The molecular pathogenesis of triptolide-induced hepatotoxicity
Triptolide (TP) is the major pharmacologically active ingredient and toxic component of Tripterygium wilfordii Hook. f. However, its clinical potential is limited by a narrow therapeutic window and multiple organ toxicity, especially hepatotoxicity. Furthermore, TP-induced hepatotoxicity shows signi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.979307/full |
| _version_ | 1798037045396897792 |
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| author | Yeqing Hu Yeqing Hu Yeqing Hu Qiguo Wu Yulin Wang Yulin Wang Yulin Wang Haibo Zhang Haibo Zhang Haibo Zhang Xueying Liu Xueying Liu Xueying Liu Hua Zhou Hua Zhou Hua Zhou Tao Yang Tao Yang Tao Yang Tao Yang |
| author_facet | Yeqing Hu Yeqing Hu Yeqing Hu Qiguo Wu Yulin Wang Yulin Wang Yulin Wang Haibo Zhang Haibo Zhang Haibo Zhang Xueying Liu Xueying Liu Xueying Liu Hua Zhou Hua Zhou Hua Zhou Tao Yang Tao Yang Tao Yang Tao Yang |
| author_sort | Yeqing Hu |
| collection | DOAJ |
| description | Triptolide (TP) is the major pharmacologically active ingredient and toxic component of Tripterygium wilfordii Hook. f. However, its clinical potential is limited by a narrow therapeutic window and multiple organ toxicity, especially hepatotoxicity. Furthermore, TP-induced hepatotoxicity shows significant inter-individual variability. Over the past few decades, research has been devoted to the study of TP-induced hepatotoxicity and its mechanism. In this review, we summarized the mechanism of TP-induced hepatotoxicity. Studies have demonstrated that TP-induced hepatotoxicity is associated with CYP450s, P-glycoprotein (P-gp), oxidative stress, excessive autophagy, apoptosis, metabolic disorders, immunity, and the gut microbiota. These new findings provide a comprehensive understanding of TP-induced hepatotoxicity and detoxification. |
| first_indexed | 2024-04-11T21:21:00Z |
| format | Article |
| id | doaj.art-7cea825fdc224a569fed9b7770b6ebb4 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T21:21:00Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-7cea825fdc224a569fed9b7770b6ebb42022-12-22T04:02:37ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-08-011310.3389/fphar.2022.979307979307The molecular pathogenesis of triptolide-induced hepatotoxicityYeqing Hu0Yeqing Hu1Yeqing Hu2Qiguo Wu3Yulin Wang4Yulin Wang5Yulin Wang6Haibo Zhang7Haibo Zhang8Haibo Zhang9Xueying Liu10Xueying Liu11Xueying Liu12Hua Zhou13Hua Zhou14Hua Zhou15Tao Yang16Tao Yang17Tao Yang18Tao Yang19Institute of Cardiovascular Disease, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Cardiovascular Disease of Integrated Traditional Chinese Medicine and Western Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaShuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Branch of National Clinical Research Center for Chinese Medicine Cardiology, Shanghai, ChinaDepartment of Pharmacy, Anqing Medical College, Anqing, ChinaInstitute of Cardiovascular Disease, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Cardiovascular Disease of Integrated Traditional Chinese Medicine and Western Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaShuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Branch of National Clinical Research Center for Chinese Medicine Cardiology, Shanghai, ChinaInstitute of Cardiovascular Disease, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Cardiovascular Disease of Integrated Traditional Chinese Medicine and Western Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaShuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Branch of National Clinical Research Center for Chinese Medicine Cardiology, Shanghai, ChinaInstitute of Cardiovascular Disease, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Cardiovascular Disease of Integrated Traditional Chinese Medicine and Western Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaShuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Branch of National Clinical Research Center for Chinese Medicine Cardiology, Shanghai, ChinaInstitute of Cardiovascular Disease, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Cardiovascular Disease of Integrated Traditional Chinese Medicine and Western Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaShuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Branch of National Clinical Research Center for Chinese Medicine Cardiology, Shanghai, ChinaInstitute of Cardiovascular Disease, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Cardiovascular Disease of Integrated Traditional Chinese Medicine and Western Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaShuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Branch of National Clinical Research Center for Chinese Medicine Cardiology, Shanghai, ChinaShanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai, ChinaTriptolide (TP) is the major pharmacologically active ingredient and toxic component of Tripterygium wilfordii Hook. f. However, its clinical potential is limited by a narrow therapeutic window and multiple organ toxicity, especially hepatotoxicity. Furthermore, TP-induced hepatotoxicity shows significant inter-individual variability. Over the past few decades, research has been devoted to the study of TP-induced hepatotoxicity and its mechanism. In this review, we summarized the mechanism of TP-induced hepatotoxicity. Studies have demonstrated that TP-induced hepatotoxicity is associated with CYP450s, P-glycoprotein (P-gp), oxidative stress, excessive autophagy, apoptosis, metabolic disorders, immunity, and the gut microbiota. These new findings provide a comprehensive understanding of TP-induced hepatotoxicity and detoxification.https://www.frontiersin.org/articles/10.3389/fphar.2022.979307/fulltriptolidehepatotoxicityCYP450soxidative stressimmunity |
| spellingShingle | Yeqing Hu Yeqing Hu Yeqing Hu Qiguo Wu Yulin Wang Yulin Wang Yulin Wang Haibo Zhang Haibo Zhang Haibo Zhang Xueying Liu Xueying Liu Xueying Liu Hua Zhou Hua Zhou Hua Zhou Tao Yang Tao Yang Tao Yang Tao Yang The molecular pathogenesis of triptolide-induced hepatotoxicity Frontiers in Pharmacology triptolide hepatotoxicity CYP450s oxidative stress immunity |
| title | The molecular pathogenesis of triptolide-induced hepatotoxicity |
| title_full | The molecular pathogenesis of triptolide-induced hepatotoxicity |
| title_fullStr | The molecular pathogenesis of triptolide-induced hepatotoxicity |
| title_full_unstemmed | The molecular pathogenesis of triptolide-induced hepatotoxicity |
| title_short | The molecular pathogenesis of triptolide-induced hepatotoxicity |
| title_sort | molecular pathogenesis of triptolide induced hepatotoxicity |
| topic | triptolide hepatotoxicity CYP450s oxidative stress immunity |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.979307/full |
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