Dehydrozingerone, a Curcumin Analog, as a Potential Anti-Prostate Cancer Inhibitor In Vitro and In Vivo
Curcumin (Cur) exhibits biological activities that support its candidacy for cancer treatment. However, there are limitations to its pharmacological effects, such as poor solubility and bioavailability. Notably, the use of Cur analogs has potential for addressing these limitations. Dehydrozingerone...
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| Format: | Article |
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MDPI AG
2020-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/12/2737 |
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| author | Sariya Mapoung Shugo Suzuki Satoshi Fuji Aya Naiki-Ito Hiroyuki Kato Supachai Yodkeeree Natee Sakorn Chitchamai Ovatlarnporn Satoru Takahashi Pornngarm Limtrakul (Dejkriengkraikul) |
| author_facet | Sariya Mapoung Shugo Suzuki Satoshi Fuji Aya Naiki-Ito Hiroyuki Kato Supachai Yodkeeree Natee Sakorn Chitchamai Ovatlarnporn Satoru Takahashi Pornngarm Limtrakul (Dejkriengkraikul) |
| author_sort | Sariya Mapoung |
| collection | DOAJ |
| description | Curcumin (Cur) exhibits biological activities that support its candidacy for cancer treatment. However, there are limitations to its pharmacological effects, such as poor solubility and bioavailability. Notably, the use of Cur analogs has potential for addressing these limitations. Dehydrozingerone (DZG) is a representative of the half-chemical structure of Cur, and many reports have indicated that it is anticancer in vitro. We, therefore, have hypothesized that DZG could inhibit prostate cancer progression both in vitro and in vivo. Results revealed that DZG decreased cell proliferation of rat castration-resistant prostate cancer, PLS10 cells, via induction of the cell cycle arrest in the G1 phase in vitro. In the PLS10 xenograft model, DZG significantly decreased the growth of subcutaneous tumors when compared to the control via the inhibition of cell proliferation and angiogenesis. To prove that DZG could improve the limitations of Cur, an in vivo pharmacokinetic was determined. DZG was detected in the serum at higher concentrations and remained up to 3 h after intraperitoneal injections, which was longer than Cur. DZG also showed superior in vivo tissue distribution than Cur. The results suggest that DZG could be a candidate of the Cur analog that can potentially exert anticancer capabilities in vivo and thereby improve its bioavailability. |
| first_indexed | 2024-03-10T19:12:10Z |
| format | Article |
| id | doaj.art-7cd9ffa9d32f40b69c1af6b92183c97f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T19:12:10Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-7cd9ffa9d32f40b69c1af6b92183c97f2023-11-20T03:41:09ZengMDPI AGMolecules1420-30492020-06-012512273710.3390/molecules25122737Dehydrozingerone, a Curcumin Analog, as a Potential Anti-Prostate Cancer Inhibitor In Vitro and In VivoSariya Mapoung0Shugo Suzuki1Satoshi Fuji2Aya Naiki-Ito3Hiroyuki Kato4Supachai Yodkeeree5Natee Sakorn6Chitchamai Ovatlarnporn7Satoru Takahashi8Pornngarm Limtrakul (Dejkriengkraikul)9Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 5200, ThailandDepartment of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, JapanDepartment of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, JapanDepartment of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, JapanDepartment of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, JapanDepartment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 5200, ThailandDepartment of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90110, ThailandDepartment of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90110, ThailandDepartment of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, JapanDepartment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 5200, ThailandCurcumin (Cur) exhibits biological activities that support its candidacy for cancer treatment. However, there are limitations to its pharmacological effects, such as poor solubility and bioavailability. Notably, the use of Cur analogs has potential for addressing these limitations. Dehydrozingerone (DZG) is a representative of the half-chemical structure of Cur, and many reports have indicated that it is anticancer in vitro. We, therefore, have hypothesized that DZG could inhibit prostate cancer progression both in vitro and in vivo. Results revealed that DZG decreased cell proliferation of rat castration-resistant prostate cancer, PLS10 cells, via induction of the cell cycle arrest in the G1 phase in vitro. In the PLS10 xenograft model, DZG significantly decreased the growth of subcutaneous tumors when compared to the control via the inhibition of cell proliferation and angiogenesis. To prove that DZG could improve the limitations of Cur, an in vivo pharmacokinetic was determined. DZG was detected in the serum at higher concentrations and remained up to 3 h after intraperitoneal injections, which was longer than Cur. DZG also showed superior in vivo tissue distribution than Cur. The results suggest that DZG could be a candidate of the Cur analog that can potentially exert anticancer capabilities in vivo and thereby improve its bioavailability.https://www.mdpi.com/1420-3049/25/12/2737curcumin analogsdehydrozingeroneprostate cancerpharmacokineticanticancer |
| spellingShingle | Sariya Mapoung Shugo Suzuki Satoshi Fuji Aya Naiki-Ito Hiroyuki Kato Supachai Yodkeeree Natee Sakorn Chitchamai Ovatlarnporn Satoru Takahashi Pornngarm Limtrakul (Dejkriengkraikul) Dehydrozingerone, a Curcumin Analog, as a Potential Anti-Prostate Cancer Inhibitor In Vitro and In Vivo Molecules curcumin analogs dehydrozingerone prostate cancer pharmacokinetic anticancer |
| title | Dehydrozingerone, a Curcumin Analog, as a Potential Anti-Prostate Cancer Inhibitor In Vitro and In Vivo |
| title_full | Dehydrozingerone, a Curcumin Analog, as a Potential Anti-Prostate Cancer Inhibitor In Vitro and In Vivo |
| title_fullStr | Dehydrozingerone, a Curcumin Analog, as a Potential Anti-Prostate Cancer Inhibitor In Vitro and In Vivo |
| title_full_unstemmed | Dehydrozingerone, a Curcumin Analog, as a Potential Anti-Prostate Cancer Inhibitor In Vitro and In Vivo |
| title_short | Dehydrozingerone, a Curcumin Analog, as a Potential Anti-Prostate Cancer Inhibitor In Vitro and In Vivo |
| title_sort | dehydrozingerone a curcumin analog as a potential anti prostate cancer inhibitor in vitro and in vivo |
| topic | curcumin analogs dehydrozingerone prostate cancer pharmacokinetic anticancer |
| url | https://www.mdpi.com/1420-3049/25/12/2737 |
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