The potential influence of interferon-α on the growth of the growing teratoma: A case report
Growing teratoma syndrome (GTS) is rare. It is fatal if the teratoma is unresectable. A standard systemic therapy is not established. The efficacy of interferon-alpha (IFN-α) for GTS was described but the treatment periods were relatively short. A 23-year-old Japanese male with bulky retroperitoneal...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Urology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214442022002789 |
| _version_ | 1811190256293117952 |
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| author | Akinobu Katami Shin-Ichi Hisasue Hiromichi Sakurai Koji Kawai Yuichiro Hayashi Jun Miyazaki |
| author_facet | Akinobu Katami Shin-Ichi Hisasue Hiromichi Sakurai Koji Kawai Yuichiro Hayashi Jun Miyazaki |
| author_sort | Akinobu Katami |
| collection | DOAJ |
| description | Growing teratoma syndrome (GTS) is rare. It is fatal if the teratoma is unresectable. A standard systemic therapy is not established. The efficacy of interferon-alpha (IFN-α) for GTS was described but the treatment periods were relatively short. A 23-year-old Japanese male with bulky retroperitoneal lymph node and multiple lung metastases that progressed to GTS was administered 6 × 106 units of natural IFN-α 2 × /week. Since the IFN-α treatment suppressed both lesions' growth, it was continued for >10 years. The patient is well with controlled metastases (135 months since the IFN-α′s initiation). This is apparently the longest follow-up of INF-α treatment for GTS. |
| first_indexed | 2024-04-11T14:47:15Z |
| format | Article |
| id | doaj.art-7ce208a0eafa4ed5974faed1de0726c2 |
| institution | Directory Open Access Journal |
| issn | 2214-4420 |
| language | English |
| last_indexed | 2024-04-11T14:47:15Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Urology Case Reports |
| spelling | doaj.art-7ce208a0eafa4ed5974faed1de0726c22022-12-22T04:17:35ZengElsevierUrology Case Reports2214-44202022-11-0145102266The potential influence of interferon-α on the growth of the growing teratoma: A case reportAkinobu Katami0Shin-Ichi Hisasue1Hiromichi Sakurai2Koji Kawai3Yuichiro Hayashi4Jun Miyazaki5Department of Urology, International University of Health and Welfare Narita Hospital, Narita, JapanDepartment of Urology, International University of Health and Welfare Narita Hospital, Narita, JapanDepartment of Urology, International University of Health and Welfare Narita Hospital, Narita, JapanDepartment of Urology, International University of Health and Welfare Narita Hospital, Narita, JapanDepartment of Pathology, International University of Health and Welfare Narita Hospital, Narita, JapanDepartment of Urology, International University of Health and Welfare Narita Hospital, Narita, Japan; Corresponding author. Department of Urology, International University of Health and Welfare Narita Hospital, 852 Hatakeda, Narita, Chiba, 286-0124, Japan.Growing teratoma syndrome (GTS) is rare. It is fatal if the teratoma is unresectable. A standard systemic therapy is not established. The efficacy of interferon-alpha (IFN-α) for GTS was described but the treatment periods were relatively short. A 23-year-old Japanese male with bulky retroperitoneal lymph node and multiple lung metastases that progressed to GTS was administered 6 × 106 units of natural IFN-α 2 × /week. Since the IFN-α treatment suppressed both lesions' growth, it was continued for >10 years. The patient is well with controlled metastases (135 months since the IFN-α′s initiation). This is apparently the longest follow-up of INF-α treatment for GTS.http://www.sciencedirect.com/science/article/pii/S2214442022002789Testicular cancerGrowing teratoma syndromeInterferon-α |
| spellingShingle | Akinobu Katami Shin-Ichi Hisasue Hiromichi Sakurai Koji Kawai Yuichiro Hayashi Jun Miyazaki The potential influence of interferon-α on the growth of the growing teratoma: A case report Urology Case Reports Testicular cancer Growing teratoma syndrome Interferon-α |
| title | The potential influence of interferon-α on the growth of the growing teratoma: A case report |
| title_full | The potential influence of interferon-α on the growth of the growing teratoma: A case report |
| title_fullStr | The potential influence of interferon-α on the growth of the growing teratoma: A case report |
| title_full_unstemmed | The potential influence of interferon-α on the growth of the growing teratoma: A case report |
| title_short | The potential influence of interferon-α on the growth of the growing teratoma: A case report |
| title_sort | potential influence of interferon α on the growth of the growing teratoma a case report |
| topic | Testicular cancer Growing teratoma syndrome Interferon-α |
| url | http://www.sciencedirect.com/science/article/pii/S2214442022002789 |
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