MicroRNAs as Theranostics Targets in Oral Carcinoma Stem Cells
Oral cancer belongs to head and neck squamous cell carcinoma and has been recognized as one of the most prevalent malignancies worldwide. Recent studies have suggested that cancer stem cells (CSCs) may participate in tumor initiation, metastasis and even recurrence, so the regulation of CSCs has dra...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/2/340 |
| _version_ | 1797709210405830656 |
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| author | Pei-Ling Hsieh Yi-Wen Liao Martin Pichler Cheng-Chia Yu |
| author_facet | Pei-Ling Hsieh Yi-Wen Liao Martin Pichler Cheng-Chia Yu |
| author_sort | Pei-Ling Hsieh |
| collection | DOAJ |
| description | Oral cancer belongs to head and neck squamous cell carcinoma and has been recognized as one of the most prevalent malignancies worldwide. Recent studies have suggested that cancer stem cells (CSCs) may participate in tumor initiation, metastasis and even recurrence, so the regulation of CSCs has drawn significant attention over the past decade. Among various molecules that are associated with CSCs, non-coding RNAs (ncRNAs) have been indicated as key players in the acquisition and maintenance of cancer stemness. In addition, accumulating studies have shown that the aberrant expression of these ncRNAs may serve as surrogate diagnostic markers or even therapeutic targets for cancer treatment. The current study reviews the previous work by us and others to summarize how these ncRNAs affect oral cancer stemness and their potential theranostic applications. A better understanding of the implication of these ncRNAs in oral tumorigenesis will facilitate the translation of basic ncRNA research into clinical application in the future. |
| first_indexed | 2024-03-12T06:33:03Z |
| format | Article |
| id | doaj.art-7ce866bc5b684f749a27e91bfe5c2135 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T06:33:03Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-7ce866bc5b684f749a27e91bfe5c21352023-09-03T01:29:56ZengMDPI AGCancers2072-66942020-02-0112234010.3390/cancers12020340cancers12020340MicroRNAs as Theranostics Targets in Oral Carcinoma Stem CellsPei-Ling Hsieh0Yi-Wen Liao1Martin Pichler2Cheng-Chia Yu3Department of Anatomy, School of Medicine, China Medical University, Taichung 404, TaiwanSchool of Dentistry, Chung Shan Medical University, Taichung 40201, TaiwanResearch Unit of Non-Coding RNAs and Genome Editing, Division of Clinical Oncology, Department of Medicine, Comprehensive Cancer Center Graz, Medical University of Graz, 8036 Graz, AustriaSchool of Dentistry, Chung Shan Medical University, Taichung 40201, TaiwanOral cancer belongs to head and neck squamous cell carcinoma and has been recognized as one of the most prevalent malignancies worldwide. Recent studies have suggested that cancer stem cells (CSCs) may participate in tumor initiation, metastasis and even recurrence, so the regulation of CSCs has drawn significant attention over the past decade. Among various molecules that are associated with CSCs, non-coding RNAs (ncRNAs) have been indicated as key players in the acquisition and maintenance of cancer stemness. In addition, accumulating studies have shown that the aberrant expression of these ncRNAs may serve as surrogate diagnostic markers or even therapeutic targets for cancer treatment. The current study reviews the previous work by us and others to summarize how these ncRNAs affect oral cancer stemness and their potential theranostic applications. A better understanding of the implication of these ncRNAs in oral tumorigenesis will facilitate the translation of basic ncRNA research into clinical application in the future.https://www.mdpi.com/2072-6694/12/2/340head and neck squamous cell carcinomaoral cancercancer stem cellsnon-coding rnas |
| spellingShingle | Pei-Ling Hsieh Yi-Wen Liao Martin Pichler Cheng-Chia Yu MicroRNAs as Theranostics Targets in Oral Carcinoma Stem Cells Cancers head and neck squamous cell carcinoma oral cancer cancer stem cells non-coding rnas |
| title | MicroRNAs as Theranostics Targets in Oral Carcinoma Stem Cells |
| title_full | MicroRNAs as Theranostics Targets in Oral Carcinoma Stem Cells |
| title_fullStr | MicroRNAs as Theranostics Targets in Oral Carcinoma Stem Cells |
| title_full_unstemmed | MicroRNAs as Theranostics Targets in Oral Carcinoma Stem Cells |
| title_short | MicroRNAs as Theranostics Targets in Oral Carcinoma Stem Cells |
| title_sort | micrornas as theranostics targets in oral carcinoma stem cells |
| topic | head and neck squamous cell carcinoma oral cancer cancer stem cells non-coding rnas |
| url | https://www.mdpi.com/2072-6694/12/2/340 |
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