Discovering the drivers of clonal hematopoiesis
Identifying the genetic drivers of clonal haematopoiesis (CH) has been challenging due to their low frequencies and a lack of adequate tools. Here, the authors use a reverse calling to detect blood somatic mutations and the IntOGen pipeline to identify CH drivers in large cancer genomics data sets b...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31878-0 |
| _version_ | 1817968657568890880 |
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| author | Oriol Pich Iker Reyes-Salazar Abel Gonzalez-Perez Nuria Lopez-Bigas |
| author_facet | Oriol Pich Iker Reyes-Salazar Abel Gonzalez-Perez Nuria Lopez-Bigas |
| author_sort | Oriol Pich |
| collection | DOAJ |
| description | Identifying the genetic drivers of clonal haematopoiesis (CH) has been challenging due to their low frequencies and a lack of adequate tools. Here, the authors use a reverse calling to detect blood somatic mutations and the IntOGen pipeline to identify CH drivers in large cancer genomics data sets based on signals of positive selection. |
| first_indexed | 2024-04-13T20:10:50Z |
| format | Article |
| id | doaj.art-7cdd08da9e5f4c1dab238047d9bd0d31 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T20:10:50Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7cdd08da9e5f4c1dab238047d9bd0d312022-12-22T02:31:50ZengNature PortfolioNature Communications2041-17232022-07-0113111210.1038/s41467-022-31878-0Discovering the drivers of clonal hematopoiesisOriol Pich0Iker Reyes-Salazar1Abel Gonzalez-Perez2Nuria Lopez-Bigas3Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri ReixacInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri ReixacInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri ReixacInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri ReixacIdentifying the genetic drivers of clonal haematopoiesis (CH) has been challenging due to their low frequencies and a lack of adequate tools. Here, the authors use a reverse calling to detect blood somatic mutations and the IntOGen pipeline to identify CH drivers in large cancer genomics data sets based on signals of positive selection.https://doi.org/10.1038/s41467-022-31878-0 |
| spellingShingle | Oriol Pich Iker Reyes-Salazar Abel Gonzalez-Perez Nuria Lopez-Bigas Discovering the drivers of clonal hematopoiesis Nature Communications |
| title | Discovering the drivers of clonal hematopoiesis |
| title_full | Discovering the drivers of clonal hematopoiesis |
| title_fullStr | Discovering the drivers of clonal hematopoiesis |
| title_full_unstemmed | Discovering the drivers of clonal hematopoiesis |
| title_short | Discovering the drivers of clonal hematopoiesis |
| title_sort | discovering the drivers of clonal hematopoiesis |
| url | https://doi.org/10.1038/s41467-022-31878-0 |
| work_keys_str_mv | AT oriolpich discoveringthedriversofclonalhematopoiesis AT ikerreyessalazar discoveringthedriversofclonalhematopoiesis AT abelgonzalezperez discoveringthedriversofclonalhematopoiesis AT nurialopezbigas discoveringthedriversofclonalhematopoiesis |