Aconitine and its derivatives: bioactivities, structure-activity relationships and preliminary molecular mechanisms
Aconitine (AC), which is the primary bioactive diterpene alkaloid derived from Aconitum L plants, have attracted considerable interest due to its unique structural feature. Additionally, AC demonstrates a range of biological activities, such as its ability to enhance cardiac function, inhibit tumor...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2024.1339364/full |
| _version_ | 1797349441144881152 |
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| author | Pengyu Zhao Ye Tian Yuefei Geng Chenjuan Zeng Xiuying Ma Jie Kang Lin Lu Xin Zhang Bo Tang Funeng Geng Funeng Geng |
| author_facet | Pengyu Zhao Ye Tian Yuefei Geng Chenjuan Zeng Xiuying Ma Jie Kang Lin Lu Xin Zhang Bo Tang Funeng Geng Funeng Geng |
| author_sort | Pengyu Zhao |
| collection | DOAJ |
| description | Aconitine (AC), which is the primary bioactive diterpene alkaloid derived from Aconitum L plants, have attracted considerable interest due to its unique structural feature. Additionally, AC demonstrates a range of biological activities, such as its ability to enhance cardiac function, inhibit tumor growth, reduce inflammation, and provide analgesic effects. However, the structure-activity relationships of AC are remain unclear. A clear understanding of these relationships is indeed critical in developing effective biomedical applications with AC. In line with these challenges, this paper summarized the structural characteristics of AC and relevant functional and bioactive properties and the structure-activity relationships presented in biomedical applications. The primary temporal scope of this review was established as the period spanning from 2010 to 2023. Subsequently, the objective of this review was to provide a comprehensive understanding of the specific action mechanism of AC, while also exploring potential novel applications of AC derivatives in the biomedical field, drawing upon their structural characteristics. In conclusion, this review has provided a comprehensive analysis of the challenges and prospects associated with AC in the elucidation of structure-bioactivity relationships. Furthermore, the importance of exploring modern biotechnology approaches to enhance the potential biomedical applications of AC has been emphasized. |
| first_indexed | 2024-03-08T12:30:17Z |
| format | Article |
| id | doaj.art-7ce7b6a3f71848498982d6a6a9b16f9e |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-03-08T12:30:17Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-7ce7b6a3f71848498982d6a6a9b16f9e2024-01-22T04:39:29ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462024-01-011210.3389/fchem.2024.13393641339364Aconitine and its derivatives: bioactivities, structure-activity relationships and preliminary molecular mechanismsPengyu Zhao0Ye Tian1Yuefei Geng2Chenjuan Zeng3Xiuying Ma4Jie Kang5Lin Lu6Xin Zhang7Bo Tang8Funeng Geng9Funeng Geng10School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaGuizhou Yunfeng Pharmaceutical Co., Ltd., Qianxinan Buyi and Miao Autonomous Prefecture, ChinaSichuan Key Laboratory of Medical American Cockroach, Chengdu, ChinaGuizhou Yunfeng Pharmaceutical Co., Ltd., Qianxinan Buyi and Miao Autonomous Prefecture, ChinaSichuan Key Laboratory of Medical American Cockroach, Chengdu, ChinaGuizhou Yunfeng Pharmaceutical Co., Ltd., Qianxinan Buyi and Miao Autonomous Prefecture, ChinaSichuan Engineering Research Center for Medicinal Animals, Chengdu, ChinaSichuan Good Doctor Pharmaceutical Group, Chengdu, ChinaSichuan Engineering Research Center for Medicinal Animals, Chengdu, ChinaSichuan Key Laboratory of Medical American Cockroach, Chengdu, ChinaChengdu University of Traditional Chinese Medicine, Chengdu, ChinaAconitine (AC), which is the primary bioactive diterpene alkaloid derived from Aconitum L plants, have attracted considerable interest due to its unique structural feature. Additionally, AC demonstrates a range of biological activities, such as its ability to enhance cardiac function, inhibit tumor growth, reduce inflammation, and provide analgesic effects. However, the structure-activity relationships of AC are remain unclear. A clear understanding of these relationships is indeed critical in developing effective biomedical applications with AC. In line with these challenges, this paper summarized the structural characteristics of AC and relevant functional and bioactive properties and the structure-activity relationships presented in biomedical applications. The primary temporal scope of this review was established as the period spanning from 2010 to 2023. Subsequently, the objective of this review was to provide a comprehensive understanding of the specific action mechanism of AC, while also exploring potential novel applications of AC derivatives in the biomedical field, drawing upon their structural characteristics. In conclusion, this review has provided a comprehensive analysis of the challenges and prospects associated with AC in the elucidation of structure-bioactivity relationships. Furthermore, the importance of exploring modern biotechnology approaches to enhance the potential biomedical applications of AC has been emphasized.https://www.frontiersin.org/articles/10.3389/fchem.2024.1339364/fullAconitinebiological activitiesstructure-activity relationshipsmolecular mechanismditerpenoid alkaloids |
| spellingShingle | Pengyu Zhao Ye Tian Yuefei Geng Chenjuan Zeng Xiuying Ma Jie Kang Lin Lu Xin Zhang Bo Tang Funeng Geng Funeng Geng Aconitine and its derivatives: bioactivities, structure-activity relationships and preliminary molecular mechanisms Frontiers in Chemistry Aconitine biological activities structure-activity relationships molecular mechanism diterpenoid alkaloids |
| title | Aconitine and its derivatives: bioactivities, structure-activity relationships and preliminary molecular mechanisms |
| title_full | Aconitine and its derivatives: bioactivities, structure-activity relationships and preliminary molecular mechanisms |
| title_fullStr | Aconitine and its derivatives: bioactivities, structure-activity relationships and preliminary molecular mechanisms |
| title_full_unstemmed | Aconitine and its derivatives: bioactivities, structure-activity relationships and preliminary molecular mechanisms |
| title_short | Aconitine and its derivatives: bioactivities, structure-activity relationships and preliminary molecular mechanisms |
| title_sort | aconitine and its derivatives bioactivities structure activity relationships and preliminary molecular mechanisms |
| topic | Aconitine biological activities structure-activity relationships molecular mechanism diterpenoid alkaloids |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2024.1339364/full |
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