Total serum immunoglobulin E in patients with alopecia areata
Context: Alopecia areata (AA) is a common form of localized, non-scarring hair loss. The pathogenesis of the disease is unknown. Previous evidence suggested the involvement of Th2 cytokines in disease pathogenesis. Aim: To determine serum level of total IgE, this is mainly influenced by Th2 cytokine...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Indian Dermatology Online Journal |
| Subjects: | |
| Online Access: | http://www.idoj.in/article.asp?issn=2229-5178;year=2014;volume=5;issue=2;spage=122;epage=127;aulast=Bakry |
| _version_ | 1818681411957161984 |
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| author | Ola Ahmed Bakry Rania Mohamed Azmy El Shazly Mohamed Ahmed Basha Hanan Mostafa |
| author_facet | Ola Ahmed Bakry Rania Mohamed Azmy El Shazly Mohamed Ahmed Basha Hanan Mostafa |
| author_sort | Ola Ahmed Bakry |
| collection | DOAJ |
| description | Context: Alopecia areata (AA) is a common form of localized, non-scarring hair loss. The pathogenesis of the disease is unknown. Previous evidence suggested the involvement of Th2 cytokines in disease pathogenesis. Aim: To determine serum level of total IgE, this is mainly influenced by Th2 cytokines, in Egyptian patients with AA. Materials and Methods: Fifty subjects with AA (28 males and 22 females) were selected from Dermatology Outpatient Clinic, Menoufiya University Hospital from February 2012 to December 2012. Subjects with other conditions that might elevate serum IgE were excluded from the study. Fifty age- and sex-matched healthy subjects were selected as a control group. Venous blood samples were taken from cases and controls for measurement of total serum IgE by enzyme-linked immunosorbent assay. Skin biopsy was taken from every case from an active area of hair loss. Results: Total serum IgE was elevated in 27 (54%) cases. Its values among patients ranged from 13.5 IU/ml to 780 IU/ml. There was a statistically significant difference between cases and controls with regard to mean value of serum IgE (P < 0.05). Mean value of IgE did not vary significantly with disease severity, patients′ age, patients′ gender, disease duration, site of lesions, and positive family history of AA. No correlation was found between serum IgE levels and histopathological changes detected in examined cases. Conclusions: Total serum IgE is elevated in AA. This elevation is not related to age, gender, disease duration, disease severity, site of affection or family history of AA. |
| first_indexed | 2024-12-17T10:02:32Z |
| format | Article |
| id | doaj.art-7cec1a4279024844a1a3d6290e1cbcf8 |
| institution | Directory Open Access Journal |
| issn | 2229-5178 |
| language | English |
| last_indexed | 2024-12-17T10:02:32Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Dermatology Online Journal |
| spelling | doaj.art-7cec1a4279024844a1a3d6290e1cbcf82022-12-21T21:53:16ZengWolters Kluwer Medknow PublicationsIndian Dermatology Online Journal2229-51782014-01-015212212710.4103/2229-5178.131076Total serum immunoglobulin E in patients with alopecia areataOla Ahmed BakryRania Mohamed Azmy El ShazlyMohamed Ahmed BashaHanan MostafaContext: Alopecia areata (AA) is a common form of localized, non-scarring hair loss. The pathogenesis of the disease is unknown. Previous evidence suggested the involvement of Th2 cytokines in disease pathogenesis. Aim: To determine serum level of total IgE, this is mainly influenced by Th2 cytokines, in Egyptian patients with AA. Materials and Methods: Fifty subjects with AA (28 males and 22 females) were selected from Dermatology Outpatient Clinic, Menoufiya University Hospital from February 2012 to December 2012. Subjects with other conditions that might elevate serum IgE were excluded from the study. Fifty age- and sex-matched healthy subjects were selected as a control group. Venous blood samples were taken from cases and controls for measurement of total serum IgE by enzyme-linked immunosorbent assay. Skin biopsy was taken from every case from an active area of hair loss. Results: Total serum IgE was elevated in 27 (54%) cases. Its values among patients ranged from 13.5 IU/ml to 780 IU/ml. There was a statistically significant difference between cases and controls with regard to mean value of serum IgE (P < 0.05). Mean value of IgE did not vary significantly with disease severity, patients′ age, patients′ gender, disease duration, site of lesions, and positive family history of AA. No correlation was found between serum IgE levels and histopathological changes detected in examined cases. Conclusions: Total serum IgE is elevated in AA. This elevation is not related to age, gender, disease duration, disease severity, site of affection or family history of AA.http://www.idoj.in/article.asp?issn=2229-5178;year=2014;volume=5;issue=2;spage=122;epage=127;aulast=BakryAlopeciaIgEpathogenesis |
| spellingShingle | Ola Ahmed Bakry Rania Mohamed Azmy El Shazly Mohamed Ahmed Basha Hanan Mostafa Total serum immunoglobulin E in patients with alopecia areata Indian Dermatology Online Journal Alopecia IgE pathogenesis |
| title | Total serum immunoglobulin E in patients with alopecia areata |
| title_full | Total serum immunoglobulin E in patients with alopecia areata |
| title_fullStr | Total serum immunoglobulin E in patients with alopecia areata |
| title_full_unstemmed | Total serum immunoglobulin E in patients with alopecia areata |
| title_short | Total serum immunoglobulin E in patients with alopecia areata |
| title_sort | total serum immunoglobulin e in patients with alopecia areata |
| topic | Alopecia IgE pathogenesis |
| url | http://www.idoj.in/article.asp?issn=2229-5178;year=2014;volume=5;issue=2;spage=122;epage=127;aulast=Bakry |
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