Papillary muscle approximation reduces systolic tethering forces and improves mitral valve closure in the repair of functional mitral regurgitationCentral MessagePerspective
Background: Undersizing mitral annuloplasty (UMA) to repair functional mitral regurgitation (FMR) lacks durability, as it forces leaflet coaptation without relieving the subleaflet tethering forces. In this biomechanical study, we demonstrate that papillary muscle approximation (PMA) before UMA can...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | JTCVS Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666273621000899 |
| _version_ | 1818744630407069696 |
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| author | Samantha Zhan-Moodie, BS Dongyang Xu, MS Kirthana Sreerangathama Suresh, MS Qi He, BS Daisuke Onohara, MD, PhD Kanika Kalra, MD Robert A. Guyton, MD Eric L. Sarin, MD Muralidhar Padala, PhD |
| author_facet | Samantha Zhan-Moodie, BS Dongyang Xu, MS Kirthana Sreerangathama Suresh, MS Qi He, BS Daisuke Onohara, MD, PhD Kanika Kalra, MD Robert A. Guyton, MD Eric L. Sarin, MD Muralidhar Padala, PhD |
| author_sort | Samantha Zhan-Moodie, BS |
| collection | DOAJ |
| description | Background: Undersizing mitral annuloplasty (UMA) to repair functional mitral regurgitation (FMR) lacks durability, as it forces leaflet coaptation without relieving the subleaflet tethering forces. In this biomechanical study, we demonstrate that papillary muscle approximation (PMA) before UMA can drastically relieve tethering forces and improve valve function, without the need for significant annular downsizing. Methods: An ex vivo model of FMR was used, in which pig mitral valves were geometrically perturbed to induce FMR, and the repairs were performed. Nine pig mitral valves were studied in the following sequence: normal (baseline), FMR, true-sized annuloplasty to 30 mm (true-sized ring [TSR]), and undersized annuloplasty to 26 mm (down-sized ring [DSR]), along with concomitant PMA at both ring sizes. Mitral regurgitation, valve kinematics, and chordal forces were measured and compared among the groups. Results: FMR geometry induced a mean regurgitant fraction of 16.31 ± 7.33% compared with 0% at baseline. TSR reduced the regurgitant fraction to 6.05 ± 5.63%, whereas DSR reduced it to 5.06 ± 6.76%. The addition of PMA before the use of these rings reduced the mean regurgitant fraction to 3.87 ± 6.79% with the TSR (TSR + PMA) and 3.71 ± 6.25% with the DSR (DSR + PMA). Mean peak anterior and posterior marginal chordal forces were elevated to 0.09 ± 0.1 N and 0.12 ± 0.1 N, respectively, with FMR and were not reduced by annuloplasty of either sizes. The addition of PMA significantly reduced these forces to 0.23 ± 0.02 N and 0.51 ± 0.04 N. Conclusions: This biomechanical study demonstrates that PMA relieves tethering forces, and concomitantly with annuloplasty it mobilizes the leaflets to achieve physiological valve closure. Such a result could be achieved without the need for extensive annular downsizing. |
| first_indexed | 2024-12-18T02:47:22Z |
| format | Article |
| id | doaj.art-7cef017e879b4278aaf84f7556d20dfa |
| institution | Directory Open Access Journal |
| issn | 2666-2736 |
| language | English |
| last_indexed | 2024-12-18T02:47:22Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JTCVS Open |
| spelling | doaj.art-7cef017e879b4278aaf84f7556d20dfa2022-12-21T21:23:32ZengElsevierJTCVS Open2666-27362021-09-01791104Papillary muscle approximation reduces systolic tethering forces and improves mitral valve closure in the repair of functional mitral regurgitationCentral MessagePerspectiveSamantha Zhan-Moodie, BS0Dongyang Xu, MS1Kirthana Sreerangathama Suresh, MS2Qi He, BS3Daisuke Onohara, MD, PhD4Kanika Kalra, MD5Robert A. Guyton, MD6Eric L. Sarin, MD7Muralidhar Padala, PhD8Structural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center, Emory University Hospital Midtown, Atlanta, GaStructural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center, Emory University Hospital Midtown, Atlanta, GaStructural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center, Emory University Hospital Midtown, Atlanta, GaStructural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center, Emory University Hospital Midtown, Atlanta, GaStructural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center, Emory University Hospital Midtown, Atlanta, GaStructural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center, Emory University Hospital Midtown, Atlanta, GaStructural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center, Emory University Hospital Midtown, Atlanta, Ga; Division of Cardiothoracic Surgery, Department of Surgery, Emory University School of Medicine, Atlanta, GaStructural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center, Emory University Hospital Midtown, Atlanta, Ga; Department of Cardiac Surgery, INOVA Heart and Vascular Institute, Fairfax, VaStructural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center, Emory University Hospital Midtown, Atlanta, Ga; Division of Cardiothoracic Surgery, Department of Surgery, Emory University School of Medicine, Atlanta, Ga; Address for reprints: Muralidhar Padala, PhD, 380B Northyards Blvd, Atlanta, GA 30313.Background: Undersizing mitral annuloplasty (UMA) to repair functional mitral regurgitation (FMR) lacks durability, as it forces leaflet coaptation without relieving the subleaflet tethering forces. In this biomechanical study, we demonstrate that papillary muscle approximation (PMA) before UMA can drastically relieve tethering forces and improve valve function, without the need for significant annular downsizing. Methods: An ex vivo model of FMR was used, in which pig mitral valves were geometrically perturbed to induce FMR, and the repairs were performed. Nine pig mitral valves were studied in the following sequence: normal (baseline), FMR, true-sized annuloplasty to 30 mm (true-sized ring [TSR]), and undersized annuloplasty to 26 mm (down-sized ring [DSR]), along with concomitant PMA at both ring sizes. Mitral regurgitation, valve kinematics, and chordal forces were measured and compared among the groups. Results: FMR geometry induced a mean regurgitant fraction of 16.31 ± 7.33% compared with 0% at baseline. TSR reduced the regurgitant fraction to 6.05 ± 5.63%, whereas DSR reduced it to 5.06 ± 6.76%. The addition of PMA before the use of these rings reduced the mean regurgitant fraction to 3.87 ± 6.79% with the TSR (TSR + PMA) and 3.71 ± 6.25% with the DSR (DSR + PMA). Mean peak anterior and posterior marginal chordal forces were elevated to 0.09 ± 0.1 N and 0.12 ± 0.1 N, respectively, with FMR and were not reduced by annuloplasty of either sizes. The addition of PMA significantly reduced these forces to 0.23 ± 0.02 N and 0.51 ± 0.04 N. Conclusions: This biomechanical study demonstrates that PMA relieves tethering forces, and concomitantly with annuloplasty it mobilizes the leaflets to achieve physiological valve closure. Such a result could be achieved without the need for extensive annular downsizing.http://www.sciencedirect.com/science/article/pii/S2666273621000899mitral valve repairannuloplastysubannular repairinterpapillary muscle separationsecondary mitral regurgitationischemic mitral regurgitation |
| spellingShingle | Samantha Zhan-Moodie, BS Dongyang Xu, MS Kirthana Sreerangathama Suresh, MS Qi He, BS Daisuke Onohara, MD, PhD Kanika Kalra, MD Robert A. Guyton, MD Eric L. Sarin, MD Muralidhar Padala, PhD Papillary muscle approximation reduces systolic tethering forces and improves mitral valve closure in the repair of functional mitral regurgitationCentral MessagePerspective JTCVS Open mitral valve repair annuloplasty subannular repair interpapillary muscle separation secondary mitral regurgitation ischemic mitral regurgitation |
| title | Papillary muscle approximation reduces systolic tethering forces and improves mitral valve closure in the repair of functional mitral regurgitationCentral MessagePerspective |
| title_full | Papillary muscle approximation reduces systolic tethering forces and improves mitral valve closure in the repair of functional mitral regurgitationCentral MessagePerspective |
| title_fullStr | Papillary muscle approximation reduces systolic tethering forces and improves mitral valve closure in the repair of functional mitral regurgitationCentral MessagePerspective |
| title_full_unstemmed | Papillary muscle approximation reduces systolic tethering forces and improves mitral valve closure in the repair of functional mitral regurgitationCentral MessagePerspective |
| title_short | Papillary muscle approximation reduces systolic tethering forces and improves mitral valve closure in the repair of functional mitral regurgitationCentral MessagePerspective |
| title_sort | papillary muscle approximation reduces systolic tethering forces and improves mitral valve closure in the repair of functional mitral regurgitationcentral messageperspective |
| topic | mitral valve repair annuloplasty subannular repair interpapillary muscle separation secondary mitral regurgitation ischemic mitral regurgitation |
| url | http://www.sciencedirect.com/science/article/pii/S2666273621000899 |
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