Nonlinear Relationship Between Interleukin-6 and NT-proBNP at Admission in Hospitalized COVID-19 Patients
Meijuan Zhang, Zhanquan Jiao Department of Cardiology, Tianjin Institute of Respiratory Diseases, Tianjin Haihe Hospital, Tianjin University, Tianjin, People’s Republic of ChinaCorrespondence: Zhanquan Jiao, Department of Cardiology, Tianjin Haihe Hospital, Jingu Road, Tianjin, 300350, People’s Repu...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-09-01
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| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/nonlinear-relationship-between-interleukin-6-and-nt-probnp-at-admissio-peer-reviewed-fulltext-article-IDR |
| _version_ | 1797678097475043328 |
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| author | Zhang M Jiao Z |
| author_facet | Zhang M Jiao Z |
| author_sort | Zhang M |
| collection | DOAJ |
| description | Meijuan Zhang, Zhanquan Jiao Department of Cardiology, Tianjin Institute of Respiratory Diseases, Tianjin Haihe Hospital, Tianjin University, Tianjin, People’s Republic of ChinaCorrespondence: Zhanquan Jiao, Department of Cardiology, Tianjin Haihe Hospital, Jingu Road, Tianjin, 300350, People’s Republic of China, Tel +8613752370120, Email jiaozhanquan@126.comPurpose: Elevated levels of the inflammatory marker interleukin-6 (IL-6) and cardiac injury marker N-terminal pro-B-type natriuretic peptide (NT-proBNP) have been observed in patients with coronavirus disease 2019 (COVID-19). However, the relationship between IL-6 and NT-proBNP levels remains unclear. Therefore, we investigated the relationship between IL-6 and NT-proBNP levels in patients with COVID-19.Patients and Methods: This was a cross-sectional study. Consecutive patients with COVID-19 were included herein. The independent and dependent target variables were the IL-6 and NT-proBNP levels, respectively, measured at baseline. Univariate and multivariate linear regression analyses and curve fitting were also performed.Results: The average age of the 121 selected participants was 49.8 ± 15.8 years old, and 48.8% (59/121) were male. The estimated β value between Ln-transformed IL-6 and NT-proBNP was 0.28 (95% confidence interval [CI] 0.12– 0.44, P = 0.001) in univariate logistic regression analysis and 0.09 (95% CI − 0.04– 0.21, P = 0.176) in the fully adjusted model. This relationship was nonlinear, with a point of 2.7, and the β values (and CIs) for the left (< 2.7) and right (≥ 2.7) sides of the inflection point were − 0.06 (95% CI − 0.23– 0.12, P = 0.534) and 0.77 (95% CI 0.18– 1.37, P = 0.016) in the fully adjusted model, respectively.Conclusion: Our results suggest a nonlinear association between IL-6 and NT-proBNP levels. Higher IL-6 levels are associated with NT-proBNP in patients with COVID-19.Keywords: interleukin-6, NT-proBNP, COVID-19, nonlinear association |
| first_indexed | 2024-03-11T22:54:05Z |
| format | Article |
| id | doaj.art-7cea1ce7f71c452f8320107b99909ecc |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-03-11T22:54:05Z |
| publishDate | 2023-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-7cea1ce7f71c452f8320107b99909ecc2023-09-21T19:09:00ZengDove Medical PressInfection and Drug Resistance1178-69732023-09-01Volume 166259626786864Nonlinear Relationship Between Interleukin-6 and NT-proBNP at Admission in Hospitalized COVID-19 PatientsZhang MJiao ZMeijuan Zhang, Zhanquan Jiao Department of Cardiology, Tianjin Institute of Respiratory Diseases, Tianjin Haihe Hospital, Tianjin University, Tianjin, People’s Republic of ChinaCorrespondence: Zhanquan Jiao, Department of Cardiology, Tianjin Haihe Hospital, Jingu Road, Tianjin, 300350, People’s Republic of China, Tel +8613752370120, Email jiaozhanquan@126.comPurpose: Elevated levels of the inflammatory marker interleukin-6 (IL-6) and cardiac injury marker N-terminal pro-B-type natriuretic peptide (NT-proBNP) have been observed in patients with coronavirus disease 2019 (COVID-19). However, the relationship between IL-6 and NT-proBNP levels remains unclear. Therefore, we investigated the relationship between IL-6 and NT-proBNP levels in patients with COVID-19.Patients and Methods: This was a cross-sectional study. Consecutive patients with COVID-19 were included herein. The independent and dependent target variables were the IL-6 and NT-proBNP levels, respectively, measured at baseline. Univariate and multivariate linear regression analyses and curve fitting were also performed.Results: The average age of the 121 selected participants was 49.8 ± 15.8 years old, and 48.8% (59/121) were male. The estimated β value between Ln-transformed IL-6 and NT-proBNP was 0.28 (95% confidence interval [CI] 0.12– 0.44, P = 0.001) in univariate logistic regression analysis and 0.09 (95% CI − 0.04– 0.21, P = 0.176) in the fully adjusted model. This relationship was nonlinear, with a point of 2.7, and the β values (and CIs) for the left (< 2.7) and right (≥ 2.7) sides of the inflection point were − 0.06 (95% CI − 0.23– 0.12, P = 0.534) and 0.77 (95% CI 0.18– 1.37, P = 0.016) in the fully adjusted model, respectively.Conclusion: Our results suggest a nonlinear association between IL-6 and NT-proBNP levels. Higher IL-6 levels are associated with NT-proBNP in patients with COVID-19.Keywords: interleukin-6, NT-proBNP, COVID-19, nonlinear associationhttps://www.dovepress.com/nonlinear-relationship-between-interleukin-6-and-nt-probnp-at-admissio-peer-reviewed-fulltext-article-IDRinterleukin-6nt-probnpcovid-19nonlinear associationsubgroup analysis |
| spellingShingle | Zhang M Jiao Z Nonlinear Relationship Between Interleukin-6 and NT-proBNP at Admission in Hospitalized COVID-19 Patients Infection and Drug Resistance interleukin-6 nt-probnp covid-19 nonlinear association subgroup analysis |
| title | Nonlinear Relationship Between Interleukin-6 and NT-proBNP at Admission in Hospitalized COVID-19 Patients |
| title_full | Nonlinear Relationship Between Interleukin-6 and NT-proBNP at Admission in Hospitalized COVID-19 Patients |
| title_fullStr | Nonlinear Relationship Between Interleukin-6 and NT-proBNP at Admission in Hospitalized COVID-19 Patients |
| title_full_unstemmed | Nonlinear Relationship Between Interleukin-6 and NT-proBNP at Admission in Hospitalized COVID-19 Patients |
| title_short | Nonlinear Relationship Between Interleukin-6 and NT-proBNP at Admission in Hospitalized COVID-19 Patients |
| title_sort | nonlinear relationship between interleukin 6 and nt probnp at admission in hospitalized covid 19 patients |
| topic | interleukin-6 nt-probnp covid-19 nonlinear association subgroup analysis |
| url | https://www.dovepress.com/nonlinear-relationship-between-interleukin-6-and-nt-probnp-at-admissio-peer-reviewed-fulltext-article-IDR |
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