Sinomenine Attenuates Angiotensin II-Induced Autophagy via Inhibition of P47-Phox Translocation to the Membrane and Influences Reactive Oxygen Species Generation in Podocytes

Sinomenine Attenuates Angiotensin II-Induced Autophagy via Inhibition of P47-Phox Translocation to the Membrane and Influences Reactive Oxygen Species Generation in Podocytes

Background/Aims: Sinomenine, a pure alkaloid extracted from the Chinese medicinal plant Sinomenium acutum, and sinomenine hydrochloride (SN) has been successfully used for the therapy of rheumatoid arthritis (RA) and kidney diseases. Autophagy is a cytoprotective mechanism used by podocytes and othe...

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Bibliographic Details
Main Authors: Weili Wang, Juan Cai, Sha Tang, Ying Zhang, Xuejing Gao, Lijiao Xie, Zhirong Mou, Yuzhang Wu, Li Wang, Jingbo Zhang
Format: Article
Language:English
Published: Karger Publishers 2016-02-01
Series:Kidney & Blood Pressure Research
Subjects:
NADPH oxidase
p47-phox
Podocyte
Angiotensin II
Autophagy
Sinomenine
Online Access:http://www.karger.com/Article/FullText/443417

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