Integrated Chinese Herbal Medicine Therapy Improves the Survival of Patients With Ovarian Cancer
Background: Ovarian cancer is the seventh most commonly diagnosed malignancy worldwide and has the highest mortality rate among all gynecological cancers. Chinese herbal medicine (CHM) is widely applied in Taiwan and has been used in integrated therapies to treat patients with cancer. Methods: Patie...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-11-01
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| Series: | Integrative Cancer Therapies |
| Online Access: | https://doi.org/10.1177/1534735419881497 |
| _version_ | 1828526001673469952 |
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| author | Cherry Yin-Yi Chang MD, PhD Pei-Yuu Yang MD Fuu-Jen Tsai MD, PhD Te-Mao Li MD, PhD Jian-Shiun Chiou MS Chao-Jung Chen PhD Ting-Hsu Lin MS Chiu-Chu Liao MS Shao-Mei Huang MS Bo Ban MD, PhD Wen-Miin Liang PhD Ying-Ju Lin PhD |
| author_facet | Cherry Yin-Yi Chang MD, PhD Pei-Yuu Yang MD Fuu-Jen Tsai MD, PhD Te-Mao Li MD, PhD Jian-Shiun Chiou MS Chao-Jung Chen PhD Ting-Hsu Lin MS Chiu-Chu Liao MS Shao-Mei Huang MS Bo Ban MD, PhD Wen-Miin Liang PhD Ying-Ju Lin PhD |
| author_sort | Cherry Yin-Yi Chang MD, PhD |
| collection | DOAJ |
| description | Background: Ovarian cancer is the seventh most commonly diagnosed malignancy worldwide and has the highest mortality rate among all gynecological cancers. Chinese herbal medicine (CHM) is widely applied in Taiwan and has been used in integrated therapies to treat patients with cancer. Methods: Patients with ovarian cancer who were registered in the Taiwan Registry for Catastrophic Illness Patients Database between 1997 and 2012 were considered for this study. A 1:1 individual matching by age was implemented. A total of 101 CHM users and 101 non-CHM users were involved. A Cox proportional hazard regression model was applied to evaluate the hazard ratio of overall mortality. The Kaplan-Meier method and log-rank test were used to calculate the cumulative incidence of the overall survival rate. Association rule mining and network analysis were used to analyze CHM prescription patterns. Results: CHM users showed a significantly lower risk of overall mortality than nonusers (hazard ratio = 0.45, 95% confidence interval = 0.23-0.91; P = .0256; multivariate Cox proportional hazard model). The cumulative incidence of the overall survival probability was higher for CHM users than for non-CHM users (log-rank test, P = .0009). Association rule mining and network analysis suggested that the main CHM cluster was associated with the usage of Bu-Zhong-Yi-Qi-Tang, Chuan-Xiong, and Xi-Xin, followed by the use of Bai-Shao, Da-Huang, and Di-Huang. Conclusions: CHM, as an adjunctive therapy, may reduce the overall mortality in patients with ovarian cancer. A list of herbal medicines that could potentially be used in future studies and clinical trials has also been provided. |
| first_indexed | 2024-12-11T21:15:34Z |
| format | Article |
| id | doaj.art-7cf23443587349d182026fed077558c6 |
| institution | Directory Open Access Journal |
| issn | 1534-7354 1552-695X |
| language | English |
| last_indexed | 2024-12-11T21:15:34Z |
| publishDate | 2019-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Integrative Cancer Therapies |
| spelling | doaj.art-7cf23443587349d182026fed077558c62022-12-22T00:50:35ZengSAGE PublishingIntegrative Cancer Therapies1534-73541552-695X2019-11-011810.1177/1534735419881497Integrated Chinese Herbal Medicine Therapy Improves the Survival of Patients With Ovarian CancerCherry Yin-Yi Chang MD, PhD0Pei-Yuu Yang MD1Fuu-Jen Tsai MD, PhD2Te-Mao Li MD, PhD3Jian-Shiun Chiou MS4Chao-Jung Chen PhD5Ting-Hsu Lin MS6Chiu-Chu Liao MS7Shao-Mei Huang MS8Bo Ban MD, PhD9Wen-Miin Liang PhD10Ying-Ju Lin PhD11China Medical University Hospital, TaichungTaipei Medical University Hospital, TaipeiAsia University, TaichungChina Medical University, TaichungChina Medical University, TaichungChina Medical University, TaichungChina Medical University Hospital, TaichungChina Medical University Hospital, TaichungChina Medical University Hospital, TaichungChinese Research Center for Behavior Medicine in Growth and Development, Jining, Shandong, ChinaChina Medical University, TaichungChina Medical University, TaichungBackground: Ovarian cancer is the seventh most commonly diagnosed malignancy worldwide and has the highest mortality rate among all gynecological cancers. Chinese herbal medicine (CHM) is widely applied in Taiwan and has been used in integrated therapies to treat patients with cancer. Methods: Patients with ovarian cancer who were registered in the Taiwan Registry for Catastrophic Illness Patients Database between 1997 and 2012 were considered for this study. A 1:1 individual matching by age was implemented. A total of 101 CHM users and 101 non-CHM users were involved. A Cox proportional hazard regression model was applied to evaluate the hazard ratio of overall mortality. The Kaplan-Meier method and log-rank test were used to calculate the cumulative incidence of the overall survival rate. Association rule mining and network analysis were used to analyze CHM prescription patterns. Results: CHM users showed a significantly lower risk of overall mortality than nonusers (hazard ratio = 0.45, 95% confidence interval = 0.23-0.91; P = .0256; multivariate Cox proportional hazard model). The cumulative incidence of the overall survival probability was higher for CHM users than for non-CHM users (log-rank test, P = .0009). Association rule mining and network analysis suggested that the main CHM cluster was associated with the usage of Bu-Zhong-Yi-Qi-Tang, Chuan-Xiong, and Xi-Xin, followed by the use of Bai-Shao, Da-Huang, and Di-Huang. Conclusions: CHM, as an adjunctive therapy, may reduce the overall mortality in patients with ovarian cancer. A list of herbal medicines that could potentially be used in future studies and clinical trials has also been provided.https://doi.org/10.1177/1534735419881497 |
| spellingShingle | Cherry Yin-Yi Chang MD, PhD Pei-Yuu Yang MD Fuu-Jen Tsai MD, PhD Te-Mao Li MD, PhD Jian-Shiun Chiou MS Chao-Jung Chen PhD Ting-Hsu Lin MS Chiu-Chu Liao MS Shao-Mei Huang MS Bo Ban MD, PhD Wen-Miin Liang PhD Ying-Ju Lin PhD Integrated Chinese Herbal Medicine Therapy Improves the Survival of Patients With Ovarian Cancer Integrative Cancer Therapies |
| title | Integrated Chinese Herbal Medicine Therapy Improves the Survival of Patients With Ovarian Cancer |
| title_full | Integrated Chinese Herbal Medicine Therapy Improves the Survival of Patients With Ovarian Cancer |
| title_fullStr | Integrated Chinese Herbal Medicine Therapy Improves the Survival of Patients With Ovarian Cancer |
| title_full_unstemmed | Integrated Chinese Herbal Medicine Therapy Improves the Survival of Patients With Ovarian Cancer |
| title_short | Integrated Chinese Herbal Medicine Therapy Improves the Survival of Patients With Ovarian Cancer |
| title_sort | integrated chinese herbal medicine therapy improves the survival of patients with ovarian cancer |
| url | https://doi.org/10.1177/1534735419881497 |
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