Is Topical Application of Hyaluronic Acid in Oral Lichen Planus Effective? A Randomized Controlled Crossover Study
Hyaluronic acid (HA) has anti-inflammatory and anti-edematous effects and, thus, could be promising in the treatment of oral lichen planus (OLP). The aim of the study was to evaluate the effects of topical hyaluronic acid, compared to placebo, on salivary levels of calprotectin, interleukin-6 (IL-6)...
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MDPI AG
2020-11-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/10/22/7988 |
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| author | Corinna Bruckmann Rudolf Seemann Klemens Rappersberger Xiaohui Rausch-Fan Hady Haririan Gabriella Dvorak |
| author_facet | Corinna Bruckmann Rudolf Seemann Klemens Rappersberger Xiaohui Rausch-Fan Hady Haririan Gabriella Dvorak |
| author_sort | Corinna Bruckmann |
| collection | DOAJ |
| description | Hyaluronic acid (HA) has anti-inflammatory and anti-edematous effects and, thus, could be promising in the treatment of oral lichen planus (OLP). The aim of the study was to evaluate the effects of topical hyaluronic acid, compared to placebo, on salivary levels of calprotectin, interleukin-6 (IL-6), and bacteria, as well as clinical and subjective parameters. Fourteen patients with confirmed OLP were included. After random selection, patients started with either 0.2% hyaluronic acid or a placebo gel for 6 weeks. Following a wash-out period, the groups changed the application. Whole saliva, clinical parameters, and questionnaires were evaluated before and after the intervention, as well as after the crossover phase. Salivary calprotectin, IL-6, and inflammation-related bacteria were determined by ELISA and PCR, respectively. There were no significant differences in clinical or subjective outcome parameters, salivary levels of IL-6, calprotectin, or bacteria after the application of hyaluronic acid, compared to placebo. However, only nine patients completed the study, as five out of seven patients starting with placebo were lost to follow-up. Significant effects of HA on inflammatory mediators and clinical parameters in OLP patients could not be proven, although a trend in clinical severity improvement could be observed. |
| first_indexed | 2024-03-10T14:56:57Z |
| format | Article |
| id | doaj.art-7ce626a3c68e4ee799f0905650c749fb |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T14:56:57Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-7ce626a3c68e4ee799f0905650c749fb2023-11-20T20:31:20ZengMDPI AGApplied Sciences2076-34172020-11-011022798810.3390/app10227988Is Topical Application of Hyaluronic Acid in Oral Lichen Planus Effective? A Randomized Controlled Crossover StudyCorinna Bruckmann0Rudolf Seemann1Klemens Rappersberger2Xiaohui Rausch-Fan3Hady Haririan4Gabriella Dvorak5Division of Conservative Dentistry and Periodontology, University Clinic of Dentistry, Medical University of Vienna, 1090 Vienna, AustriaEvangelic Hospital Vienna, 1180 Vienna, AustriaDepartment of Dermatology, KH Rudolfstiftung, KAV Vienna, 1030 Vienna, AustriaDivision of Conservative Dentistry and Periodontology, University Clinic of Dentistry, Medical University of Vienna, 1090 Vienna, AustriaDivision of Conservative Dentistry and Periodontology, University Clinic of Dentistry, Medical University of Vienna, 1090 Vienna, AustriaDivision of Conservative Dentistry and Periodontology, University Clinic of Dentistry, Medical University of Vienna, 1090 Vienna, AustriaHyaluronic acid (HA) has anti-inflammatory and anti-edematous effects and, thus, could be promising in the treatment of oral lichen planus (OLP). The aim of the study was to evaluate the effects of topical hyaluronic acid, compared to placebo, on salivary levels of calprotectin, interleukin-6 (IL-6), and bacteria, as well as clinical and subjective parameters. Fourteen patients with confirmed OLP were included. After random selection, patients started with either 0.2% hyaluronic acid or a placebo gel for 6 weeks. Following a wash-out period, the groups changed the application. Whole saliva, clinical parameters, and questionnaires were evaluated before and after the intervention, as well as after the crossover phase. Salivary calprotectin, IL-6, and inflammation-related bacteria were determined by ELISA and PCR, respectively. There were no significant differences in clinical or subjective outcome parameters, salivary levels of IL-6, calprotectin, or bacteria after the application of hyaluronic acid, compared to placebo. However, only nine patients completed the study, as five out of seven patients starting with placebo were lost to follow-up. Significant effects of HA on inflammatory mediators and clinical parameters in OLP patients could not be proven, although a trend in clinical severity improvement could be observed.https://www.mdpi.com/2076-3417/10/22/7988salivary markersOLPHAinterleukin-6calprotectinsaliva |
| spellingShingle | Corinna Bruckmann Rudolf Seemann Klemens Rappersberger Xiaohui Rausch-Fan Hady Haririan Gabriella Dvorak Is Topical Application of Hyaluronic Acid in Oral Lichen Planus Effective? A Randomized Controlled Crossover Study Applied Sciences salivary markers OLP HA interleukin-6 calprotectin saliva |
| title | Is Topical Application of Hyaluronic Acid in Oral Lichen Planus Effective? A Randomized Controlled Crossover Study |
| title_full | Is Topical Application of Hyaluronic Acid in Oral Lichen Planus Effective? A Randomized Controlled Crossover Study |
| title_fullStr | Is Topical Application of Hyaluronic Acid in Oral Lichen Planus Effective? A Randomized Controlled Crossover Study |
| title_full_unstemmed | Is Topical Application of Hyaluronic Acid in Oral Lichen Planus Effective? A Randomized Controlled Crossover Study |
| title_short | Is Topical Application of Hyaluronic Acid in Oral Lichen Planus Effective? A Randomized Controlled Crossover Study |
| title_sort | is topical application of hyaluronic acid in oral lichen planus effective a randomized controlled crossover study |
| topic | salivary markers OLP HA interleukin-6 calprotectin saliva |
| url | https://www.mdpi.com/2076-3417/10/22/7988 |
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