45% at 1 min postintubation. respectively) (p...<...0.0001). Induction dose of propofol (1.42 mg.kg-1 vs. 2.01...mg.kg-1) and the number of patients requiring additional fentanyl intraoperatively (3 vs. 11) were also significantly reduced in the melatonin group. Conclusion: Premedication with 6...mg of oral melatonin resulted in significant attenuation of postintubation rise in HR, SBP, DBP, and MBP. It also reduced the induction dose of propofol, total intraoperative fentanyl consumption without any adverse effects.http://www.sciencedirect.com/science/article/pii/S0104001421003390HemodynamicsIntubationLaryngoscopyMelatoninPremedicationPropofol |
| spellingShingle | Rakesh Kumar Kamlesh Kumari Sarita Janweja Rakesh Kumar Manoj Verma Ankur Sharma Bharat Paliwal Rama Kishan Role of melatonin in attenuation of hemodynamic response to intubation and anesthetic requirements: a randomized, controlled, double-blind study Brazilian Journal of Anesthesiology Hemodynamics Intubation Laryngoscopy Melatonin Premedication Propofol |
| title | Role of melatonin in attenuation of hemodynamic response to intubation and anesthetic requirements: a randomized, controlled, double-blind study |
| title_full | Role of melatonin in attenuation of hemodynamic response to intubation and anesthetic requirements: a randomized, controlled, double-blind study |
| title_fullStr | Role of melatonin in attenuation of hemodynamic response to intubation and anesthetic requirements: a randomized, controlled, double-blind study |
| title_full_unstemmed | Role of melatonin in attenuation of hemodynamic response to intubation and anesthetic requirements: a randomized, controlled, double-blind study |
| title_short | Role of melatonin in attenuation of hemodynamic response to intubation and anesthetic requirements: a randomized, controlled, double-blind study |
| title_sort | role of melatonin in attenuation of hemodynamic response to intubation and anesthetic requirements a randomized controlled double blind study |
| topic | Hemodynamics Intubation Laryngoscopy Melatonin Premedication Propofol |
| url | http://www.sciencedirect.com/science/article/pii/S0104001421003390 |
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