Co-Amorphous Solid Dispersions for Solubility and Absorption Improvement of Drugs: Composition, Preparation, Characterization and Formulations for Oral Delivery

Co-Amorphous Solid Dispersions for Solubility and Absorption Improvement of Drugs: Composition, Preparation, Characterization and Formulations for Oral Delivery

The amorphous solid state offers an improved apparent solubility and dissolution rate. However, due to thermodynamic instability and recrystallization tendencies during processing, storage and dissolution, their potential application is limited. For this reason, the production of amorphous drugs wit...

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Bibliographic Details
Main Authors: Anna Karagianni, Kyriakos Kachrimanis, Ioannis Nikolakakis
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Pharmaceutics
Subjects:
co-amorphous solid dispersions
drug-drug co-amorphous
drug-carboxylic acids
drug-amino acids
dissolution
absorption
Online Access:http://www.mdpi.com/1999-4923/10/3/98

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