Local heterogeneity of normal lung parenchyma and small airways disease are associated with COPD severity and progression

Local heterogeneity of normal lung parenchyma and small airways disease are associated with COPD severity and progression

Abstract Background Small airways disease (SAD) is a major cause of airflow obstruction in COPD patients and has been identified as a precursor to emphysema. Although the amount of SAD in the lungs can be quantified using our Parametric Response Mapping (PRM) approach, the full breadth of this reado...

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Bibliographic Details
Main Authors: Alexander J. Bell, Ravi Pal, Wassim W. Labaki, Benjamin A. Hoff, Jennifer M. Wang, Susan Murray, Ella A. Kazerooni, Stefanie Galban, David A. Lynch, Stephen M. Humphries, Fernando J. Martinez, Charles R. Hatt, MeiLan K. Han, Sundaresh Ram, Craig J. Galban
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Respiratory Research
Subjects:
Chronic obstructive pulmonary disease
Small airways disease
Parametric response mapping
Computed tomography of the chest
Machine learning
Emphysema
Online Access:https://doi.org/10.1186/s12931-024-02729-x

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