Control of S phase duration: a replication capacity model with E2F transcription at its heart
DNA replication capacity, the maximal amount of DNA a cell can synthesize at any given time during S phase, is controlled by E2F-dependent transcription. Controlling replication capacity limits the replication rate and provides a robust mechanism to keep replication fork speed within an optimal rang...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-03-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2020.1839294 |
| _version_ | 1797677086176968704 |
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| author | Cosetta Bertoli Robertus A.M. de Bruin |
| author_facet | Cosetta Bertoli Robertus A.M. de Bruin |
| author_sort | Cosetta Bertoli |
| collection | DOAJ |
| description | DNA replication capacity, the maximal amount of DNA a cell can synthesize at any given time during S phase, is controlled by E2F-dependent transcription. Controlling replication capacity limits the replication rate and provides a robust mechanism to keep replication fork speed within an optimal range whilst ensuring timely completion of genome duplication. |
| first_indexed | 2024-03-11T22:39:57Z |
| format | Article |
| id | doaj.art-7ce3dee73b0e4cee8ae2f40f870efe2a |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:39:57Z |
| publishDate | 2021-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-7ce3dee73b0e4cee8ae2f40f870efe2a2023-09-22T09:11:02ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562021-03-018210.1080/23723556.2020.18392941839294Control of S phase duration: a replication capacity model with E2F transcription at its heartCosetta Bertoli0Robertus A.M. de Bruin1University College London, London, UKUniversity College London, London, UKDNA replication capacity, the maximal amount of DNA a cell can synthesize at any given time during S phase, is controlled by E2F-dependent transcription. Controlling replication capacity limits the replication rate and provides a robust mechanism to keep replication fork speed within an optimal range whilst ensuring timely completion of genome duplication.http://dx.doi.org/10.1080/23723556.2020.1839294dna replications phasedna replication capacitye2f-dependent transcriptiongenome stability |
| spellingShingle | Cosetta Bertoli Robertus A.M. de Bruin Control of S phase duration: a replication capacity model with E2F transcription at its heart Molecular & Cellular Oncology dna replication s phase dna replication capacity e2f-dependent transcription genome stability |
| title | Control of S phase duration: a replication capacity model with E2F transcription at its heart |
| title_full | Control of S phase duration: a replication capacity model with E2F transcription at its heart |
| title_fullStr | Control of S phase duration: a replication capacity model with E2F transcription at its heart |
| title_full_unstemmed | Control of S phase duration: a replication capacity model with E2F transcription at its heart |
| title_short | Control of S phase duration: a replication capacity model with E2F transcription at its heart |
| title_sort | control of s phase duration a replication capacity model with e2f transcription at its heart |
| topic | dna replication s phase dna replication capacity e2f-dependent transcription genome stability |
| url | http://dx.doi.org/10.1080/23723556.2020.1839294 |
| work_keys_str_mv | AT cosettabertoli controlofsphasedurationareplicationcapacitymodelwithe2ftranscriptionatitsheart AT robertusamdebruin controlofsphasedurationareplicationcapacitymodelwithe2ftranscriptionatitsheart |