Bacteriological profile and antibiotic susceptibility patterns in neonatal septicemia in view of emerging drug resistance
The objective of this study was to isolate pathogenic bacteria in neo-natal septicaemia cases, and to know their antibiograms. Under aseptic precautions, blood was drawn from 140 neonates with sus-pected septicaemia and inoculated in brain heart infusion (BHI) broth. Isolates obtained were identifie...
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| Format: | Article |
| Language: | English |
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Deccan College of Medical Sciences
2014-02-01
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| Series: | Journal of Medical and Allied Sciences |
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| Online Access: | http://jmas.in/Vol4Issue1/Bacteriological%20profile%20and%20antibiotic%20susceptibility%20patterns%20in%20neonatal%20septicemia%20in%20view%20of%20emerging%20drug%20resistance.pdf |
| _version_ | 1811261440951058432 |
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| author | Maimoona Mustafa Syed Laeeq Ahmed |
| author_facet | Maimoona Mustafa Syed Laeeq Ahmed |
| author_sort | Maimoona Mustafa |
| collection | DOAJ |
| description | The objective of this study was to isolate pathogenic bacteria in neo-natal septicaemia cases, and to know their antibiograms. Under aseptic precautions, blood was drawn from 140 neonates with sus-pected septicaemia and inoculated in brain heart infusion (BHI) broth. Isolates obtained were identified as per standard protocol and antibi-otic susceptibility was done by Kirby Bauer disc diffusion method (as per CLSI guidelines). A total number of 62 (44.2%) patients had positive blood cultures. The most common pathogens isolated were Klebsiella pneumoniae (n=22, 35%) followed by Staphylococcus aureus (n=15, 24.1%), Escherichia coli (n=14, 22.5%), CONS (n=7, 11.2%) and Pseudomonas aeruginosa (n=4, 6.4%). The Gram nega-tive organisms showed high resistance to commonly used antibiotics and were highly sensitive to Meropenem. The Gram positive bacteria showed high resistance to Ampicillin, Erythromycin and Amoxycillin; but they were highly susceptible to Linizolid and Vancomycin. As the Gram negative organisms were the most common isolates in neona-tal septicemia, their resistance pattern should be considered essen-tial for deciding the empirical treatment. Prompt treatment of neonatal sepsis with judicious use of appropriate antibiotics can minimize the morbidity and mortality, besides reducing the emergence of multi-drug resistant organisms in intensive care units (ICUs). |
| first_indexed | 2024-04-12T19:04:24Z |
| format | Article |
| id | doaj.art-7ce4bfde30b4436d90fa97cce8013404 |
| institution | Directory Open Access Journal |
| issn | 2231-1696 2231-170X |
| language | English |
| last_indexed | 2024-04-12T19:04:24Z |
| publishDate | 2014-02-01 |
| publisher | Deccan College of Medical Sciences |
| record_format | Article |
| series | Journal of Medical and Allied Sciences |
| spelling | doaj.art-7ce4bfde30b4436d90fa97cce80134042022-12-22T03:20:04ZengDeccan College of Medical SciencesJournal of Medical and Allied Sciences2231-16962231-170X2014-02-01410208Bacteriological profile and antibiotic susceptibility patterns in neonatal septicemia in view of emerging drug resistanceMaimoona Mustafa0Syed Laeeq Ahmed1Deccan College of Medical SciencesDeccan College of Medical SciencesThe objective of this study was to isolate pathogenic bacteria in neo-natal septicaemia cases, and to know their antibiograms. Under aseptic precautions, blood was drawn from 140 neonates with sus-pected septicaemia and inoculated in brain heart infusion (BHI) broth. Isolates obtained were identified as per standard protocol and antibi-otic susceptibility was done by Kirby Bauer disc diffusion method (as per CLSI guidelines). A total number of 62 (44.2%) patients had positive blood cultures. The most common pathogens isolated were Klebsiella pneumoniae (n=22, 35%) followed by Staphylococcus aureus (n=15, 24.1%), Escherichia coli (n=14, 22.5%), CONS (n=7, 11.2%) and Pseudomonas aeruginosa (n=4, 6.4%). The Gram nega-tive organisms showed high resistance to commonly used antibiotics and were highly sensitive to Meropenem. The Gram positive bacteria showed high resistance to Ampicillin, Erythromycin and Amoxycillin; but they were highly susceptible to Linizolid and Vancomycin. As the Gram negative organisms were the most common isolates in neona-tal septicemia, their resistance pattern should be considered essen-tial for deciding the empirical treatment. Prompt treatment of neonatal sepsis with judicious use of appropriate antibiotics can minimize the morbidity and mortality, besides reducing the emergence of multi-drug resistant organisms in intensive care units (ICUs).http://jmas.in/Vol4Issue1/Bacteriological%20profile%20and%20antibiotic%20susceptibility%20patterns%20in%20neonatal%20septicemia%20in%20view%20of%20emerging%20drug%20resistance.pdfcoagulase negative Staphylococcus (CONS)drug susceptibilityearly onset septicemialate onset septicemianeonatal septicemia |
| spellingShingle | Maimoona Mustafa Syed Laeeq Ahmed Bacteriological profile and antibiotic susceptibility patterns in neonatal septicemia in view of emerging drug resistance Journal of Medical and Allied Sciences coagulase negative Staphylococcus (CONS) drug susceptibility early onset septicemia late onset septicemia neonatal septicemia |
| title | Bacteriological profile and antibiotic susceptibility patterns in neonatal septicemia in view of emerging drug resistance |
| title_full | Bacteriological profile and antibiotic susceptibility patterns in neonatal septicemia in view of emerging drug resistance |
| title_fullStr | Bacteriological profile and antibiotic susceptibility patterns in neonatal septicemia in view of emerging drug resistance |
| title_full_unstemmed | Bacteriological profile and antibiotic susceptibility patterns in neonatal septicemia in view of emerging drug resistance |
| title_short | Bacteriological profile and antibiotic susceptibility patterns in neonatal septicemia in view of emerging drug resistance |
| title_sort | bacteriological profile and antibiotic susceptibility patterns in neonatal septicemia in view of emerging drug resistance |
| topic | coagulase negative Staphylococcus (CONS) drug susceptibility early onset septicemia late onset septicemia neonatal septicemia |
| url | http://jmas.in/Vol4Issue1/Bacteriological%20profile%20and%20antibiotic%20susceptibility%20patterns%20in%20neonatal%20septicemia%20in%20view%20of%20emerging%20drug%20resistance.pdf |
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