Management of Epirubicin Extravasation Injuries of the Hand with Debridement and Flap Cover—A Case Series
Chemotherapy extravasation injury is an iatrogenic injury due to extravasation of the drug from the vessel during infusion therapy. Among various chemotherapeutic drugs, DNA binding vesicants like epirubicin and doxorubicin can lead to extensive tissue necrosis following extravasation. They are comm...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical Publishers, Inc.
2023-10-01
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| Series: | Indian Journal of Plastic Surgery |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1774787 |
| _version_ | 1797454703315910656 |
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| author | Rajesh Yellinedi Mukunda Reddy Damalachervu Rambabu Nuvvula Subramanyeshwar Rao Thammineedi |
| author_facet | Rajesh Yellinedi Mukunda Reddy Damalachervu Rambabu Nuvvula Subramanyeshwar Rao Thammineedi |
| author_sort | Rajesh Yellinedi |
| collection | DOAJ |
| description | Chemotherapy extravasation injury is an iatrogenic injury due to extravasation of the drug from the vessel during infusion therapy. Among various chemotherapeutic drugs, DNA binding vesicants like epirubicin and doxorubicin can lead to extensive tissue necrosis following extravasation. They are commonly used in many chemotherapy regimens including those for carcinoma breast. We present our case series in the management of these wounds with aggressive debridement and regional (pedicled groin)/free flaps (superficial circumflex iliac artery perforator, lateral arm) for cover in five patients. All flaps healed well with patient returning to further treatment in 3 to 4 weeks post-surgery with preservation of hand function. Thus, early recognition of the type of drug that has extravasated is crucial. Regional and free flaps are superior to local flaps because there are no extra incisions and grafts on the limb that has already been injured. |
| first_indexed | 2024-03-09T15:40:57Z |
| format | Article |
| id | doaj.art-7ce2e422cfb24727a1df03dac1353cb6 |
| institution | Directory Open Access Journal |
| issn | 0970-0358 1998-376X |
| language | English |
| last_indexed | 2024-03-09T15:40:57Z |
| publishDate | 2023-10-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | Indian Journal of Plastic Surgery |
| spelling | doaj.art-7ce2e422cfb24727a1df03dac1353cb62023-11-25T02:21:31ZengThieme Medical Publishers, Inc.Indian Journal of Plastic Surgery0970-03581998-376X2023-10-01560543944210.1055/s-0043-1774787Management of Epirubicin Extravasation Injuries of the Hand with Debridement and Flap Cover—A Case SeriesRajesh Yellinedi0Mukunda Reddy Damalachervu1Rambabu Nuvvula2Subramanyeshwar Rao Thammineedi3Department of Plastic and Reconstructive Surgery, Basavatarakam Indo American Cancer Hospital and Research Institute (BIACH&RI), Hyderabad, Telangana, IndiaDepartment of Plastic and Reconstructive Surgery, Basavatarakam Indo American Cancer Hospital and Research Institute (BIACH&RI), Hyderabad, Telangana, IndiaDepartment of Plastic and Reconstructive Surgery, Basavatarakam Indo American Cancer Hospital and Research Institute (BIACH&RI), Hyderabad, Telangana, IndiaDepartment of Surgical Oncology, Basavatarakam Indo American Cancer Hospital and Research Institute (BIACH&RI), Hyderabad, Telangana, IndiaChemotherapy extravasation injury is an iatrogenic injury due to extravasation of the drug from the vessel during infusion therapy. Among various chemotherapeutic drugs, DNA binding vesicants like epirubicin and doxorubicin can lead to extensive tissue necrosis following extravasation. They are commonly used in many chemotherapy regimens including those for carcinoma breast. We present our case series in the management of these wounds with aggressive debridement and regional (pedicled groin)/free flaps (superficial circumflex iliac artery perforator, lateral arm) for cover in five patients. All flaps healed well with patient returning to further treatment in 3 to 4 weeks post-surgery with preservation of hand function. Thus, early recognition of the type of drug that has extravasated is crucial. Regional and free flaps are superior to local flaps because there are no extra incisions and grafts on the limb that has already been injured.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1774787chemotherapy extravasationvesicantsfree flap cover |
| spellingShingle | Rajesh Yellinedi Mukunda Reddy Damalachervu Rambabu Nuvvula Subramanyeshwar Rao Thammineedi Management of Epirubicin Extravasation Injuries of the Hand with Debridement and Flap Cover—A Case Series Indian Journal of Plastic Surgery chemotherapy extravasation vesicants free flap cover |
| title | Management of Epirubicin Extravasation Injuries of the Hand with Debridement and Flap Cover—A Case Series |
| title_full | Management of Epirubicin Extravasation Injuries of the Hand with Debridement and Flap Cover—A Case Series |
| title_fullStr | Management of Epirubicin Extravasation Injuries of the Hand with Debridement and Flap Cover—A Case Series |
| title_full_unstemmed | Management of Epirubicin Extravasation Injuries of the Hand with Debridement and Flap Cover—A Case Series |
| title_short | Management of Epirubicin Extravasation Injuries of the Hand with Debridement and Flap Cover—A Case Series |
| title_sort | management of epirubicin extravasation injuries of the hand with debridement and flap cover a case series |
| topic | chemotherapy extravasation vesicants free flap cover |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1774787 |
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