Visual function and quality of life in patients with Stevens-Johnson syndrome who received acute protocol-based ocular care
Purpose: To report visual function and quality of life (VF/QOL) using the National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and the ocular surface disease index (OSDI) in patients in the chronic phase of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN).Methods: The NEI-V...
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| Format: | Article |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Toxicology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/ftox.2022.992696/full |
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| author | Swapna S. Shanbhag Swapna S. Shanbhag Mohammad A. Tahboub James Chodosh Hajirah N. Saeed Hajirah N. Saeed Hajirah N. Saeed |
| author_facet | Swapna S. Shanbhag Swapna S. Shanbhag Mohammad A. Tahboub James Chodosh Hajirah N. Saeed Hajirah N. Saeed Hajirah N. Saeed |
| author_sort | Swapna S. Shanbhag |
| collection | DOAJ |
| description | Purpose: To report visual function and quality of life (VF/QOL) using the National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and the ocular surface disease index (OSDI) in patients in the chronic phase of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN).Methods: The NEI-VFQ-25 questionnaire was administered to 15 patients who received protocol-based care in the form of topical medications with or without amniotic membrane transplantation (AMT) for acute SJS/TEN. The scores obtained were compared with scores from a healthy population. The associations between the NEI-VFQ-25 and dry eye symptoms as measured by OSDI questionnaire were also studied.Results: Patients were surveyed at a mean of 4.47 ± 2.22 years after acute SJS/TEN. Eleven patients received AMT in the acute phase. The median best corrected visual acuity at the time of administration of the questionnaire was 20/20. The mean composite NEI-VFQ-25 score was 86.48 ± 12. Patients who received protocol-based treatment in the acute phase of SJS/TEN had comparable NEI-VFQ-25 scores with healthy subjects on all subscales except ocular pain (p = 0.027) and mental health (p = 0.014), which were significantly reduced. The NEI-VFQ-25 composite scores significantly correlated with OSDI (R = -0.75, p = 0.001).Conclusion: A protocol-based management strategy composed of early ophthalmic evaluation, grading based on severity, the use of topical corticosteroids and AMT in the acute phase of SJS/TEN in patients with ocular complications helped preserve the VF/QOL. This study highlights the impact of appropriate management of the ocular complications in the acute phase of SJS/TEN. |
| first_indexed | 2024-04-13T14:54:20Z |
| format | Article |
| id | doaj.art-7cdbd367750e4b499fd8eebe6b0e0353 |
| institution | Directory Open Access Journal |
| issn | 2673-3080 |
| language | English |
| last_indexed | 2024-04-13T14:54:20Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Toxicology |
| spelling | doaj.art-7cdbd367750e4b499fd8eebe6b0e03532022-12-22T02:42:29ZengFrontiers Media S.A.Frontiers in Toxicology2673-30802022-11-01410.3389/ftox.2022.992696992696Visual function and quality of life in patients with Stevens-Johnson syndrome who received acute protocol-based ocular careSwapna S. Shanbhag0Swapna S. Shanbhag1Mohammad A. Tahboub2James Chodosh3Hajirah N. Saeed4Hajirah N. Saeed5Hajirah N. Saeed6The Cornea Institute, L. V. Prasad Eye Institute, Hyderabad, IndiaDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, United StatesDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, United StatesDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, United StatesDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, United StatesDepartment of Ophthalmology, Illinois Eye and Ear Infirmary, University of Illinois Chicago, Chicago, IL, United StatesDepartment of Ophthalmology, Loyola University Medical Center, Chicago, IL, United StatesPurpose: To report visual function and quality of life (VF/QOL) using the National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and the ocular surface disease index (OSDI) in patients in the chronic phase of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN).Methods: The NEI-VFQ-25 questionnaire was administered to 15 patients who received protocol-based care in the form of topical medications with or without amniotic membrane transplantation (AMT) for acute SJS/TEN. The scores obtained were compared with scores from a healthy population. The associations between the NEI-VFQ-25 and dry eye symptoms as measured by OSDI questionnaire were also studied.Results: Patients were surveyed at a mean of 4.47 ± 2.22 years after acute SJS/TEN. Eleven patients received AMT in the acute phase. The median best corrected visual acuity at the time of administration of the questionnaire was 20/20. The mean composite NEI-VFQ-25 score was 86.48 ± 12. Patients who received protocol-based treatment in the acute phase of SJS/TEN had comparable NEI-VFQ-25 scores with healthy subjects on all subscales except ocular pain (p = 0.027) and mental health (p = 0.014), which were significantly reduced. The NEI-VFQ-25 composite scores significantly correlated with OSDI (R = -0.75, p = 0.001).Conclusion: A protocol-based management strategy composed of early ophthalmic evaluation, grading based on severity, the use of topical corticosteroids and AMT in the acute phase of SJS/TEN in patients with ocular complications helped preserve the VF/QOL. This study highlights the impact of appropriate management of the ocular complications in the acute phase of SJS/TEN.https://www.frontiersin.org/articles/10.3389/ftox.2022.992696/fullstevens-johnson syndrome (SJS)toxic epidermal necrolysis (TEN)visual functionnational eye institute visual function questionnaire (NEI-VFQ-25)ocular surface disease index (OSDI) |
| spellingShingle | Swapna S. Shanbhag Swapna S. Shanbhag Mohammad A. Tahboub James Chodosh Hajirah N. Saeed Hajirah N. Saeed Hajirah N. Saeed Visual function and quality of life in patients with Stevens-Johnson syndrome who received acute protocol-based ocular care Frontiers in Toxicology stevens-johnson syndrome (SJS) toxic epidermal necrolysis (TEN) visual function national eye institute visual function questionnaire (NEI-VFQ-25) ocular surface disease index (OSDI) |
| title | Visual function and quality of life in patients with Stevens-Johnson syndrome who received acute protocol-based ocular care |
| title_full | Visual function and quality of life in patients with Stevens-Johnson syndrome who received acute protocol-based ocular care |
| title_fullStr | Visual function and quality of life in patients with Stevens-Johnson syndrome who received acute protocol-based ocular care |
| title_full_unstemmed | Visual function and quality of life in patients with Stevens-Johnson syndrome who received acute protocol-based ocular care |
| title_short | Visual function and quality of life in patients with Stevens-Johnson syndrome who received acute protocol-based ocular care |
| title_sort | visual function and quality of life in patients with stevens johnson syndrome who received acute protocol based ocular care |
| topic | stevens-johnson syndrome (SJS) toxic epidermal necrolysis (TEN) visual function national eye institute visual function questionnaire (NEI-VFQ-25) ocular surface disease index (OSDI) |
| url | https://www.frontiersin.org/articles/10.3389/ftox.2022.992696/full |
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