Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosis
To evaluate the clinical efficacy of etonogestrel subcutaneous implant (ENG-SCI) with that of the levonorgestrel-releasing intrauterine system (LNG-IUD) for adenomyosis treatment. A prospective randomized cohort study was conducted including 108 patients (50 patients in ENG-SCI group and 58 in the L...
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| Format: | Article |
| Language: | English |
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De Gruyter
2024-03-01
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| Series: | Open Medicine |
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| Online Access: | https://doi.org/10.1515/med-2024-0914 |
| _version_ | 1797246600510177280 |
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| author | Wei Anwen Tang Xuedong Yang Wenjuan Zhou Jianqing Zhu Weili Pan Shan |
| author_facet | Wei Anwen Tang Xuedong Yang Wenjuan Zhou Jianqing Zhu Weili Pan Shan |
| author_sort | Wei Anwen |
| collection | DOAJ |
| description | To evaluate the clinical efficacy of etonogestrel subcutaneous implant (ENG-SCI) with that of the levonorgestrel-releasing intrauterine system (LNG-IUD) for adenomyosis treatment. A prospective randomized cohort study was conducted including 108 patients (50 patients in ENG-SCI group and 58 in the LNG-IUD group) with adenomyosis from January 2019 to July 2021. After 3 months of treatment, both ENG-SCI group and LNG-IUD group showed significant improvement in patients’ visual analog scale, pictorial blood loss assessment chart (PBAC), and uterine volume (P ＜ 0.05). The uterine volume of patients in LNG-IUD group decreased more significantly than that in the ENG-SCI group since 3 months of treatment. The PBAC score in the LNG-IUD group improved better than that in the ENG-SCI group since 6 months of treatment (P ＜ 0.05). No significant difference in the occurrence rate of ideal vaginal bleeding patterns and the hemoglobin levels between the two groups was observed. The ENG-SCI group had a higher probability of weight gain and progesterone-related side effects (P ＜ 0.05). Both ENG-SCI and LNG-IUD were effective in treatment of adenomyosis. However, LNG-IUD had a more significant effect in treating adenomyosis-related dysmenorrhea, excessive menstrual flow, anemia, and uterine enlargement, with relatively fewer side effects. |
| first_indexed | 2024-04-24T19:45:23Z |
| format | Article |
| id | doaj.art-7cd64099aa5c4d579fb76c9a0d45ce1d |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-04-24T19:45:23Z |
| publishDate | 2024-03-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-7cd64099aa5c4d579fb76c9a0d45ce1d2024-03-25T07:29:05ZengDe GruyterOpen Medicine2391-54632024-03-0119141729.e110.1515/med-2024-0914Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosisWei Anwen0Tang Xuedong1Yang Wenjuan2Zhou Jianqing3Zhu Weili4Pan Shan5Department of Gynecology, Jiaxing Women and Children’s Hospital Wenzhou Medical University, Jiaxing314051, ChinaDepartment of Gynecology, Jiaxing Women and Children’s Hospital Wenzhou Medical University, Jiaxing314051, ChinaDepartment of Gynecology, Jiaxing Women and Children’s Hospital Wenzhou Medical University, Jiaxing314051, ChinaDepartment of Gynecology, Jiaxing Women and Children’s Hospital Wenzhou Medical University, Jiaxing314051, ChinaDepartment of Gynecology, Jiaxing Women and Children’s Hospital Wenzhou Medical University, Jiaxing314051, ChinaDepartment of Gynecology, Jiaxing Women and Children’s Hospital Wenzhou Medical University, Jiaxing314051, ChinaTo evaluate the clinical efficacy of etonogestrel subcutaneous implant (ENG-SCI) with that of the levonorgestrel-releasing intrauterine system (LNG-IUD) for adenomyosis treatment. A prospective randomized cohort study was conducted including 108 patients (50 patients in ENG-SCI group and 58 in the LNG-IUD group) with adenomyosis from January 2019 to July 2021. After 3 months of treatment, both ENG-SCI group and LNG-IUD group showed significant improvement in patients’ visual analog scale, pictorial blood loss assessment chart (PBAC), and uterine volume (P ＜ 0.05). The uterine volume of patients in LNG-IUD group decreased more significantly than that in the ENG-SCI group since 3 months of treatment. The PBAC score in the LNG-IUD group improved better than that in the ENG-SCI group since 6 months of treatment (P ＜ 0.05). No significant difference in the occurrence rate of ideal vaginal bleeding patterns and the hemoglobin levels between the two groups was observed. The ENG-SCI group had a higher probability of weight gain and progesterone-related side effects (P ＜ 0.05). Both ENG-SCI and LNG-IUD were effective in treatment of adenomyosis. However, LNG-IUD had a more significant effect in treating adenomyosis-related dysmenorrhea, excessive menstrual flow, anemia, and uterine enlargement, with relatively fewer side effects.https://doi.org/10.1515/med-2024-0914adenomyosisetonogestrelimplantlevonorgestreldysmenorrheamenorrhagia |
| spellingShingle | Wei Anwen Tang Xuedong Yang Wenjuan Zhou Jianqing Zhu Weili Pan Shan Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosis Open Medicine adenomyosis etonogestrel implant levonorgestrel dysmenorrhea menorrhagia |
| title | Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosis |
| title_full | Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosis |
| title_fullStr | Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosis |
| title_full_unstemmed | Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosis |
| title_short | Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosis |
| title_sort | efficacy of etonogestrel subcutaneous implants versus the levonorgestrel releasing intrauterine system in the conservative treatment of adenomyosis |
| topic | adenomyosis etonogestrel implant levonorgestrel dysmenorrhea menorrhagia |
| url | https://doi.org/10.1515/med-2024-0914 |
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