Toxicity of Jatropha curcas L. latex in Allium cepa test
The latex obtained from Jatropha curcas (physic nut) is used in traditional medicine to treat a variety of disturbs, including burns, hemorrhoids, ringworm and ulcers. Phytochemical analyses have shown that J. curcas latex contains natural compounds with therapeutic potential. In this study, the tox...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Universidade Federal de Uberlândia
2017-09-01
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| Series: | Bioscience Journal |
| Subjects: | |
| Online Access: | https://seer-dev.ufu.br/index.php/biosciencejournal/article/view/33835 |
| _version_ | 1818156994677178368 |
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| author | Angelina Luzia Ciappina Fabrício Alves Ferreira Illana Reis Pereira Tiago Rodrigues Sousa Fábio Santos Matos Paulo Roberto Melo Reis Pablo José Gonçalves Elisa Flávia Luiz Cardoso Bailão Luciane Madureira Almeida |
| author_facet | Angelina Luzia Ciappina Fabrício Alves Ferreira Illana Reis Pereira Tiago Rodrigues Sousa Fábio Santos Matos Paulo Roberto Melo Reis Pablo José Gonçalves Elisa Flávia Luiz Cardoso Bailão Luciane Madureira Almeida |
| author_sort | Angelina Luzia Ciappina |
| collection | DOAJ |
| description | The latex obtained from Jatropha curcas (physic nut) is used in traditional medicine to treat a variety of disturbs, including burns, hemorrhoids, ringworm and ulcers. Phytochemical analyses have shown that J. curcas latex contains natural compounds with therapeutic potential. In this study, the toxicity, cytotoxicity and genotoxicity effects of J. curcas latex on the root cells of Allium cepa were examined. Onion seeds and bulbs were exposed to seven different concentrations of latex and then the roots were submitted to macro and microscopic analyses. Water and sodium azide were used as negative and positive controls, respectively. The analysis of root growth showed that J. curcas crude latex or 50% diluted is highly toxic. Cytogenetic results showed that the mitotic index of the onion roots submitted to latex treatment decreased significantly compared to the negative control, which suggests that the latex is cytotoxic. High incidence of chromosome aberrations in the cells treated with J. curcas latex was observed too, indicating that the latex also presents genotoxic effect. The analyses presented in this report suggest the toxic, cytotoxic and genotoxic effects of J. curcas latex. Then, the indiscriminate use of J. curcas latex in folk medicine could bring risk to human health.
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| first_indexed | 2024-12-11T15:07:08Z |
| format | Article |
| id | doaj.art-7cf217ee92964d1eb217e00b2753b24c |
| institution | Directory Open Access Journal |
| issn | 1981-3163 |
| language | English |
| last_indexed | 2024-12-11T15:07:08Z |
| publishDate | 2017-09-01 |
| publisher | Universidade Federal de Uberlândia |
| record_format | Article |
| series | Bioscience Journal |
| spelling | doaj.art-7cf217ee92964d1eb217e00b2753b24c2022-12-22T01:00:51ZengUniversidade Federal de UberlândiaBioscience Journal1981-31632017-09-01335Toxicity of Jatropha curcas L. latex in Allium cepa test Angelina Luzia Ciappina0Fabrício Alves Ferreira1Illana Reis Pereira2Tiago Rodrigues Sousa3Fábio Santos Matos4Paulo Roberto Melo Reis5Pablo José Gonçalves6Elisa Flávia Luiz Cardoso Bailão7Luciane Madureira Almeida8Universidade Estadual de GoiásUniversidade Estadual de GoiásUniversidade Estadual de GoiásUniversidade Estadual de GoiásUniversidade Estadual de GoiásPontifícia Universidade Católica de GoiásUniversidade Federal de GoiásUniversidade Estadual de GoiásUniversidade Estadual de GoiásThe latex obtained from Jatropha curcas (physic nut) is used in traditional medicine to treat a variety of disturbs, including burns, hemorrhoids, ringworm and ulcers. Phytochemical analyses have shown that J. curcas latex contains natural compounds with therapeutic potential. In this study, the toxicity, cytotoxicity and genotoxicity effects of J. curcas latex on the root cells of Allium cepa were examined. Onion seeds and bulbs were exposed to seven different concentrations of latex and then the roots were submitted to macro and microscopic analyses. Water and sodium azide were used as negative and positive controls, respectively. The analysis of root growth showed that J. curcas crude latex or 50% diluted is highly toxic. Cytogenetic results showed that the mitotic index of the onion roots submitted to latex treatment decreased significantly compared to the negative control, which suggests that the latex is cytotoxic. High incidence of chromosome aberrations in the cells treated with J. curcas latex was observed too, indicating that the latex also presents genotoxic effect. The analyses presented in this report suggest the toxic, cytotoxic and genotoxic effects of J. curcas latex. Then, the indiscriminate use of J. curcas latex in folk medicine could bring risk to human health. https://seer-dev.ufu.br/index.php/biosciencejournal/article/view/33835antiproliferative effectgenotoxicitymedicinal plants and physic nut. |
| spellingShingle | Angelina Luzia Ciappina Fabrício Alves Ferreira Illana Reis Pereira Tiago Rodrigues Sousa Fábio Santos Matos Paulo Roberto Melo Reis Pablo José Gonçalves Elisa Flávia Luiz Cardoso Bailão Luciane Madureira Almeida Toxicity of Jatropha curcas L. latex in Allium cepa test Bioscience Journal antiproliferative effect genotoxicity medicinal plants and physic nut. |
| title | Toxicity of Jatropha curcas L. latex in Allium cepa test |
| title_full | Toxicity of Jatropha curcas L. latex in Allium cepa test |
| title_fullStr | Toxicity of Jatropha curcas L. latex in Allium cepa test |
| title_full_unstemmed | Toxicity of Jatropha curcas L. latex in Allium cepa test |
| title_short | Toxicity of Jatropha curcas L. latex in Allium cepa test |
| title_sort | toxicity of jatropha curcas l latex in allium cepa test |
| topic | antiproliferative effect genotoxicity medicinal plants and physic nut. |
| url | https://seer-dev.ufu.br/index.php/biosciencejournal/article/view/33835 |
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