Vitamin D status in patients with autoimmune bullous dermatoses: a meta-analysis
Background The association between autoimmune bullous dermatoses (AIBD) and serum vitamin D levels has been revealed by some studies, however, inconsistent. Objectives We aimed to evaluate the difference in vitamin D status between AIBD patients and controls. Methods We searched the studies about th...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-04-01
|
| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2020.1810606 |
| Summary: | Background The association between autoimmune bullous dermatoses (AIBD) and serum vitamin D levels has been revealed by some studies, however, inconsistent. Objectives We aimed to evaluate the difference in vitamin D status between AIBD patients and controls. Methods We searched the studies about the vitamin D status of AIBD patients in electronic databases published before January 2020. Mean difference (MD) and 95% confidence intervals (CI) of eligible studies were calculated in meta-analyses of 25(OH)D levels. Pooled odds ratio (OR) and 95%CI were used in analyses of the prevalence of hypovitaminosis D. Different subgroup analyses, sensitivity analyses and publication bias assessment were conducted. Results We included nine case-control studies in the meta-analysis. Vitamin D level was significantly lower in both pemphigus (MD: −7.02, 95%CI: −10.30 to −3.74) and bullous pemphigoid (BP) (MD: −6.37, 95%CI: −12.15 to −0.58) patients than that in controls. Active pemphigus patients were at higher risk of presenting hypovitaminosis D (OR: 6.95, 95%CI: 1.37–35.25). Conclusions Abnormal vitamin D status are more common in AIBD patients than that in general population. Therefore, regular monitoring of vitamin D levels and vitamin D supplementation should be considered as part of the management strategy for AIBD. |
|---|---|
| ISSN: | 0954-6634 1471-1753 |