Rutaecarpine Promotes Adipose Thermogenesis and Protects against HFD-Induced Obesity via AMPK/PGC-1α Pathway

Rutaecarpine Promotes Adipose Thermogenesis and Protects against HFD-Induced Obesity via AMPK/PGC-1α Pathway

Pharmacological activation of adaptive thermogenesis to increase energy expenditure is considered to be a novel strategy for obesity. Peroxisome-proliferator-activated receptor γ co-activator-1α (PGC-1α), which serves as an inducible co-activator in energy expenditure, is highly expressed in brown a...

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Bibliographic Details
Main Authors: Dandan Chen, Yanan Duan, Shuxiang Yu, Xinwen Zhang, Ni Li, Jingya Li
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceuticals
Subjects:
obesity
rutaecarpine
adipocytes
thermogenesis
peroxisome-proliferator-activated receptor γ co-activator-1α
AMP-activated protein kinase
Online Access:https://www.mdpi.com/1424-8247/15/4/469

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