T regulatory cells metabolism: The influence on functional properties and treatment potential
CD4+CD25highFoxP3+ regulatory T cells (Tregs) constitute a small but substantial fraction of lymphocytes in the immune system. Tregs control inflammation associated with infections but also when it is improperly directed against its tissues or cells. The ability of Tregs to suppress (inhibit) the im...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1122063/full |
| _version_ | 1797860825513328640 |
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| author | Martyna Tomaszewicz Martyna Tomaszewicz Anna Ronowska Maciej Zieliński Maciej Zieliński Agnieszka Jankowska-Kulawy Piotr Trzonkowski Piotr Trzonkowski |
| author_facet | Martyna Tomaszewicz Martyna Tomaszewicz Anna Ronowska Maciej Zieliński Maciej Zieliński Agnieszka Jankowska-Kulawy Piotr Trzonkowski Piotr Trzonkowski |
| author_sort | Martyna Tomaszewicz |
| collection | DOAJ |
| description | CD4+CD25highFoxP3+ regulatory T cells (Tregs) constitute a small but substantial fraction of lymphocytes in the immune system. Tregs control inflammation associated with infections but also when it is improperly directed against its tissues or cells. The ability of Tregs to suppress (inhibit) the immune system is possible due to direct interactions with other cells but also in a paracrine fashion via the secretion of suppressive compounds. Today, attempts are made to use Tregs to treat autoimmune diseases, allergies, and rejection after bone marrow or organ transplantation. There is strong evidence that the metabolic program of Tregs is connected with the phenotype and function of these cells. A modulation towards a particular metabolic stage of Tregs may improve or weaken cells’ stability and function. This may be an essential tool to drive the immune system keeping it activated during infections or suppressed when autoimmunity occurs. |
| first_indexed | 2024-04-09T21:52:08Z |
| format | Article |
| id | doaj.art-7ccddd1bdad4494c9e63531c65d6245c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T21:52:08Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-7ccddd1bdad4494c9e63531c65d6245c2023-03-24T14:09:05ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-03-011410.3389/fimmu.2023.11220631122063T regulatory cells metabolism: The influence on functional properties and treatment potentialMartyna Tomaszewicz0Martyna Tomaszewicz1Anna Ronowska2Maciej Zieliński3Maciej Zieliński4Agnieszka Jankowska-Kulawy5Piotr Trzonkowski6Piotr Trzonkowski7Department of Medical Immunology, Faculty of Medicine, Medical University of Gdańsk, Gdanísk, PolandPoltreg S.A., Gdanísk, PolandDepartment of Laboratory Medicine, Faculty of Medicine, Medical University of Gdańsk, Gdanísk, PolandDepartment of Medical Immunology, Faculty of Medicine, Medical University of Gdańsk, Gdanísk, PolandPoltreg S.A., Gdanísk, PolandDepartment of Laboratory Medicine, Faculty of Medicine, Medical University of Gdańsk, Gdanísk, PolandDepartment of Medical Immunology, Faculty of Medicine, Medical University of Gdańsk, Gdanísk, PolandPoltreg S.A., Gdanísk, PolandCD4+CD25highFoxP3+ regulatory T cells (Tregs) constitute a small but substantial fraction of lymphocytes in the immune system. Tregs control inflammation associated with infections but also when it is improperly directed against its tissues or cells. The ability of Tregs to suppress (inhibit) the immune system is possible due to direct interactions with other cells but also in a paracrine fashion via the secretion of suppressive compounds. Today, attempts are made to use Tregs to treat autoimmune diseases, allergies, and rejection after bone marrow or organ transplantation. There is strong evidence that the metabolic program of Tregs is connected with the phenotype and function of these cells. A modulation towards a particular metabolic stage of Tregs may improve or weaken cells’ stability and function. This may be an essential tool to drive the immune system keeping it activated during infections or suppressed when autoimmunity occurs.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1122063/fullmetabolismautoimmunityglycolysisfatty acid oxidationmTORischemia |
| spellingShingle | Martyna Tomaszewicz Martyna Tomaszewicz Anna Ronowska Maciej Zieliński Maciej Zieliński Agnieszka Jankowska-Kulawy Piotr Trzonkowski Piotr Trzonkowski T regulatory cells metabolism: The influence on functional properties and treatment potential Frontiers in Immunology metabolism autoimmunity glycolysis fatty acid oxidation mTOR ischemia |
| title | T regulatory cells metabolism: The influence on functional properties and treatment potential |
| title_full | T regulatory cells metabolism: The influence on functional properties and treatment potential |
| title_fullStr | T regulatory cells metabolism: The influence on functional properties and treatment potential |
| title_full_unstemmed | T regulatory cells metabolism: The influence on functional properties and treatment potential |
| title_short | T regulatory cells metabolism: The influence on functional properties and treatment potential |
| title_sort | t regulatory cells metabolism the influence on functional properties and treatment potential |
| topic | metabolism autoimmunity glycolysis fatty acid oxidation mTOR ischemia |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1122063/full |
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